Oxygenation remains unaffected by increased inspiration-to-expiration ratio but impairs hemodynamics in surfactant-depleted piglets

Intensive Care Medicine

Volumn 22, Issue 4, 1996, Pages 329-335

  Lichtwarck Aschoff, M ^a,b   Markstrom A M ^a   Hedlund, A J ^a   Nielsen, J B ^a,c   Nordgren, K A ^a   Sjostrand U H ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b KLINIKUM AUGSBURG   (Germany)

^c HORSENS REGIONAL HOSPITAL   (Denmark)

Author keywords

End inspiratory pressure; Functional residual capacity; Hemodynamics; Intrinsic PEEP; Pressure controlled inverse ratio ventilation

Indexed keywords

ATROPINE; KETAMINE; MORPHINE; PANCURONIUM BROMIDE; PENTOBARBITAL; SURFACTANT; TRACER;

AIRWAY PRESSURE; ANIMAL EXPERIMENT; ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; EXPIRATORY FLOW; FUNCTIONAL RESIDUAL CAPACITY; GAS EXCHANGE; HYDROTHORAX; INSPIRATORY CAPACITY; LUNG HEMODYNAMICS; LUNG LAVAGE; NONHUMAN; OXYGENATION; POSITIVE END EXPIRATORY PRESSURE; SWINE; TIDAL VOLUME;

ANIMALS; FUNCTIONAL RESIDUAL CAPACITY; HEMODYNAMIC PROCESSES; POSITIVE-PRESSURE RESPIRATION, INTRINSIC; PRESSURE; PULMONARY GAS EXCHANGE; RANDOM ALLOCATION; RESPIRATION, ARTIFICIAL; RESPIRATORY MECHANICS; SWINE; TIME FACTORS;

EID: 0029873934     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01700455     Document Type: Article

References (29)

1. Dreyfuss D, Soler P, Basset G, Saumon G (1988) High inflation pressure pulmonary edema. Am Rev Respir Dis 137: 1159-1164
2. Hickling K (1990) Ventilatory management of ARDS: can it affect outcome? Intensive Care Med 16: 219-226
3. Kolobow T, Moretti MP, Fumagalli R, Mascheroni D, Prato P, Chen V, Joris M (1987) Severe impairment in lung function induced by high peak airway pressure during mechanical ventilation: an experimental study. Am Rev Respir Dis 135: 312-315
4. Parker JC, Hernandez LA, Peevy KJ (1993) Mechanisms of ventilator-induced lung injury. Crit Care Med 21: 131-143
5. Reynolds EO (1971) Effect of alterations in mechanical ventilator settings on pulmonary gas exchange in hyaline membrane disease. Arch Dis Child 46: 152-159
6. Lachmann B, Danzmann E, Haendly B, Jonson B (1982) Ventilator settings and gas exchange in respiratory distress syndrome. In: Prakash O (ed) Applied physiology in clinical respiratory care. Nijhoff, Dordrecht, pp 141-176
7. Gattinoni L, Pesenti A, Caspani ML, Pelizzola A, Mascheroni D, Marcolin R, Iapichino G, Langer M, Agostoni A, Kolobow T, Melrose DG, Damia G (1984) The role of static lung compliance in the management of severe ARDS unresponsive to conventional treatment. Intensive Care Med 10: 121-126
8. Cole AGH, Weller SF, Sykes MK (1984) Inverse ratio ventilation compared with PEEP in adult respiratory failure. Intensive Care Med 10: 227-232
9. Tharatt RS, Allen RP, Albertson TE (1988) Pressure controlled inverse ratio ventilation in severe adult respiratory failure. Chest 94: 755-762
10. Gurevitch MJ, Dyke JV, Young ES, Jackson K (1986) Improved oxygenation and lower peak airway pressures in severe adult respiratory distress syndrome: treatment with inverse ratio ventilation. Chest 89: 211-213
11. Lain DC, Di Benedetto R, Morris SL, Van Nguyen A, Saulters R, Causey D (1989) Pressure control inverse ratio ventilation as a method to reduce peak inspiratory pressure and provide adequate ventilation and oxygenation. Chest 95: 1081-1088
12. Abraham E, Yoshihara G (1989) Cardiorespiratory effects of pressure controlled inverse ratio ventilation in severe respiratory failure. Chest 96: 1356-1359
13. Marini JJ, Kelsen SG (1992) Re-targeting ventilalory objectives in adult respiratory distress syndrome: new prospects - persistent questions (editorial). Am Rev Respir Dis 146: 2-3
14. Nielsen JB, Sjöstrand UH, Edgren EL, Lichtwarck-Aschoff M, Svensson BA (1991) An experimental study of different ventilatory modes in piglets in severe respiratory distress induced by surfactant depletion. Intensive Care Med 17: 225-233
15. Lichtwarck-Aschoff M, Nielsen JB, Sjöstrand UH, Edgren EL (1992) An experimental randomized study of five ventilatory modes in a piglet model of severe respiratory distress. Intensive Care Med 18: 339-347
16. Lichtwarck-Aschoff M, Zeravik J, Pfeiffer UJ (1992) Intrathoracic blood volume accurately reflects circulatory volume status in critically ill patients with mechanical ventilation. Intensive Care Med 18: 142-147
17. Lichtwarck-Aschoff M, Leucht S, Kisch HW, Zimmermann G, Blümel G, Pfeiffer UJ (1994) Monitoring of right ventricular function using a conventional slow response thermistor catheter. Intensive Care Med 20: 348-353
18. Lewis FR, Elings VB (1978) Microprocessor determination of lung water using thermal-green dye double indiactor dilution. Surg Forum 29: 182-184
19. Larsson A, Linnarsson D, Jonmarker C, Jonson B, Larsson H, Werner O (1987) Measurement of lung volume by sulfur hexafluoride washout during spontaneous and controlled ventilation: further development of a method. Anesthesiology 67: 543-550
20. Lemaire F, Harf A, Simmoneau G, Matamis D, Rivara D, Atlan G (1981) Echanges gazeuz, courbe statique pression-volume et ventilation en pression positive de fin d'expiration. Etude dans seize cas d'insuffisance respiratoire aigüe de l'adulte. Ann Fr Anesth Reanim 5: 435-441
21. Holzapfel L, Robert D, Perrin F, Blanc PL, Palmier B, Guerin C (1983) Static pressure-volume curves and effect of positive end-expiratory pressure on gas exchange in adult respiratory distress syndrome. Crit Care Med 11(8): 591-597
22. Lachmann B, Robertson B, Vogel J (1980) In vivo lung lavage as an experimental model of respiratory distress syndrome. Acta Anaesthesiol Scand 24: 231-236
23. Sjöstrand UH, Lichtwarck-Aschoff M, Nielsen JB, Markström A, Larsson A, Svensson BA, Wegenius GA, Nordgren KA (1995) Different ventilatory approaches to keep the lung open. Intensive Care Med 21: 310-318
24. Lessard MR, Guérot E, Lorino H, Lemaire F (1994) Effects of pressure-controlled ventilation with different I:E ratios versus volume-controlled ventilation on respiratory mechanics, gas exchange, and hemodynamics in patients with adult respiratory distress syndrome. Anesthesiology 80: 983-991
25. Mercat A, Graïni L, Teboul JL, Lenique F, Richard C (1993) Cardiorespiratory effects of pressure-controlled ventilation with and without inverse ratio ventilation in the adult respiratory distress syndrome. Chest 104: 871-875
26. Sydow M, Buchardi H, Ephraim E, Zielmann S, Crozier TA (1994) Long-term effects of two different ventilatory modes on oxygenation in acute lung injury. Comparison of airway pressure release ventilation and volume-controlled inverse ratio ventilation. Am J Respir Crit Care Med 149: 1550-1556
27. Sykes MK, Lumley J (1969) The effect of varying inspiratory: expiratory ratios on gas exchange during anesthesia for open-heart surgery. Br J Anaesth 41: 374-380
28. Perez-Chada RD, Gardaz J-P, Madgwick RG, Sykes MK (1983) Cardiorespiratory effects of an inspiratory hold and continuous positive pressure ventilation in goats. Intensive Care Med 9: 263-269
29. Berman LS, Downs JB, Van Eeden A, Delhagen D (1981) Inspiration: expiration ratio. Is mean airway pressure the difference? Crit Care Med 9: 775-777