Mutation of the thymidine kinase gene in a ganciclovir-resistant strain of herpes simplex virus type 1 (HSV-1) detected by PCR-SSCP and PCR-direct sequencing

Biomedical Research

Volumn 17, Issue 1, 1996, Pages 9-14

  Shiota, Hiroshi ^a   Kudo, Eiji ^a   Mimura, Yasuo ^a   Itakura, Mitsuo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; METHIONINE; THYMIDINE KINASE;

ARTICLE; CODON; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE MUTATION; HERPES; HERPES SIMPLEX VIRUS 1; IMMUNE DEFICIENCY; NONHUMAN; POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; TEMPERATURE DEPENDENCE;

EID: 0029873768     PISSN: 03886107     EISSN: None     Source Type: Journal    
DOI: 10.2220/biomedres.17.9     Document Type: Article

References (17)

1. COEN D. M. (1990) Antiviral drug resistance. Ann. N. Y. Acad. Sci. 616, 224-237
2. COLLINS P. (1993) Mechanisms of herpes virus resistance. Ann. Med. 25, 441-445
3. COREY L. and SPEAR P. G. (1986) Infections with herpes simplex viruses. N. Engl. J. Med. 314, 749-757
4. FOLKERS G., TRUMPP-KALLMEYER S., GUTBROD O., KRICKL S., FETZER J. and KEIL G. M. (1991) Computer-aided active-site-directed modeling of the herpes simplex virus 1 and human thymidine kinase. J. Comput. Aided Mol. Des. 5, 385-404
5. HWANG C. B. C., HORSBURGH B., PELOSI E., ROBERTS S., DIGARD P. and COEN D. M. (1994) A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant. Proc. Natl. Acad. Sci. USA 91, 5461-5465
6. IRMIERE A. F., MANOS M. M., JACOBSON J. G., GIBBS J. S. and COEN D. M. (1989) Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability. Virology 168, 210-220
7. KEATING M. R. (1992) Antiviral agents. Mayo Clin. Proc. 67, 160-178
8. KIT S., KIT M., QAVI H., TRKULA D. and OTSUKA H. (1983) Nucleotide sequence of the herpes simplex virus type 2 (HSV-2) thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide and its comparison with the HSV-1 thymidine kinase gene. Biochem. Biophys. Acta 741, 158-170
9. MCGEOCH D. J., DALRYMPLE M. A., DAVIDSON A. J., DOLAN A., FRAME M. C., MCNAB D., PERRY L. J., SCOTT J. E. and TAYLOR P. (1988) The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69, 1531-1574
10. MCKNIGHT S. L. (1980) The nucleotide sequence and transcript map of the herpes simplex thymidine kinase gene. Nucleic Acids Res. 8, 5949-5964
11. ORITA M., SUZUKI Y., SEKIYA T. and RAYASHI K. (1989) Rapid and sensitive detection of point mutations and DNA polymorphism using the polymerase chain reaction. Genomics 5, 874-879
12. PALÙ G. and BIASOLO M.-A. (1988) Nucleotide sequence of the thymidine kinase gene of a new strain of herpes simplex virus type 1. Virus Genes 2, 183-186
13. ROGERS B. B., JOSEPHSON S. L. and MAK S. K. (1991) Detection of herpes simplex virus using the polymerase chain reaction followed by endonuclease cleavage. Amer. J. Pathol. 139, 1-6
14. SHIOTA H. (1989) Symposium (I)-3: herpetic keratitis - problems of the treatment and their solutions. Nippon Ganka Gakkai Zasshi (Acta Soc. Ophthalmol. Jap.) 93, Suppl. 90 (in Japanese)
15. SHIOTA H., NAITO T. and MIMURA Y. (1987) Anti-herpes simplex virus (HSV) effect of 9-(1,3-dihydroxy-2-propoxy-methyl)guanine (DHPG) in rabbit cornea. Curr. Eye Res. 6, 241-245
16. SUMMERS W. P., WANGER M. and SUMMERS W. C. (1975) Possible peptide chain termination mutants in thymidine kinase gene of a mammalian virus, herpes simplex virus. Proc. Natl. Acad. Sci. USA 72, 4081-4084
17. WILBER B. A. J. and DOCHERTY J. J. (1994) Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2′-deoxyuridine. J. Gen. Virol. 75, 1743-1747