Antifertility effects of an LHRH agonist in male mice

Contraception

Volumn 53, Issue 5, 1996, Pages 299-306

  Kher, Rajesh ^a,c   Kalla, Natwar R ^b  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

^b PANJAB UNIVERSITY   (India)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

antifertility; buserelin; LHRH agonist; spermatogenesis; testes

Indexed keywords

BUSERELIN ACETATE;

ANIMAL EXPERIMENT; ARTICLE; AZOOSPERMIA; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; GROWTH INHIBITION; MALE; MALE STERILIZATION; NONHUMAN; RAT; SPERMATOZOON MATURATION; SPERMATOZOON MOTILITY; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029875524     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/0010-7824(96)00064-9     Document Type: Article

References (33)

1. 10]LHRH ethylamide. Endocrinol 1978;103:641-3.
2. Bhasin S, Swerdloff RS. Mechanisms of gonadotropin-releasing hormone agonist action in the human male. Endocr Rev 1986;7:106-14.
3. Vickery, BH. Comparison of the potential therapeutic utilities with gonadotropin-releasing hormone agonists and antagonists. Endocr Rev 1986;7:115-24.
4. Heber D, Swerdloff RS. Male contraception: synergism of gonadotropin-releasing hormone analog and testosterone in suppressing gonadotropin. Science 1980;209: 936-8.
5. Catt KJ, Harwood JP, Aquilera G, Dufau ML. Hormonal regulation of peptide receptors and target cell responses. Nature 1979;280:109-16.
6. Sandow J. Gonadotropic and antigonadotropic action of LHRH analogs. In: Muller EE, Macleod RM, eds. Neuroendocrine Perspectives; Vol 1. Amsterdam:Elsevier Biomedical Press, 1982:339-95.
7. Belchetz PE, Plant TM, Nakai Y, Koegh EJ, Knobil E. Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone. Science 1978;202:631-3.
8. Belanger A, Cusan L, Auclair C, Seguin C, Caron S, Labrie F. Effect of an LHRH agonist and hCG on testicular steroidogenesis in the adult rat. Biol Reprod 1980;22:1094-101.
9. Corbin A, Fredrick J, Jones B, et al. Comparison of LHRH agonists and antagonists. In: Labrie F, Belanger A, Dupont A, eds. LHRH and its analogs. New York:Elsevier Science Publishers, 1984:95-122.
10. Clayton RN, Katikineni M, Chan V, Dufau ML, Catt KJ. Direct inhibition of testicular function by LHRH. Mediation by specific gonadotropin-releasing hormone receptors in interstitial cells. Proc Natl Acad Sci USA 1980;77:4459-63.
11. Labrie F, Belanger A, Cusan L, et al. Antifertility effects of LHRH agonists in the male. J Androl 1980;1:209-28.
12. Bex FJ, Corbin A, France E. Resistance of the mouse to the antifertility effects of LHRH agonists. Life Sci 1982; 30:1263-9.
13. Wang NG, Sundaram K, Pavlou S, Rivier J, Vale W, Bardin CW. Mice are insensitive to the antitesticular effects of luetinizing hormone-releasing hormone agonists. Endocrinol 1983;112:331-5.
14. World Health Organisation. WHO laboratory manual for the examination of human semen and semencervical mucus interaction. Cambridge:Cambridge University Press, 1987:6.
15. Leblond LP, Clermont Y. Definition of the stages of the cycle of seminiferous epithelium in the rat. Ann NY Acad Sci 1952;55:548-73.
16. Vassualt A. Lactate dehydrogenase: UV-method with pyruvate and NADH. In: Bergmeyer J, Grabl M, eds. Methods of enzymatic analysis; Vol III. Florida:VCH Press, 1987:118-26.
17. Schatz L, Segal HL. Reduction of α-ketoglutarate by homogenate LDH-X of testicular tissue. J Biol Chem 1969; 244:4393-7.
18. Seligman AM. Histochemical methods for dehydrogenases: I. Diphosphopyridine nucleotide diaphorase; II. Steroid 3B-ol dehydrogenase. In: Colowick SP, Kaplan NO, eds. Methods in enzymology; Vol VI. New York:Academic Press, 1963:892-3.
19. Sandow J, Rechenberg Wv, Baeder C, Engelbart K. Antifertility effects of an LHRH analog in male rats and dogs. Int J Fertil 1980;25:213-21.
20. Dube D, Assaf A, Pelletier G, Labrie F. Morphological study of the effects of a GnRH agonist on the canine testis after four months of treatment and recovery. Acta Endocrinol (Copenh) 1987;116:413-7.
21. Akhtar FB, Wickings EJ, Zaidi P, Nieschlag E. Pituitary and testicular functions in sexually mature rhesus monkeys under high dose LHRH-agonist treatment. Acta Endocrinol (Copenh) 1982;101:113-8.
22. Rabin D, Linde R, Doelle G, Alexander N. Experience with a potent LHRH agonist in normal men: an approach to the development of a male contraceptive. In: Zatuchni GI, Sheltan JD, Sciarra JJ, eds. LHRH peptides as male and female contraceptives. Philadelphia:Harper and Row, 1981:296-306.
23. Labrie F, Auclair C, Cusan L, Kelly PA, Pelletier G, Ferland L. Inhibitory effects of LHRH and its agonists on testicular gonadotropin receptors and spermatogenesis in the rat. Int J Androl, Suppl 1978;2:303-8.
24. Bergquist C, Nillius SJ, Bergh T, Skarin G, Wide L. Inhibitory effects on gonadotropin secretion and gonadal functions in men during treatment with a potent stimulatory luteinizing hormone-releasing hormone analog. Acta Endocrinol (Copenh) 1979;91:601-8.
25. Gonzalvo V, Calvo MA, Navalon P, et al. Anatomopathologic changes in the testis following prolonged treatment with LHRH agonists: Experimental study in rats. Actas Urologicas Espanolas 1994;18:159-62.
26. Limn SF, Cowen GM, Morris KD, Fraser HM. Influence of the gonad on the degree of suppression induced by an LHRH agonist implant in the marmoset monkey. J Endocrinol 1992;132:217-24.
27. Patanelli DJ, Nelson WO. A quantitative study of inhibition and recovery of spermatogenesis. Recent Prog Horm Res 1964;20:491-543.
28. Labrie F, Belanger A, Seguin C, et al. Inhibition of testicular and ovarian functions by LHRH agonists. In: Jagiello G, Vogel HJ, eds. Bioregulators of Reproduction. New York:Academic Press, 1981:305-41.
29. Schally AV, Coy DH. Stimulatory and inhibitory analogs of LH-releasing hormone: Basic and clinical studies. In: McCann SM, Dhindsa DS, eds. Role of Peptides and Proteins in Control of Reproduction. New York:Elsevier Science Inc., 1983:89-110.
30. 2 (10)]-LHRH ethyamide, has no direct effect on spermatogenesis in the rat. Biol Reprod 1988;38:1165-70.
31. Blanco A, Burgos C, Gerez de Burgos NM, Montamat EE. Properties of the lactate dehydrogenase isoenzyme. Biochem J 1976;153:165-72.
32. Bokser L, Zalatnai A, Schally AV. Inhibition of pituitary-gonadal axis in mice by long-term administration of D-Trp-6-LHRH microcapsules. J Reprod Feril 1989; 85:569-74.
33. Redding TW, Schally AV. Inhibition of the pituitary-gonadal axis in nude male mice by continuous administration of LHRH agonists and antagonists. J Endocrinol 1990;126:309-15.