Oral contraceptives enhance the risk of clinical manifestation of venous thrombosis at a young age in females homozygous for factor V Leiden

British Journal of Haematology

Volumn 93, Issue 2, 1996, Pages 487-490

  Rintelen, Claudia ^a   Mannhalter, Christine ^a   Ireland, Helen ^b   Lane, David A ^b   Knöbl, Paul ^a   Lechner, Klaus ^a   Pabinger, Ingrid ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

APC resistance; Factor V Leiden; Oral contraceptives; Thrombophilia; Venous thromboembolism

Indexed keywords

BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5 LEIDEN; ORAL CONTRACEPTIVE AGENT;

ADULT; AGE; AGED; ARTICLE; CLINICAL ARTICLE; DEEP VEIN THROMBOSIS; FEMALE; HOMOZYGOTE; HUMAN; MALE; PRIORITY JOURNAL; SEX DIFFERENCE;

AUSTRIA; BIOLOGY; CONTRACEPTION; CONTRACEPTIVE METHODS; DEVELOPED COUNTRIES; DISEASES; EMBOLISM; ENDOCRINE SYSTEM; ESTROGENS; EUROPE; EXAMINATIONS AND DIAGNOSES; FAMILY PLANNING; GENETICS; HORMONE REPLACEMENT THERAPY; HORMONES; ORAL CONTRACEPTIVES; ORAL CONTRACEPTIVES, COMBINED; PHYSIOLOGY; RESEARCH REPORT; RISK FACTORS; SCREENING; THROMBOEMBOLISM; THROMBOSIS; TREATMENT; VASCULAR DISEASES; WESTERN EUROPE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CONTRACEPTIVES, ORAL; FACTOR V; FEMALE; HOMOZYGOTE; HUMANS; MALE; MIDDLE AGED; MUTATION; PROTEIN C; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOEMBOLISM; THROMBOPHLEBITIS;

EID: 0029873789     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.5712013.x     Document Type: Article

References (11)

1. Bertina, R.M., Koeleman, B.P.C., Koster, T., Rosendaal, F.R., Dirven, R.J., de Ronde, H., van der Velden, P.A. & Reitsma, P.H. (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature, 369, 64-67.
2. Bloemenkamp, K.W., Rosendaal, F.R., Heimerhorst, F.M., Büller, H.R. & Vandenbroucke, J.P. (1995) Financement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestagen. Lancet, 346, 1595-1596.
3. Dahlbäck, B., Carlsson, M. & Svensson, P.J. (1995) Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proceedings of the National Academy of Sciences of the United States of America, 90, 1004-1008.
4. Greengard, J.S., Eichinger, S., Griffin, J.H. & Bauer, K.A. (1994) Variability of thrombosis among homozygous siblings with resistance to activated protein C due to an ArgGln mutation in the gene for factor V. New England Journal of Medicine, 31, 1559-1562.
5. Hopmeier, P. & Krugluger, W. (1995) Factor V Leiden and thrombophilia. New England Journal of Medicine, 332, 1381-1382.
6. Pabinger, I. & Schneider, B., and the GTH Study Group on Natural Inhibitors (1994) Thrombotic risk of women with hereditary antithrombin III-, protein C- and protein S-deliciency taking oral contraceptive medication. Thrombosis and Haemostasis, 71, 548-552.
7. Ridker, P.M., Hennekens, C.H., Lindpaintner, K., Stampfer, M.J., Eisenberg, P.R. & Miletich, J.P. (1995) Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thromboembolism in apparently healthy men. New England Journal of Medicine, 332, 912-917.
8. Rosendaal, F.R., Koster, T., Vandenbrouke, J.P. & Reitsma, P.H. (1995) High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood, 85, 1504-1508.
9. Tait, R.C., Isobel, D. Walker, Perry, D.J., Islam, SIAM, Daly, M.E., McCall, F., Conkie, J.A. & Carrell, R. (1994) Prevalence of antithrombin deficiency in the healthy population. British Journal of Haematology, 87, 106-112.
10. Vandenbroucke, J.P., Koster, T., Briet, E., Reitsma, P.H., Bertina, R.M. & Rosendaal, F.R. (1994) Increases risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet, 344, 1453-1457
11. Voorberg, J., Roelse, J., Koopman, R., Büller, H., Berends, F., Cate, J.W., Mertens, K. & van Mourik, J.A. (1994) Association of idiopathic venous thromboembolism with single point mutation at Arg 506 of factor V. Lancet, 343, 1535-1536.