Effect of total parenteral nutrition containing lipid calories on hepatic drug metabolism in rats

Drug Metabolism and Disposition

Volumn 24, Issue 4, 1996, Pages 502-505

  Raftogianis, Rebecca B ^b   Franklin, Michael R ^b   Galinsky, Raymond E ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTASIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG CONJUGATION; DRUG METABOLISM; ENZYME ANALYSIS; FAT INTAKE; LIPID METABOLISM; LIVER METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; TOTAL PARENTERAL NUTRITION; TRANSAMINATION;

ACETAMINOPHEN; ANIMALS; FATTY ACIDS; LIVER; MALE; PARENTERAL NUTRITION, TOTAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029875171     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. S. Klein and W. H. Nealon: Hepatobiliary abnormalities associated with total parenteral nutrition. Semin. Liver Dis. 8, 237-246 (1988).
2. G. F. Sheldon, S. R. Peterson, and R. Sanders: Hepatic dysfunction during hyperalimentation. Arch. Surg. 113, 504-508 (1978).
3. A. L. Baker and I. H. Rosenberg: Hepatic complications of total parenteral nutrition. Am. J. Med. 82, 489 (1987).
4. S. Li, M. S. Nussbaum, D. Teague, C. L. Gapen, R. Dayal, and J. E. Fischer: Increasing dextrose concentrations in total parenteral nutrition (TPN) causes alterations in hepatic morphology and plasma levels of insulin and glucagoa in rats. J. Surg. Res. 44, 639-48 (1988).
5. S. Li, M. S. Nussbaum, D. W. McFadden, C. L. Gapen, R. Dayal, and J. E. Fischer: Addition of glucagon to total parenteral nutrition (TPN) prevents hepatic steatosis in rats. Surgery 104, 350-357 (1988).
6. R. L. Fisher: Hepatobiliary abnormalities associated with total parenteral nutrition. Gastroenterol. Clin. North Am. 18, 645-66 (1989).
7. A. R. Pulito, T. V. Santulli, H. J. Wigger, M. A. Bieber, and W. C. Heird: Effects of total parenteral nutrition and semi-starvation on the liver of beagle puppies. J. Pediatr. Surg. 11, 655-663 (1976).
8. R. G. Knodell, N. M. Steele, F. B. Cerro, J. B. Gross, and T. E. Solomon: Effects of parenteral and enteral hyperalimentation on hepatic drug metabolism in the rat. J. Pharmacol. Exp. Ther. 229, 589-597 (1984).
9. R. G. Knodell, D. G. Wood, and F. P. Guengerich: Selective alteration of constitutive hepatic cytochrome P-450 enzymes in the rat during parenteral hyperalimentation. Biochem. Pharmacol. 38, 3341-3345 (1989).
10. R. B. Raftogianis, M. R. Franklin, and R. E. Galinsky: The depression of hepatic conjugation reactions in rats after lipid-free total parenteral nutrition administered via the portal vein. J. Parenter. Enter. Nutr. 19, 303-309 (1995).
11. L. H. Ross, L. Griffeth, R. I. Hall, M. G. Bozovic, E. Rauckman, and J. P. Grant: Hepatotoxic effects of parenteral nutrition upon the in vivo pharmacokinetics of antipyrine. Surg. Forum 34, 34-36 (1983).
12. R. I. Hall, J. P. Grant, L. H. Ross, R. A. Coleman, M. G. Bozovic, and S. H. Quarfordt: Pathogenesis of hepatic steatosis in the parenterally fed rat. J. Clin. Invest. 74, 1658-1668 (1984).
13. S. Meurling and K. A. Roos: Liver changes in rats on continous and intermittent parenteral nutrition with and without fat (Intralipid 20%). Acta Chir. Scand. 147, 475-480 (1981).
14. M. S. Nussbaum, S. Li, R. H. Bower, D. W. McFadden, R. Dayal, and J. E. Fischer: Addition of lipid to total parenteral nutrition prevents hepatic steatosis in rats by lowering portal venous insulin/glucagon ratio. J. Parenter. Enter. Nutr. 16, 106-109 (1992).
15. M. J. Koruda, R. H. Rolandelli, D. Z. Bliss, J. Hastings, J. L. Rombeau, and R. G. Settle: Parenteral nutrition supplemented with short-chain fatty acids: Effect on the small bowel mucosa in normal rats. Am. J. Clin. Nutr. 51, 685-689 (1990).
16. W. P Norred and A. E. Wade: Dietary fatty acid-induced alterations of hepatic microsomal drug metabolism. Biochem. Pharmacol. 21, 2887-2897 (1972).
17. A. J. Dannenberg and E. K. Yang: Effect of dietary lipids on levels of UDP-glucuronosyltransferase in liver. Biochem Pharmacol. 44, 335-340 (1992).
18. A. J. Dannenberg and D. Zakim: Dietary lipid regulates the amount and functional state of UDP-glucuronosyltransferase in rat liver. J. Nutr. 122, 1607-1613 (1992).
19. P. Burgess, R. I. Hall, D. N. Bateman, and I. D. A. Johnston: The effect of total parenteral nutrition on hepatic drug oxidation. J. Patenter. Enter. Nutr. 11, 540-543 (1987).
20. R. G. Knodell, D. I. Whitmer, and R. T. Holman: Influence of hyperalimentation on rat hepatic microsomal fluidity and function. Gastroenterology 98, 1320-1325 (1990).
21. G. B. Corcoran, E. L. Todd, W. J. Racz, H. Hughes, C. V. Smith, and J. R. Mitchell: Effects of N-acerylcysteine on the disposition and metabolism of acetaminophen in mice. J. Pharmacol. Exp. Ther. 232, 857-863 (1985).
22. M. Gibaldi and D. Perrier: "Pharmacokinetics," pp. 1-42. Marcel Dekker, Inc., New York, 1982.
23. M. R. Franklin and R. W. Estabrook: On the inhibitory action of mersalyl on microsomal drug oxidation. Arch. Biochem. Biophys. 143, 318-329 (1971).
24. O. H. Lowry, N. J. Rosebrough, A. L. Fair, and R. J. Randall: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275 (1951).
25. W. H. Habig, M. J. Pabst, and W. B. Jakoby: Glutathione-S-transferase: the first step in mercapturic acid formation. J. Biol. Chem. 249, 7130-7139 (1974).
26. J. K. Ritter and M. R. Franklin: Induction and inhibition of rat hepatic drug metabolism by N-substituted imidazole drugs. Drug Metab. Dispos. 15, 335-343 (1987).
27. T. Omura and R. Sato: The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239, 2370-2378 (1964).
28. K. J. Netter and O. Seidel: An adaptively stimulated O-demethylating system in rat liver microsomes and its kinetic properties. J. Pharmacol. Exp. Ther. 146, 61-65 (1964).
29. J. Zar: "Biostatistical Analysis," pp. 122-149. Prentice Hall, Englewood Cliffs, NJ, 1984.
30. S. Hata, S. Kamata, R. Nezu, Y. Takagi, and A. Okada: A newborn rabbit model for total parenteral nutrition: effects of nutritional components on cholestasis. J. Parenter. Enter. Nutr. 13, 265-271 (1989).
31. S. F. Lowry and M. F. Brennan: Abnormal liver function during parenteral nutrition: relation to infusion excess. J. Surg. Res. 26, 300-307 (1979).
32. R. J. Shulman, M. L. Fiorotto, H. P. Sheng, M. J. Finegold, and C. Garza: Liver composition and histology in growing infant miniature pigs given different total parenteral nutrition fuel mixes. J. Parenter. Enter. Nutr. 11, 275-279 (1987).
33. G. F. Whalen, R. C. Shamberger, A. Perez-Atayde, and J. Follonan: A proposed cause for the hepatic dysfunction associated with parenteral nutrition. J. Pediatr. Surg. 25, 622-626 (1990).
34. R. B. Raftogianis, M. R. Franklin, and R. E. Galinsky: The effect of lipid-free total parenteral nutrition on hepatic drug conjugation in rats. J. Pharmacol. Exp. Ther. 276, 602-608 (1996).
35. R. G. Knodell, D. I. Whitmer, R. T. Holman, N. M. Steele. M. Watson, and S. Johnson: Discordance between microsomal membrane drug metabolizing activity and membrane fluidity and fatty acid composition in hyperalimented rats. Gastroenterology 92, 1744 (abstr.) (1987).