Ciliary body

Microscopy Research and Technique

Volumn 33, Issue 5, 1996, Pages 390-439

  Tamm, Ernst R ^a,b   Lütjen Drecoll, Elke ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b NATIONAL EYE INSTITUTE   (United States)

Author keywords

Ciliary epithelium; Ciliary muscle; Electron microscopy; Human eye

Indexed keywords

CELL ULTRASTRUCTURE; CILIARY BODY; CILIARY MUSCLE; ELECTRON MICROSCOPY; MECHANORECEPTOR; MUSCLE INNERVATION; MYOFILAMENT; PRESBYOPIA; PRIORITY JOURNAL; REVIEW;

CELL COMMUNICATION; CILIARY BODY; HUMANS; MECHANORECEPTORS;

EID: 0029875473     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0029(19960401)33:5<390::AID-JEMT2>3.0.CO;2-S     Document Type: Review

References (200)

1. Armaly, M.F. (1968) Degeneration of ciliary muscle and iris sphincter muscle following resection of the ciliary ganglion. Trans. Am. Ophthalmol. Soc., 66:476-502.
2. Armaly, M.F., and Burian, H.M. (1958) Changes in the tonogram during accommodation. Arch. Ophthalmol., 60:60-69.
3. Ashton, F.T., Somlyo, A.V., and Somlyo, A.P. (1975) The contractile apparatus of vascular smooth muscle: Intermediate high voltage stereo electron microscopy. J. Mol. Biol., 98:17-29.
4. Bairati, A.J., and Orzalesi, N. (1966) The ultrastructure of the epithelium of the ciliary body. A study of the junctional complexes and of the changes associated with the production of plasmoid aqueous humor. Z. Zellforsch., 69:635-658.
5. Balazs, E.A., Toth, L.Z.J., and Mitchell, A.P. (1964) Studies on the structure of the vitreous body. XII. Cytological and histochemical studies on the connective tissue layer. Exp. Eye Res., 3:57-71.
6. Barsotti, M.F., Bartels, S.P., Freddo, T.F., and Kamm, R.D. (1992) The source of protein in the aqueous humor of the normal monkey eye. Invest. Opthalmol. Vis. Sci., 33:581-595.
7. Bárány, E.H. (1966) The mode of action of miotics on outflow resistance: A study of pilocarpine in the vervet monkey, Cercopithecus ethiops. Trans. Ophthalmol. Soc. U.K., 86:539-578.
8. Bárány, E.H. (1967) The immediate effect on outflow resistance of intravenous pilocarpine in the vervet monkey, Cercopithecus ethiops. Invest. Opthalmol. Vis. Sci., 6:378-380.
9. Bárány, E.H., and Rohen, J.W. (1965) Localized contraction and relaxation within the ciliary muscle of the vervet (Cercopithecus ethiops). In: The Structure of the Eye. Vol. II. Symp. J.W. Rohen, ed. Schattauer, Stuttgart, pp. 287-311.
10. Bárány, E.H., Berrie, C.P., Birdsall, N.J.M., Burgen, A.S.V., and Hulme, E.C. (1982) The binding properties of the muscarinic receptors of the cynomolgus monkey ciliary body and the response to the induction of agonist subsensitivity. Brit. J. Pharmacol., 77:731-739.
11. Bill, A. (1968a) Capillary permeability to and extravaseular dynamics of myoglobin, albumin and gammaglobulin in the uvea. Acta Physiol. Scand., 73:204.
12. Bill, A. (1968b) A method to determine osmotically effective albumin and gamma-globulin concentrations in tissue fluids, its application to the uvea, and a note on the effects of capillary "leaks" on tissue fluid dynamics. Acta Physiol. Scand., 73:511-522.
13. Birmingham, A.R. (1970) Sympathetic denervation of the smooth muscle of the vas deferens. J. Physiol., 206:645-661.
14. Bito L.Z., and Miranda O.G. (1987) Presbyopia: Comparative and evolutionary perspectives, Atti della Fondazione Giorgio Ronchi, Anno XLII, N. 1-2, Firenze.
15. Bito, L.Z., and Miranda, O.C. (1989) Accommodation and presbyopia. In: Ophthalmology Annual. R.D. Reinecke, ed. Raven Press, New York, pp. 103-127.
16. Bito, L.Z., DeRousseau, C.J., Kaufman, P.L., and Bito, J.W. (1982) Age-dependent loss of accommodative amplitude in rhesus monkeys: An animal model for presbyopia. Invest. Opthalmol. Vis. Sci., 23:23-31.
17. Bloom, G.D., and Balazs, E.A. (1965) An electron microscopic study of hyalocytes. Exp. Eye Res., 4:249-255.
18. Bozler, E. (1948) Conduction, automaticity and tonus of viszeral muscle. Experientia, 4:213-218.
19. Bock, P., and Gorgas, K. (1976) Fine structure of baroreceptor terminals in the carotid sinus of guinea pigs and mice. Cell Tissue Res., 170:95-112.
20. Brubaker, R.F. (1991) Flow of aqueous humor in humans (The Friedenwald Lecture). Invest. Opthalmol. Vis. Sci., 32:3145-3166.
21. Brücke, E. (1846) Über den Muskel Cramptonianus und den Spann-muskel der Choroidea. Archiv für Anatomie, Physiologie und wissenschaftliche Medizin, 370-377.
22. Calasans, O.M. (1953) Arquitettura do músculo ciliar no homen. Ann. Fac. Med. Sao Paulo, 27:3-98.
23. Campbell, G.R., Gibbins, I., Allan, I., and Gannon, B. (1977) Effects of long term denervation on smooth muscle of the chicken expansor secundarium. Cell Tissue Res., 176:143-156.
24. Carpenter S., and Karpati G. (1984) Pathology of Skeletal Muscle. Churchill Livingstone, New York.
25. Chamley-Campbell, J., Campbell, G.R., and Ross, R. (1979) The smooth muscle cell in culture. Physiol. Rev., 59:1-61.
26. Cole, D.F. (1964) Localization of ouabain-sensitive adenosine triphosphatase in ciliary epithelium. Exp. Eye Res., 3:72-75.
27. Duke-Elder S. (1958) System of Ophthalmology. Vol. I. The Eye in Evolution. C.V. Mosby, St. Louis.
28. Ehinger, B. (1966) Adrenergic nerves to the eye and to related structures in man and in the cynomolgus monkey (Macaca irus). Invest. Opthalmol. Vis. Sci., 5:42-52.
29. Ehinger, B. (1971) A comparative study of the adrenergic nerves to the anterior eye segment of some primates. Z. Zellforsch., 116:157-177.
30. Ehinger, B., and Falck, B. (1970) Innervation of iridic melanophores. Z. Zellforsch., 105:538-542.
31. Eichhorn, M., and Lütjen-Drecoll, E. (1993) Distribution of endothelin-like immunoreactivity in the human ciliary epithelium. Curr. Eye Res., 12:753-757.
32. Enoch, I.M. (1976) Retinal stretch and accommodation. In: Current Concepts in Ophthalmology, Vol. 5. H.E. Kaufman and T.J. Zimmerman, eds. C.V. Mosby Co., St. Louis, pp. 59-78.
33. Erickson-Lamy, K.A., Polansky, J.R., Kaufman, P.L., and Zlock, D.M. (1987) Cholinergic drugs alter ciliary muscle response and receptor content. Invest. Opthalmol. Vis. Sci., 28:375-383.
34. Fincham, E.F. (1037) The mechanism of accommodation. Brit. J. Ophthalmol., Mon. Suppl. No. 8:7-80.
35. Fine, S.B., and Zimmerman, L.E. (1963) Light and electron microscopic observations on the ciliary epithelium in man and rhesus monkey. With particular reference to the base of the vitreous body. Invest. Opthalmol. Vis. Sci., 2:105-137.
36. Fisher, R.F. (1973) Presbyopia and its changes with age in the human crystalline lens. J. Physiol., 201:765-779.
37. Flocks, M., and Zweng, C. (1957) Studies on the mode of action of pilocarpine on aqueous outflow. Am. J. Ophthalmol., 44:380-387.
38. +-ATPase in the ciliary epithelium of the rabbit. Histochemistry, 88:613-621.
39. Flugel, C., Bárány, E.H., and Lütjen-Drecoll, E. (1990) Histochemical differences within the ciliary muscle and its function in accommodation. Exp. Eye Res., 50:219-226.
40. Flugel, C , Kinne, R.W., Streilein, J.W., and Lütjen-Drecoll, E. (1992) Distinctive distribution of HLA class II presenting and bone marrow derived cells in the anterior segment of human eyes. Curr. Eye Res., 11:1173-1183.
41. Franz, V. (1934) Vergleichende Anatomie des Wirbeltierauges. In: Handbuch der Vergleichenden Anatomie der Wirbeltiere. Vol. II/2. L. Bolk, E. Göppert, E. Kallius, W. Lubosch, eds. Urban & Schwarzenberg, Berlin, pp. 1-1202.
42. Freddo, T.F. (1988) Mitochondria attached to desmosomes in the ciliary epithelia of human, monkey and rabbit eyes. Cell Tissue Res., 251:671.
43. Freddo, T.F., Bartels, S.P., Barsotti, M.F., and Kamm, R.D. (1990) The source of proteins in the aqueous humor of the normal rabbit. Invest. Ophthalmol. Vis. Sci., 31:125-137.
44. Freeman, M.I., Jaeobson, B., and Balazs, E.A. (1979) The chemical composition of vitreous hyalocyte granules. Exp. Eye Res., 29:479-484.
45. Fry, G.N., Devine, C.E., and Burnstock, G. (1977) Freeze fracture studies on nexuses between smooth muscle cells. Close relationship to sarcoplasmic reticulum. J. Cell Biol., 72:26-34.
46. Fujita, H., Kondo, K., and Sears, M. (1984) Eine neue Funktion des nicht-pigmentierten Epithels der Ziliarkörperfortsätze bei der Kammerwasserproduktion. Klin. Mbl. Augenheilk., 185:29-34.
47. Funk, R. (1991) Ultrastructure of the ciliary process vasculature in cynomolgus monkeys. Exp. Eye Res., 53:461-469.
48. Funk, R., and Rohen, J.W. (1988) SEM studies of the functional morphology of the ciliary process vasculature in the cynomolgus monkey: Reactions after application of epinephrine. Exp. Eye Res., 47: 653-663.
49. Funk, R., and Rohen, J.W. (1990a) Scanning electron microscopic study on the vasculature of the human anterior eye segment, especially with respect to the ciliary processes. Exp. Eye Res., 51:651-661.
50. Funk, R., and Rohen, J.W. (1990b) Functional morphology of the vasculature in the anterior eye segment. In: Basic Aspects of Glaucoma Research II. E. Lütjen-Drecoll, and J.W. Rohen, eds. Schattauer, Stuttgart, New York, pp. 7-171.
51. Gabella, G. (1971) Caveolae intracellulares and sarcoplasmic reticulum in smooth muscle. J. Cell. Sci., 8:601-609.
52. Gabella, G. (1974) The sphincter pupillae of the guinea-pig: Structure of muscle cells, intercellular relations and density of innervation. Proc. R. Soc. Lond. B., 186:369-386.
53. Gabella, G. (1977) Arrangement of smooth muscle cells and intramuscular septa in the taenia coli. Cell Tissue Res., 184:195-212.
54. Gabella, G. (1979) Smooth muscle cell junctions and structural aspects of contraction. Br. Med. Bull., 35:213-218.
55. Gabella, G. (1981) Structure of smooth muscle. In: Smooth muscle: An Assessment of Current Knowledge. E. Bulbring, A.F. Brading, A.W. Jones, and T. Tomita, eds. Edward Arnold, London, pp. 1-46.
56. Gabella, G. (1984) Structural apparatus for force transmission in smooth muscles. Physiol. Rev., 64:455-474.
57. Gabella, G. (1987) Structure of muscles and nerves in the gastrointestinal tract. In: Physiology of the Gastrointestinal Tract. L.R. Johnson, ed. Raven Press, New York, pp. 335-381.
58. Gärtner, J. (1970) Electron microscopic observations on the cilio-zonular border area of the human eye with particular reference to the aging changes. Z. Anat. Entwickl.-Gesch., 131:263-273.
59. Gärtner, J. (1971) Aging changes of the ciliary epithelium border layers and their significance for intraocular pressure. Am. J. Ophthalmol., 72:1079-1093.
60. Geiger, B., Dutton, A.H., Tokuyasu, K.T., and Singer, S.J. (1981) Immunoelectron microscope studies of membrane-microfilament interactions: Distributions of α-actinin, tropomyosin, and vinculin in intestinal epithelial brush border and chicken gizzard smooth muscle cells. J. Cell Biol., 91:614-628.
61. Gimbrone, M.A., Cotran, R.S. (1975) Human vascular smooth muscle in culture. Growth and ultrastructure. Lab. Invest., 33:16-27.
62. Goag, H., Trinkaus-Randall, V., and Freddo, T.F. (1989) Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork. Curr. Eye Res., 8:1071-1082.
63. Gordon-Weeks, P.R. (1988) The ultrastructure of noradrenergic and cholinergic neurons in the autonomic nervous system. In: Handbook of Chemical Neuroanatomy. Vol. 6: The Peripheral Nervous System. A. Björklund, T. Hökfelt, and C. Owman, eds. Elsevier Science Publishers E.V., Amsterdam, pp. 117-142.
64. Greenlee, T.K., Ross, R., and Hartman, J.L. (1966) The fine structure of elastic fibers. J. Cell Biol., 30:59-70.
65. Grierson, I., Lee, W.R., and Abraham, S. (1978) Effects of pilocarpine on the morphology of the human outflow apparatus. Brit. J. Ophthalmol., 62:3302-313.
66. Hara, K., Lutjen-Drecoll, E., Prestele, H., and Rohen, J.W. (1977) Structural differences between regions of the ciliary body in primates. Invest. Opthalmol. Vis. Sci., 16:912-924.
67. Heimarm, K., and Kyrieleis, E. (1970) Netzhautablösung bei miotischer Therapie. Klin. Mbl. Augenheilk., 156:98.
68. Helbig, H., Kittredge, K.L., Coca-Prados, M., Davis, J., Palestine, A.G., and Nussenblatt, R.B. (1991) Mammalian ciliary-body epithelial cells in culture produce transforming growth factor-beta. Graefe's Arch. Clin. Exp. Ophthalmol., 229:84-87.
69. Helmholtz, H. (1856) Handbuch der physiologischen Optik. In: Allgemeine Enzyklopedie der Physik. Vol. IX. G. Rarsten, ed. Voss L , Leipzig,
70. Heumann, H.-G. (1976) The subcellular localization of calcium in vertebrate smooth muscle: Calcium-containing and calcium-accumulating structures in muscle cells of mouse intestine. Cell Tissue Res., 169:221-231.
71. Hollins, M. (1974) Does the central retina stretch during accommodation? Nature, 251:729.
72. Holthofer, H., Siegel, G.J., Tarkkanen, A., and Tervo, T. (1991) Immunocytochemical localization of carbonic anhydrase, NaK-ATPase and the bicarbonate chloride exchanger in the anterior segment of the human eye. Acta Ophthalmol., 69:149-154.
73. Ishikawa, T. (1962) Fine structure of the human ciliary muscle. Invest. Opthalmol. Vis. Sci., 1:587-608.
74. Iwanoff, A. (1869) Beiträge zur Anatomie des Ziliarmuskels. Albrecht v. Graefes Arch. Ophthalmol., 15:284-298.
75. Iwanoff, A. (1874) Der Uvealtractus. In: Handbuch der Gesamten Augenheilkunde. A. Graefe and T. Saemisch, eds. Verlag von Wilhelm Engelmann, Leipzig, pp. 265-287.
76. Kaufman, P.L., and Barany, E.H. (1976) Loss of acute pilocarpine effect on outflow facility following surgical disinsertion and retrodisplacement of the ciliary muscle from the scierai spur in the cynomolgus monkey. Invest. Opthalmol. Vis. Sci., 15:793-807.
77. Kivela, T, Fuchs, U., and Tarkkanen, A. (1992) Cytoskeleton in neuroectodermally denved epithelial and muscle cells of the human iris and ciliary body. J. Histochem. Cytochem., 40:1517-1526.
78. Kokott, W. (1948) Über die funktionelle Struktur der Aderhaut. Albrecht v. Graefes Arch. Ophthalmol., 148:706-734.
79. Koretz, J.F., Handelman, G.H., and Brown, N.P. (1984) Analysis of human crystalline lens curvature as a function of accommodative state and age. Vision Res., 24:1141-1151.
80. Korte, G.E., and D'Aversa, G. (1989) The elastic tissue of Bruch's membrane. Connections to the choroidal elastic tissue and the ciliary epithelium of the rabbit and human eyes. Arch. Ophthalmol., 107:1654-1658.
81. Kozart, D.M. (1968) Light and electron microscopic study of regional morphologic differences in the processes of the ciliary body in the rabbit. Invest. Opthalmol. Vis. Sci., 7:15-33.
82. Krauhs, J.M. (1979) Structure of rat aortic baroreceptors and their relationship to connective tissue. J. Neurocytol., 8:401-404.
83. Kupfer, C. (1962) Relationship of ciliary body meridional muscle and corneoscleral trabecular meshwork. Arch. Ophthalmol., 68:132-136.
84. Laties, A.M., and Jacobowitz, D. (1966) A comparative study of the autonomic innervation of the eye in monkey, cat and rabbit. Anat. Rec., 156:383-396.
85. Lauber, H. (1936) Der Strahlenkörper (Corpus ciliare). In: Handbuch der Mikroskopischen Anatomie des Menschen. W. von Möllendorf, ed. Verlag von Julius Springer, Berlin, pp. 134-182.
86. Leopold, I.H., and McDonald, RR. (1948) Di-isopropyl fluorophosphate (D.F.P.) in chronic glaucoma. Arch. Ophthalmol., 40:176.
87. Lepple-Wienhues, A., Becker, M., Stahl, F., Berweck, S., Hensen, J., Noske, W., Eichhorn, M., and Wiederholt, M. (1992) Endothelinlike immunoreactivity in the aqueous humor and in conditioned medium from cultured ciliary epithelial cells. Curr. Eye Res., 11: 1041-1046.
88. Lograno, M.D., and Daniele, E. (1988) Substance P as a transmitter in the human ciliary muscle. Pharm. Res. Comm., 20:901-905.
89. Lütjen, E. (1966) Histometrische Untersuchungen über den Ciliarmuskel der Primaten. Albrecht v. Graefes Arch. klin. exp. Ophthalmol., 171:121-133.
90. Lütjen-Drecoll, E. (1982) Functional morphology of the ciliary epithelium. In: Basic Aspects of Glaucoma Research. E. Lütjen-Drecoll, ed. F.K. Schattauer Verag, Stuttgart, New York, pp. 69-87.
91. Lütjen-Drecoll, E., Tamm, E. (1988) Morphological study of the anterior segment of cynomolgus monkey eyes following treatment with prostaglandin F2α. Exp. Eye Res., 47:761-769.
92. Lütjen-Drecoll, E., Tamm, E. (1989) Morphological basis for the reduction in intraocular pressure after topical treatment with prostaglandin F2α. In: The Ocular Effects of Prostaglandins and Other Eicosanoids. Proceedings in Clinical and Biological Research, Vol. 312. L. Bito and J. Stjernschantz, eds. Alan R. Liss, Inc., New York, pp. 437-446.
93. Lütjen-Drecoll, E., Dietl, T., Futa, R., and Rohen, J.W. (1982) Age changes of the trabecular meshwork. In: The Structure of the Eye. IV. Symposium. J.G. Hollyfield, ed. Elsevier North Holland Inc., Amsterdam, pp. 341-348.
94. Lütjen-Drecoll, E., Lonnerholm, G., and Eichhorn, M. (1983) Carbonic anhydrase distribution in the human and monkey eye by light and electron microscopy. Graefe's Arch. Clin. Exp. Ophthalmol., 220: 285-291.
95. Lütjen-Drecoll, E., Tamm, E., and Kaufman, P.L. (1988a) Age changes in rhesus monkey ciliary muscle: Light and electron microscopy. Exp. Eye Res., 47:885-899.
96. Lutjen-Drecoll, E., Tamm, E., and Kaufman, P.L. (1988b) Age-related loss of morphologic response to pilocarpine in rhesus monkey ciliary muscle. Arch. Ophthalmol., 106:1591-1598.
97. Lütjen-Drecoll, E., Rittig, M., Rauterberg, J., Jander, R., and Mollenhauer, J. (1989) Immunomicroscopical study of type VI collagen in the trabecular meshwork of normal and glaucomatous eyes. Exp. Eye Res., 48:139-147.
98. Lütjen-Drecoll, E., Rohen, J.W. (1992) Functional morphology of the trabecular meshwork. In: Duane's Foundations of Clinical Ophthalmology. W. Tasman and E.A. Jaeger, eds. J.B. Lippincott Company, Philadelphia, pp. 1-33.
99. Maeda, T., Sato, O., Kobayashi, S., Iwanaga, T., and Fujita, T. (1989) The ultrasiructure of ruffini endings in the periodontal ligament of rat incisors with special reference to the terminal Schwann cells (K-cells). Anat. Rec., 223:95-103.
100. Marr, W.C. (1947) The clinical use of di-isopropyl fluorophosphate (D.F.P.) in chronic glaucoma. Am. J. Ophthalmol., 30:1473.
101. Marshall, G.E., Konstas, A.G.P., Abraham, S., and Lee, W.R. (1992) Extracellular matrix in aged human ciliary body: An immunoelectron microscope study. Invest. Opthalmol. Vis. Sci., 33:2546-2559.
102. Matsusaka, T. (1982) Cytoarchitecture of choroidal melanocytes. Exp. Eye Res., 35:461-469.
103. Maurer, J. (1984) Histometrische Untersuchungen über Lageveräaderungen der Ora serrata bei verschiedenen Kontraktionszuständen des Ziliarmuskels im Primatenauge. Inaugural-Dissertation der Medizinischen Fakultät, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen.
104. Meesmann, A. (1952) Experimentelle Untersuchungen über die antagonistische Innervation der Ciliarmuskulatur. Albrecht v. Graefes Arch. Ophthalmol., 152:335-356.
105. Miledi, R., and Slater, C.R. (1969) Electron-microscopic structure of denervated skeletal muscle. Proc. Roy. Soc. London Ser. B, 174: 253-269.
106. Mishima, H., Bausher, L., Sears, M., Gochu, M., Ono, H., and Gregory, D. (1982) Fine structural studies of ciliary processes after treatment with cholera toxin or its B subunit. Graefe's Arch. Clin. Exp. Ophthalmol., 219:272-278.
107. Mollier, G. (1938) Der Bau des menschlichen Ciliarmuskels. Verh. Anat. Ges., 45:240-251.
108. Morrison, J.C., and Van Buskirk, E.M. (1984) Ciliary process microvasculature of the primate eye. Am. J. Ophthalmol., 97:372-384.
109. Moses, R.A. (1987) Accommodation. In: Adler's Physiology of the Eye. Clinical Application. R.A. Moses and W.M.J. Hart, eds. C.V. Mosby Co., St. Louis, pp. 291-310.
110. Mukuno, K., and Wittmer, R. (1977) Innervation of melanocytes in human iris. Albrecht v. Graefes Arch. Klin. Exp. Ophthalmol., 203: 1-8.
111. Müller, H. (1858) Uber einen ringförmigen Muskel am Ciliarmuskel des Menschen und über den Mechanismus der Akkommodation. Albrecht v. Graefes Arch. Ophthalmol, 3:1-24.
112. Neider, M.W., Crawford, K., Kaufman, P.L., and Bito, L.Z. (1990) In vivo videography of the rhesus monkey accommodative apparatus. Arch. Ophthalmol, 108:69-74.
113. Ober, M., and Rohen, J.W. (1979) Regional differences in the fine structure of the ciliary epithelium related to accommodation. Invest, Opthalmol. Vis. Sci., 18:655-664.
114. Okisaka, S. (1976a) Effects of paracentesis on the blood-aqueous barrier: A light and electron microscopic study on cynomolgus monkey. Invest. Opthalmol. Vis. Sci., 10:824-834.
115. Okisaka, S. (1976b) The effects of prostaglandin E1 on the ciliary epithelium and the drainage angle of cynomolgus monkeys: A light-and electron-microscopic study. Exp. Eye Res., 22:141-154.
116. Pellegrino, C., and Franzini, C. (1963) An electron microscope study of denervation atrophy in red and white skeletal muscle fibers. J. Cell Biol, 17:327-349.
117. Perez, G.M., and Keyser, R.B. (1986) Cell body counts in human ciliary ganglia. Invest. Opthalmol. Vis. Sci., 27:1428-1431.
118. Poyer, J.F., Kaufman, P.L., and Flügel, C. (1993) Age does not affect contractile responses of the isolated rhesus monkey ciliary muscle to muscarinic agonists. Curr. Eye Res., 12:413-422.
119. Prince J.H., Diesem C.D., Eglitis I, and Ruskell G.L. (1960) Anatomy and Physiology of the Eye and Orbit in Domestic Animals. Charles C. Thomas, Springfield, IL.
120. Raviola, G. (1971) The fine structure of the ciliary zonule and ciliary epithelium. Invest. Opthalmol. Vis. Sci., 10:851-869.
121. Raviola, G. (1974) Effects of paracentesis on the blood-aqueous barrier: An electron microscopic study on Macaca, mulatta using horseradish peroxidase as a tracer. Invest. Opthalmol. Vis. Sci., 13:828-858.
122. Raviola, G. (1977) The structural basis of the blood-ocular barriers. Exp. Eye Res., Suppl.:27-63.
123. Raviola, G. (1986) Evidence for a secretory process, distinct from that of the aqueous humor, in the ciliary epithelium of macaca mulatta. Trans. Ophthalmol. Soc. U.K., 105:140-148.
124. Raviola, G., Raviola, E. (1978) Intercellular junctions in the ciliary epithelium. Invest. Opthalmol. Vis. Sci., 17:958-981.
125. Raviola, G., Sagaties, M.J., and Miller, C. (1987) Intercellular junctions between fibroblasts in connective tissues of the eyes of macaque monkeys. A thin section and freeze fracture analysis. Invest. Opthalmol. Vis. Sci., 28:834-841.
126. Rees, P.M. (1967) Observations on the fine structure and distribution of presumptive baroreceptor nerves at the carotid sinus. J. Comp. Neurol., 131:517-548.
127. Rentsch, F.J. (1970) Elektronenmikroskopische Untersuchungen über die interzellulären Verbindungen des unpigmentierten Ciliarepithels in den Hauptverankerungsgebieten des Zonulaapparates. Albrecht v. Graefes Arch. klin. exp. Ophthalmol., 180:113-133.
128. Rentsch, F.J., and van der Zypen, E. (1971) Altersveränderungen der sog. Membrana limitans interna des Ziliarepithels im menschlichen Auge. In: Ageing and Development. Vol. 1. H. Bredt and J.W. Rohen, eds. Schattauer Verlag, Stuttgart, pp. 70-94.
129. Rittig, M., Lütjen-Drecoll, E., Rauterberg, J., Jander, R., and Mollenhauer, J. (1990) Type-VI collagen in the human iris and ciliary body. Cell Tissue Res., 259:305-312.
130. Rittig, M., Flügel, C., Prehm, P., and Lütjen-Drecoll, E. (1993) Hyaluronan synthase immunoreactivity in the anterior segment of the primate eye. Graefe's Arch. Clin. Exp. Ophthalmol., 231:313-317.
131. Rohen, H. (1952) Der Ziliarkörper als funktionelles System. Gegen-baurs Morphol. Jahrb., 92:415-440.
132. Rohen, J.W. (1956) Ober den Ansatz der Ciliarmuskulatur im Bereich des Kammerwinkels. Ophthalmologica, 11:3896-19200.
133. Rohen, J.W. (1962) Sehorgan. In: Primatologica, Handbook of Primatology, Vol. II/1. H. Hofer, A.H. Schultz, and D. Starck, eds. S. Karger, Basel, New York, pp. 6/1-210.
134. Rohen, J.W. (1964) Ciliarkorper (Corpus ciliare). In: Handbuch der Mikroskopischen Anatomie des Menschen. Vol. 3, pt. 4. Haut und Sinnesorgane. Das Auge und Seine Hilfsorgane. W. von Möllendorf and W. Bargmann, eds. Springer-Verlag, Heidelberg, New York, pp. 189-237.
135. Rohen, J.W. (1979) Scanning electron microscopic studies of the zonular apparatus in human and monkey eyes. Invest. Opthalmol. Vis. Sci., 18:133-144.
136. Rohen, J.W. (1982) The evolution of the primate eye in relation to the problem of glaucoma. In: Basic Aspects of Glaucoma Research. E. Lütjen-Drecoll, ed. Schattauer Verlag, Stuttgart, pp. 3-33.
137. Rohen, J.W. (1983) Why is intraocular pressure elevated in chronic simple glaucoma? Anatomical considerations. Ophthalmology, 90: 758-765.
138. Rohen, J.W., Lütjen-Drecoll, E. (1981) Ageing- and non-ageing processes within the connective tissues of the anterior segment of the eye. In: Biochemical and Morphological Aspects of Ageing. W.E.G. Müller and J.W. Rohen, eds. Franz Steiner Verlag GmbH, Wiesbaden, pp. 157-174.
139. Rohen, J.W., and Unger, H.-H. (1958) Studies on the morphology and pathology of the trabecular meshwork in the human eye. Am. J. Ophthalmol., 46:802-813.
140. Rohen J.W., and Unger H.-H. (1959) Zur Morphologie und Pathologie der Kammerbucht des Auges. Abh. Mainzer Akad. der Wiss., math.-nat. Kl. Pt. 3, Franz Steiner Verlag, Wiesbaden.
141. Rohen, J.W., Zimmermann, A. (1970) Altersveränderungen des Ciliarepithels beim Menschen. Albrecht v. Graefes Arch. klin. exp. Ophthalmol., 179:302-317.
142. Rohen, J.W., Lütjen, E., and Bárány, E.H. (1967) The relation between the ciliary muscle and the trabecular meshwork and its importance for the effect of miotics on aqueous outflow resistance. A study in two contrasting monkey species, macaca irus and cercopithecus aethiops. Albrecht v Graefes Arch. Klin. Exp. Ophthalmol., 172:23-47.
143. Rohen, J.W., Futa, R., and Lütjen-Drecoll, E. (1981) The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections. Invest. Opthalmol. Vis. Sci., 21:574-585.
144. Rohen, J.W., Kaufman, P.L., Eichhorn, M., Goeckner, P.A., and Bito, L.Z. (1989) Functional morphology of accommodation in the racoon. Exp. Eye Res., 48:523-537.
145. Rohen, J.W., Eichhorn, M., Kaufman, P.L., and Erickson-Lamy, K.A. (1990) Ciliary neuromuscular morphology in cynomolgus monkeys after ciliary ganglionectomy. Graefe's Arch. Clin. Exp. Ophthalmol., 228:49-54.
146. Ross, R. (1973) The elastic fiber. A review. J. Histochem. Cytochem., 21:199-208.
147. Rother, P., Blume, R., Friedrich, H., and Lochner, M. (1971) Die Veränderung der Muskel-Bindegewebs-Relation des Musculus ciliaris im Laufe des Lebens. Anat. Anz., 129:322-332.
148. Ruprecht, K.W., and Wulle, K.G. (1973) Licht- und elektronenmikroskopische Untersuchungen zur Entwicklung des menschlichen Musculus sphincter pupillae. Albrecht v. Graefes Arch. klin. Exp. Ophthalmol., 186:117-130.
149. Ruskell, G.L. (1973) Sympathetic innervation of the ciliary muscle in monkeys. Exp. Eye Res., 16:183-190.
150. Ruskell, G.L. (1982) Innervation of the anterior segment of the eye. In: Basic Aspects of Glaucoma Research, E. Lütjen-Drecoll, ed. Schattauer Verlag, Stuttgart, New York, pp. 49-66.
151. Ruskell, G.L., and Griffiths, T. (1979) Peripheral nerve pathway to the ciliary muscle. Exp. Eye Res., 28:277-284.
152. Salzmann, M. (1912) Anatomie und Histologie des menschlichen Augapfels im Normalzustande. Seine Entwicklung und sein Altern, Franz Deuticke, Leipzig.
153. Schlötzer-Schrehardt, U., and Dorfler, S. (1993) Immunolocalization of growth factors in the human ciliary body epithelium. Curr Eye Res., 12:893-905.
154. Schlötzer-Schrehardt, U., Müller, H.-G., Wirtz, M., and Naumann, G.O.H. (1990a) Desmosomal-mitochondrial complexes in human nonpigmented ciliary and retinal pigment epithelia. Invest. Opthalmol. Vis. Sci., 31:664-669.
155. Schlötzer-Schrehardt, U., Wirtz, P.M., Müller, H.-G., Lang, G.K., and Naumann, G.O.H. (1990b) Morphometrische Analyse altersabhängiger Veränderungen des menschlichen Ziliarkörpers. Fortschr. Ophthalmol., 87:59-68.
156. Schoultz, T. W., and Swett, J.E. (1972) The fine structure of the Golgi tendon organ. J. Neurocytol., 1:1-26.
157. Schulze, F.E. (1867) Der Ciliarmuskel des Menschen. Arch. Mikroskop. Anat., 3:477-499.
158. Shiose, Y. (1970) Electron microscopic studies on blood retinal and blood-aqueous barriers. Jpn. J. Ophthalmol, 14:73-87.
159. Shiose, Y., and Sears, M. (1965) Localization and other aspects of the histochemistry of nucleoside phosphatases in the ciliary epithelium of albino rabbits. Invest. Opthalmol. Vis. Sci., 4:64-75.
160. Shiose, Y., and Sears, M. (1966) Fine structural localization of nucleoside phosphatase activity in the ciliary epithelium of albino rabbits. Invest. Opthalmol. Vis. Sci., 5:152-165.
161. Smith, R.S. (1971) Ultrastructural studies of the blood aquous barrier. I. Transport of an electron-dense tracer in the iris and ciliary body of the mouse Am. J. Ophthalmol., 71:1066-1077.
162. Smith, R.S., and Rudt, L.A. (1973) Ultrastructural studies of the blood-aqueous barrier. 2. The barrier to horseradish peroxidase in primates. Am. J. Ophthalmol, 76:937-947.
163. Somlyo, A.P., Somlyo, A.V., and Shuman, H. (1979) Electron probe analysis of vascular smooth muscle. J. Cell Biol., 81:316-335.
164. Stieve, R. (1949) Über den Bau des menschlichen Ziliarmuskels, seine physiologischen Veränderungen wahrend des Lebens und seine Bedeutung fur die Akkommodation. Z. mikrosk. -Anat. Forsch., 55:3-88.
165. Stone, R.A. (1986) Neuropeptide Y and the innervation of the human eye. Exp. Eye Res., 42:349-355.
166. Stone, R.A., and Kuwayama, Y (1985) Substance P-like immunoreactive nerves in the human eye. Arch. Ophthalmol., 103:1207-1211.
167. Stone, R.A., and McGlinn, A.M. (1988) Calcitonin gene-related peptide immunoreactive nerves in human and rhesus monkey eyes. Invest. Opthalmol. Vis. Sci , 29:305-310.
168. Stone, R.A., Tervo, T., Tervo, K., and Tarkkanen, A. (1986) Vasoactive intestinal polypeptide-like immunoreactive nerves to the human eye. Acta Ophthalmol., 64:12-18.
169. Sugita, A., Yoshioka, H., and Okita, T. (1983) Innervation of melanocytes in the choroid. Jpn. J. Ophthalmol., 27:609-615.
170. Tamm, E., Lütjen-Drecoll, E., and Rohen, J.W. (1990) Age-related changes of the ciliary muscle in comparison with changes induced by treatment with prostaglandin F2α. An ultrastructural study in rhesus and cynomolgus monkeys. Mech. Ageing Develop., 51:101-120.
171. Tamm, E., Flügel, C., Baur, A., and Lütjen-Drecoll, E. (1991a) Cell cultures of human ciliary muscle: Growth, ultrastructural and immunocytochemical characteristics. Exp. Eye Res., 53:375-387.
172. Tamm, E., Lütjen-Drecoll, E., Jungkunz, W., and Rohen, J,W. (1991b) Posterior attachment of ciliary muscle in young, accommodating old, presbyopic monkeys. Invest. Opthalmol. Vis. Sci., 32:1678-1692.
173. Tamm, E., Baur, A., and Lütjen-Drecoll, E. (1992a) Synthesis of extracellular matrix components by human ciliary muscle cells in culture. Curr. Eye Res., 11:333-341.
174. Tamm, E., Croft, M.A., Jungkunz, W., Lütjen-Drecoll, E., and Kaufman, P. (1992b) Age-related loss of ciliary muscle mobility in the rhesus monkey. Role of the choroid. Arch. Ophthahnol., 110: 871-876.
175. Tamm, E., Flügel, C., Stefani, F.H., and Rohen, J.W. (1992c) Contractile cells in the human scierai spur. Exp. Eye Res., 54:531-543.
176. Tamm, E., Flügel, C., Stefani, F.H., and Lütjen-Drecoll, E. (1994) Nerve endings with structural characteristics of mechanoreceptors in the human scleral spur. Invest. Opthalmol. Vis. Sci., 35:1157-1166.
177. Tamm, S., Tamm, E., and Rohen, J.W. (1992) Age-related changes of the human ciliary muscle. A quantitative morphometric study. Mech. Ageing Develop., 62:209-221.
178. Törnqvist, G. (1966) Effect of cervical sympathetic stimulation on accommodation in monkeys. Acta Physiol. Scand., 67:363-372.
179. Törnqvist, G. (1967a) Accommodation in monkeys. Some pharmacological and physiological aspects. Acta Ophthalmol., 45:1-32.
180. Törnqvist, G. (1967b) The relative importance of the parasympathetic and sympathetic nervous system for accommodation in monkeys. Invest. Opthalmol. Vis. Sci., 6:612-617.
181. Tranum-Jensen, J. (1975) The ultrastructure of the sensory end-organs (baroreceptors) in the atrial endocardium of young mini-pigs. J. Anat., 119:255-275.
182. Uehara Y., Campbell R., and Burnstock, G. (1976) Muscle and Its Innervation. An Atlas of Fine Structure. Edward Arnold Publishers Limited, London.
183. Uga, S. (1967) Electron microscopic studies of motor nerve endings in the ciliary muscle of human and monkey eyes. Jpn. J. Ophthalmol, 11:121-132.
184. Unger, W.G. (1989) Mediation of the ocular response to injury and irritation: Peptides versus prostagiandins. In: The Ocular Effects of Prostaglandins and Other Eicosanoids. Proceedings in Clinical and Biological Research. Vol. 312. L.Z. Bito and J. Stjernschantz, eds. Alan R. Liss, New York, pp. 293-328.
185. van Alphen, G.W.H.M., Robinette, S.L., and Macri, F.J. (1962) Drug effects on ciliary muscle and choroid preparations in vitro. Arch. Ophthalmol., 68:81-93.
186. van der Zypen, E. (1967) Licht- und elektronenmikroskopische Untersuchungen über den Bau und die Innervation des Ziliarmuskels bei Mensch und Affe (Cercopithecus ethiops). Albrecht v. Graefes Arch. Klin. Exp. Ophthalmol., 174:143-168.
187. van der Zypen, E. (1978) Licht- und elektronenmikroskopische UntersuchungenüberdieAltersveränderungenamM.ciliarisimmenschlichen Auge. Albrecht v. Graefes Arch. klin. exp. Ophthalmol., 205: 245-253.
188. van der Zypen, E., and Renisch, F.J. (1971) Altersbedingte Veranderungen am Ziliarepithel des Auges. In: Ageing and Development. Vol. 1. H Bredt and J.W. Rohen, eds. Schattauer Verlag, Stuttgart, pp. 37-69.
189. Varndell, I.M., and Polak, J.M. (1988) The ultrastructure of peptide-containing neurons. In: Handbook of Chemical Neuroanatomy, Vol. 6: The Peripheral Nervous System. A. Bjorklund, T. Hökfelt, and C. Owman, eds. Elsevier Science Publishers, B.V., Amsterdam, pp. 143-159.
190. Vegge, T. (1971) An epithelial blood-aqueous barrier to horseradish peroxidase in the processes of the newt monkey (Cercopithecus aethiops). Z. Zellforsch., 114:309-320.
191. Vegge, T, and Ringvold, A. (1971) The ultrastructure of the extracellular components of the trabecular meshwork in the human eye. Z. Zellforsch., 11:361-376.
192. von During, M., Andres, K.H., and Iravant, J. (1974) The fine structure of the pulmonary stretch receptor in the rat. Z. Anat. Entwickl.-Gesch., 143:215-222.
193. Warwick, R. (1954) The ocular parasympathetic nerve supply and its mesencephalie sources. J. Anat., 88:195-203.
194. Weale, R.A. (1962) Presbyopia. Brit. J. Ophthalmol., 46:660-668.
195. Wegener, K. (1967) Regional differences in ultrastructure of the rabbit ciliary process: The effect of anesthetics and fixation procedures. Invest. Opthalmol. Vis. Sci., 6:177-191.
196. Weingeist, T.A. (1970) The structure of the developing and adult ciliary complex of the rabbit eye: A gross, light and electron microscopic study. Doc. Ophthalmol., 28:205-357.
197. Westheimer, G., and Blair, S.M. (1973) The parasympathetic pathways to internal eye muscles. Invest. Ophthalmol. Vis. Sci., 12: 193-197.
198. Westsmith, R.A., and Abernethy, R.E. (1954) Detachment of retina with use of diisopropyl fluorophosphate (Fluorpryl) in treatment of glaucoma. Arch. Ophthalmol., 52:779.
199. Wistrand, P.J., Schenholm, M., and Lönnerholm, G. (1986) Carbonic anhydrase isoenzyrnes CAI and CAII in the human eye. Invest. Opthalmol. Vis. Sci., 27:419-428.
200. Yamada, E. (1989) Further observation on the intraepithelial nerve fibers of rabbit ocular ciliary epithelium. Arch. Histol. Cytol., 52: 191-195.