Mitochondrial FAD-glycerophosphate dehydrogenase and G-protein-coupled inwardly rectifying K+ channel: No evidence for linkage in maturity-onset diabetes of the young or NIDDM

Diabetes

Volumn 45, Issue 5, 1996, Pages 639-641

  Warren Perry, Margaret G ^a   Stoffel, Markus ^b   Saker, Philip J ^a   Zhang, Yun ^a   Brown, Louise J ^c   MacDonald, Michael J ^c   Turner, Robert C ^a  

^a RADCLIFFE INFIRMARY   (United Kingdom)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FLAVINE ADENINE NUCLEOTIDE; GLUCOSE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; GLYCEROPHOSPHATE; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; POTASSIUM CHANNEL; POTASSIUM ION;

ARTICLE; CHROMOSOME 2Q; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; HUMAN TISSUE; INSULIN RELEASE; MATURITY ONSET DIABETES MELLITUS; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; PEDIGREE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TANDEM REPEAT;

EID: 0029874314     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.5.639     Document Type: Article

References (18)

1. Kubo Y, Reuveny E, Slesinger PA, Jan YN, Jan LY. Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature 364:802-806, 1993
2. Stoffel M, Espinosa R, Powell KL, Philipson LH, Le Beau MM, Bell GI: Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCN J3): localisation to chromosome 2 and identification of a simple tandem repeat polymorphism. Genomics 21:254-256, 1994
3. + channel proteins. Nature 374:135-141, 1995
4. Tsaur M-L, Menzel S, Lai F-P, Espinosa R III, Concannon P, Spielman RS, Hanis C, Cox NJ, Le Beau MM, German MS, Jan LY, Bell GI, Stoffel M: Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localisation of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM. Diabetes 44:592-596, 1994
5. Zhang Y, Warren-Perry M, Sakura H, Adelman J, Stoffel M, Bell GI, Ashcroft FM, Turner RC: No evidence for mutations in a putative β-cell ATP-sensitive K+ channel subunit in MODY, NIDDM or GDM. Diabetes 44:597-600, 1994
6. Brown LJ, MacDonald MJ, Lehn DA, Moran S: Sequence of rat mitochondrial glycerol-3-phosphate dehydrogenase cDNA: evidence for EF-hand calcium-binding domains. J Biol Chem 269:14363-14366, 1994
7. Brown LJ, Stoffel M, Moran S, Lehn DA, Pomije C, LeBeau MM, McDonald MJ: Structure of the mitochondrial glycerol-3-phosphate dehydrogenase gene and mapping to chromosome 2 (Abstract). Am J Human Genet. 57:A141, 1995
8. Giroix MH, Rasschaert J, Bailbe D, Leclercq-Meyer V, Sener A, Portha B, Malaisse WJ: Impairment of glycerol phosphate shuttle in islets from rats with diabetes induced by neonatal streptozocin. Diabetes 40:227-232, 1991
9. Ostenson CG, Abdel-Halim SM, Rasschaert J, Malaisse-Lagae F, Meuris S, Sener A, Efendic S, Malaisse WJ: Deficient activity of FAD-linked glycerophosphate dehydrogenase in islets of GK rats. Diabetologia 36:722-726, 1993
10. Sener A, Herberg L, Malaisse WJ: FAD-linked glycerophosphate dehydrogenase deficiency in pancreatic islets of mice with hereditary diabetes. FEBS Lett 316:224-227, 1993
11. Malaisse WJ, Malaisse-Lagae F, Kukel S, Reinhold U, Sener A: Could non-insulin-dependent diabetes mellitus be attributable to a deficiency of FAD-linked glycerophosphate dehydrogenase? Biochem Med Metab Biol 50:226-232, 1993
12. Fernandez-Alvarez J, Conget I, Rasschaert J, Sener A, Gomis R, Malaisse WJ: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients. Diabetologia 37:177-181, 1994
13. Zhang Y, Warren-Perry M, Saker PJ, Hattersley AT, Mackie ADR, Baird JD, Greenwood RH, Stoffel M, Bell GI, Turner RC. Candidate gene studies in pedigrees with maturity onset diabetes of the young characterized by more severe diabetes than that associated with glucokinase mutations. Diabetologia 38:1055-1060, 1995
14. Vaxillaire M, Boccio V, Phillipi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Vehlo G, Lathrop GM, Froguel P: A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Nat Genet 9:418-423, 1995
15. Tattersall RB: Mild familial diabetes with dominant inheritance. Q J Med 43:339-357, 1974
16. UKPDS Group: UK Prospective Diabetes Study. VIII: study design, progress and performance. Diabetologia 34:877-890, 1991
17. Maniatis T, Frisch EF, Sambrook J (Eds): Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1982
18. Zhang Y, Cook JTE, Hattersley AT, Firth R, Saker PJ, Warren-Perry M, Stoffel M, Turner RC: Non-linkage of the glucagon-like peptide receptor gene with maturity onset diabetes of the young. Diabetologia 37:721-724, 1994