Thymic B cells of pig fetuses and germ-free pigs spontaneously produce IgM, IgG and IgA: Detection by ELISPOT method

Immunology

Volumn 87, Issue 3, 1996, Pages 487-492

  Cukrowska, B ^a   Sinkora J ^a   Mandel, L ^a   Splichal I ^a   Bianchi, A T J ^b   Kovaru F ^c   Tlaskalova Hogenova H ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; FETUS; IMMUNOASSAY; IMMUNOGLOBULIN PRODUCTION; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; SWINE; THYMUS;

EID: 0029875256     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1996.499573.x     Document Type: Article

References (31)

1. BENNER R., MEIMA F., VAN DER MEULEN G.M. & VAN EWIJK W. (1974) Antibody formation in mouse bone marrow. III. Effects of route of priming and antigen dose. Immunology 30, 449.
2. ANDREU-SANCHEZ J.L., FARO J., ALONSO J.M., PAIGE Ch. J., MARTINEZ A.C. & MARCOS M. (1990) Ontogenic characterization of thymic B lymphocytes. Analysis in different mouse strains. Eur J Immunol 20, 1767.
3. ISAACSON P.G., NORTON A.J. & ADDIS B.J. (1987) The human thymus contains a novel population of B lymphocytes. Lancet 2, 1488.
4. SPENCER J., CHOY M., HUSSELL T., PAPADAKI J. & ISAACSON P.G. (1992) Properties of human thymic B cells. Immunology 75, 596.
5. NANGO K.-I., INABA M., ADACHI Y. et al. (1991) Ontogeny of thymic B cells in normal mice. Cell Immunol 133, 109.
6. INABA M., KUMA S., INABA K. et al. (1988) Unusual phenotype of B cells in the thymus of normal mice. J Exp Med 168, 811.
7. THAN S., INABA M., INABA K., FUKUBA Y., ADACHI Y. & IKEHARA S. (1992) Origin of thymic and peritoneal Ly-1 B cells. Eur J Immunol 22, 1299.
8. + human thymic B cell subset. J Immunol 151, 1008.
9. KEARNEY J. & VAKIL M. (1986) Idiotype-directed interactions during ontogeny play a major role in the establishment of the adult B cell repertoire. Immunol Rev 94, 39.
10. COUTINHO A. & KAZATCHKINE M.D. (1994) Autoimmunity. Physiology & Disease pp. 57-129. Wiley-Liss, Inc., New York.
11. ŠTERZL J., REJNEK J. & TRAVNIČEK J. (1965) Impermeability of pig placenta for antibodies. Folia Microbiol 11, 7.
12. TLASKALOVÁ-HOGENOVÁ H., ŠTERZL J., ŠTËPANKOVÁ R. et al. (1983) Development of immunological capacity under germfree and conventional conditions. Ann NY Acad Sci 409, 96.
13. FRANĚK F., RIHA I. & ŠTERZL J. (1961) Characterisation of gamma-globulin, lacking antibody properties in newborn pigs. Nature 189, 1020.
14. TLASKALOVÁ-HOGENOVÁ H., MANDEL L., TREBICHAVSKY L., KOVAŘŮ F., BAROT R. & ŠTERZL J. (1994) Development of immune responses in early pig ontogeny. Vet Immunol Immunopathol 43, 135.
15. TLASKALOVÁ-HOGENOVÁ H., MANDEL L., ŠIMEČKOVÁ J., BAROT-CIOBARU R., ŠTERZL J. & REJNEK J. (1987) Occurrence of cells spontaneously secreting immunoglobulins and polyclonal B cell activation in germfree (GF) piglets during ontogeny. In: Gnotobiology and Its Applications (ed. R. De Cluzo), p. 781. Gnotobiological Society, Versailles, France.
16. PROKEŠOVÁ L., TREBICHAVSKY I., KOVAŘŮ F., KOSTKA J. & REJNEK J. (1981) Ontogeny of immunoglobulin synthesis. Production of IgM, IgG and IgA in pig foetuses. Dev Comp Immunol 5, 491.
17. BIANCHI A.T.J., ZWART R.J., JEURISSEN S.H.M. & MOONEN-LEUSEN H.W.M. (1992) Development of the B- and T-cell compartments in porcine lymphoid organs from birth to adult life: an immunohistological approach. Vet Immunol Immunopathol 33, 201.
18. TRAVNIČEK J., MANDEL L., LANC A. & RŮŽIČKA R. (1966) Rearing of germfree piglets [in Czech]. Čs Fysiologie 15, 140.
19. DVOŔAK P., DVOR̈AKOVÁ D., HRUBAŇ V., HOŔAK V. & STANÉK R. (1986) Monoclonal antibodies specific for pig serum and cell surface IgM. Res Vet Sci 41, 356.
20. VAN ZAANE D. & HULST M.M. (1987) Monoclonal antibodies against porcine immunoglobulin isotypes. Vet. Immunol Immunopathol 16, 23.
21. CZERKINSKY C., NILSON L.A., NYGREN H., OUCHTERLONY O. & TARKOWSKI A. (1983) A solid phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J Immunol Meth 65, 109.
22. BINNS R.M. & PABST R. (1994) Lymphoid tissue structure and lymphocyte trafficking in the pig. Vet Immunol Immunopathol 43, 792.
23. + B cells. Responsiveness to Major Histocompatibility Complex class II-restricted T blasts but not lipopolysaccharide or anti-IgM plus interleukin 4. J Exp Med 171, 321.
24. ROUSSET F., GARCIA E. & BANCHEREAU J. (1991) Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen. J Exp Med 173, 705.
25. KROCZEK R.A., GRAF D., BRUGNONI D. et al. (1994) Defective expression of CD40 ligand on T cells causes 'X-linked immunodefficiency with hyper-IgM (HIDMI)'. Immunol Rev 138, 39.
26. CUKROWSKA B., ŠINKORA J., ŘEHAKOVÁ Z. et al. (1995) Polyclonal immunoglobulin response of thymic, liver and splenic lymphocytes from fetal, germ-free and conventionally reared pigs to different B cell activators. Folia Microbiol, 40, 421.
27. HAYAKAVA K., HARDY R.R., HONDA M., HERZENBERG L.A., STEINBERG A.D. & HERZENBERG L. (1984) Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc Natl Acad Sci USA 81, 2494.
28. INABA M., INABA K., HOSONO M. et al. (1991) Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells. J Exp Med 173, 54.
29. MAZDA O., WATANABE Y., GYOTOKU J. I. & KATSURA Y. (1991) Requirement of dentritic cells and B cells in clonal deletion of MLs-reactive T cells in the thymus. J Exp Med 173, 539.
30. CUKROWSKA B., TLASKALOVÁ H., ŠINKORA J., ŠPLICHAL I., BIANCHI A.T.J. & AVRAMEAS S. (1994) Development of B cells in early ontogeny of pigs. 12th European Immunology Meeting, Barcelona, abstract 02/25, p. 10.
31. TLASKALOVÁ-HOGENOVÁ H., MANDEL L., ŠTÈPANKOVÁ R. et al. (1992) Autoimmunity: from physiology to pathology. Natural antibodies, mucosal immunity and development of B cell repertoire. Folia Biol 38, 202.