Potent inhibitors of acyl-CoA:Cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides

Journal of Medicinal Chemistry

Volumn 39, Issue 6, 1996, Pages 1262-1270

  Kataoka, Ken Ichiro ^a   Shiota, Tatsuki ^a   Takeyasu, Takumi ^a   Minoshima, Toru ^a   Watanabe, Kenzo ^a   Tanaka, Hiroko ^a   Mochizuki, Tsutomu ^a   Taneda, Keiko ^a   Ota, Mikio ^a   Tanabe, Hirofumi ^a   Yamaguchi, Hisao ^a  

^a TEIJIN LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,2 DIMETHYL N (2,4,6 TRIMETHOXYPHENYL)DODECANAMIDE; 6 (4 CHLOROPHENOXY) N (2,3 DIHYDRO 2,2,4,6 TETRAMETHYLBENZOFURAN 7 YL) 2,2 DIMETHYLOCTANAMIDE; AMIDE; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CP 113818; HYPOCHOLESTEROLEMIC AGENT; N (2,3 DIHYDRO 2,2,4,6 TETRAMETHYLBENZOFURAN 7 YL) 2,2 DIMETHYLDODECANAMIDE; N (5 DIMETHYLAMINO 2,3 DIHYDRO 2,2,4,6 TETRAMETHYLBENZOFURAN 7 YL] 2,2 DIMETHYLDODECANAMIDE; N (7 DECYLOXY 4 OXOCHROMAN 8 YL) 2,2 DIMETHYLPROPIONAMIDE; N (7 METHOXY 4 OXOCHROMAN 8 YL) 2,2 DIMETHYLDODECANAMIDE; N [2,4 BIS(METHYLTHIO) 6 METHYL 3 PYRIDINYL] 2 (HEXYLTHIO)DECANAMIDE; TEI 6522; TEI 6620; TEI 6657; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CHOLESTEROL DIET; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG POTENCY; ENZYME INHIBITION; FOAM CELL; HYPERCHOLESTEROLEMIA; LIPOPHILICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PERITONEUM MACROPHAGE; RABBIT; RAT; REVIEW; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BENZOFURANS; DOGS; ENZYME INHIBITORS; RABBITS; RATS; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029875106     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950828+     Document Type: Article

References (20)

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