Indirect allorecognition of HLA class I peptides by CD4+ cytolytic T lymphocytes

Human Immunology

Volumn 46, Issue 1, 1996, Pages 1-9

  Susskind, B ^a,b   Iannotti, Michael R ^a   Shornick, Michael D ^a   Steward, Nancy S ^a   Gorka, John ^a   Mohanakumar, T ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; HLA A1 ANTIGEN; HLA ANTIGEN CLASS 1; HLA B8 ANTIGEN; HLA DQ ANTIGEN; HLA DR1 ANTIGEN; HLA DR4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN;

ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HLA SYSTEM; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0029873962     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/0198-8859(95)00215-4     Document Type: Article

References (40)

1. Chen BP, Madrigal A, Parham P: Cytotoxic T cell recognition of an endogenous class I HLA peptide presented by a class II molecule. J Exp Med 172:779, 1990.
2. Lafferty K, Prowse S, Simeonovic C, et al: Paul WE, Pathman CG, Metzgar H (eds); Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept, Palo Alto; Annual Reviews, 1983, p 143.
3. Benichou G, Takizawa PA, Olson CA, McMillan M, Sercarz EE: Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection. J Exp Med 175:305, 1992.
4. Lee RS, Grusby MJ, Glimcher LH, Winn HJ, Auchincloss HJ: Indirect recognition by helper T cells can induce donor-specific cytotoxic T lymphocytes in vivo. J Exp Med 179:865, 1994.
5. Benichou G, Fedoseyeva E, Lehmann PV, Olson CA, McMillan M, Sercarz EE: Limited T cell response to donor MHC peptides during allograft rejection: implications for selective immune therapy in transplantation. J Immunol 153:938, 1994.
6. Jenkins M: The role of cell division in the induction of clonal anergy. Immunol Today 13:69, 1992.
7. Miller JFAP, Morahan G: Peripheral T cell tolerance. Annu Rev Immunol 10:51, 1992.
8. Fangmann J, Dalchau R, Fabre J: Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides. J Exp Med 17 5: 1521, 1992.
9. Terasaki PI, Brenoco D, Park MS, et al: Microdroplet testing for HLA-A, B, C and DR antigens. Am J Clin Pathol 27:61, 1987.
10. Hadley GA, Mohanakumar T: Kidney cell-restricted recognition of MHC class I alloantigens by human cytolytic T-cell clones. Transplantation 55:400, 1993.
11. Barany G, Merrifield RB, Gross E, Meienhofer J (eds); In: Solid phase peptide synthesis. The Peptides, New York, Academic Press, 1979, p 1.
12. Strack P, Martin C, Saito S, Dekruyff RH, Ju S-T: Metabolic inhibitors distinguish cytolytic activity of CD4 and CD8 clones. Eur J Immunol 20:179, 1990.
13. + T cell-mediated cytotoxicity. J Immunol 152:1127, 1994.
14. Smyth MJ, Norihisa Y, Ortaldo JR: Multiple cytolytic mechanisms displayed by activated human peripheral blood T cell subsets. J Immunol 148:55, 1992.
15. + T cell subsets: the role of granule exocytosis. J Immunol 151:740, 1993.
16. Chicz RM, Urban RG, Gorga JC, Vignali DAA, Lane WS, Strominger JL: Specificity and promiscuity among natural processed peptides bound to HLA-DR alleles. J Exp Med 178:27, 1993.
17. Liu Z, Braunstein NS, Suciu-Foca N: T cell recognition of allopeptides in context of syngeneic MHC. J Immunol 148:35, 1992.
18. Harris P, Liu Z, Suciu-Foca N: MHC class II binding of peptides derived from HLA-DR 1. J Immunol 148:2169, 1992.
19. Clayberger C, Lyu SC, Pouletty P, Krensky AM: Peptides corresponding to T-cell receptor-HLA contact regions inhibit class I-restricted immune responses. Transplant Proc 25:447, 1993.
20. Schneck J, Munitz T, Coligan JE, Maloy WL, Margulies DH, Singer A: Inhibition of allorecognition by an H-2Kb-derived peptided is evidence for a T cell binding region on a major histocompatibility complex molecule. Proc Natl Acad Sci USA 86:8516, 1989.
21. Marshall KW, Liu AF, Canales J, Perahia B, Jorgensen B, Gantzos RD, Aguilar B, Devaux B, Rothbard JB: Role of the polymorphic residues in HLA-DR molecules in allele-specific binding of peptide ligands. J Immunol 152:4946, 1994.
22. Sercarz EE, Lehmann PV, Ametani A, Benichou G, Miller A, Moudgil K: Dominance and crypticity of T cell antigenic determinants. Annu Rev Immunol 11:729, 1993.
23. Starzl TE, Demetris AJ, Murase N, Thomson AW, Trucco M, Ricordi C: Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation. Immunol Today 14:326, 1993.
24. Parker K, Dalchau R, Fowler V, Priestley C, Catter C, Fabre J: Stimulation of CD4+ T lymphocytes by allogeneic MHC peptides presented on autologous antigen-presenting cells. Transplantation 53:918, 1992.
25. Mathew JM, Marsh JW, Susskind B, Mohanakumar T: Analysis of T cell responses in liver allograft recipients: evidence for deletion of donor specific cytotoxic T cells in the peripheral circulation. J Clin Invest 91:900, 1993.
26. Schulick RD, Weir MB, Miller MW, Cohen DJ, Bermas BL, Shearer GM: Longitudinal study of in vitro CD4+ T helper cell function in recently transplanted renal allograft patients undergoing tapering of their immunosuppressive drugs. Transplantation 56:590, 1993.
27. Braakman E, Rotteveel FTM, van Bleek G, van Seventer GA, Lucas CJ: Are MHC class II-restricted cytotoxic T lymphocytes important? Immunol Today 8:265, 1987.
28. Ottenhoff T, Mutis T: Specific killing of cytotoxic T cells and antigen-presenting cells by CD4+ cytotoxic T cell clones: a novel potentially immunoregulatory T-T cell interaction in man. J Exp Med 171:2011, 1990.
29. Eljaafari A, Dorval I, Zeliszewski D: Requirements for lysis of activated T cells by class-II-restricted cytolytic T-lymphocytes. Huma Immunol 35:50, 1992.
30. + cell depletion. Cell 54:56, 1989.
31. Mescher MF: Surface contact requirements for activation of cytotoxic T lymphocytes. J Immunol 149:2042, 1992.
32. Schneck J, Maloy WL, Coligan JE, Margulies DH: Inhibition of an allospecific T cell hybridoma by soluble class I proteins and peptides: estimation of the affinity of a T cell receptor for MHC. Cell 56:47, 1989.
33. Wyss-Coray T, Brander C, Bettens F, Mijic D, Pichler WJ: Use of antibody/peptide constructs to direct antigenic peptides to T cells: evidence for T cell processing and presentation. Cell Immunol 139:268, 1992.
34. Hadley GA, Anderson CB, Mohanakumar T: Selective loss of functional antidonor cytolytic T cell precursors following donor-specific blood transfusions in long-term renal allograft recipients. Transplantation 54:333, 1992.
35. Lechler RI, Lombardi G, Batchelor JR, Reinsmoen N, Bach FH: The molecular basis of alloreactivity [review]. Immunol Today 11:83, 1990.
36. Matzinger P, Sevan MJ: Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens? Cell Immunol 29:1, 1977.
37. Liu Z, Sun Y-K, Xi Y-P, Harris P, Suciu-Foca N: T cell recognition of self-human histocompatibility leukocyte antigens (HLA)-DR peptides in context of syngeneic HLA-DR molecules. J Exp Med 175:1663, 1992.
38. + T cells. J Exp Med (in press), 1993.
39. Sloan-Lancaster J, Evavold BD, Allen PM: Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363:156, 1993.
40. Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN: Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515, 1995.