Infertility and impotence following renal transplantation

Current Opinion in Urology

Volumn 6, Issue 2, 1996, Pages 115-119

  Gritsch, H Albin ^a   Vivas, Carlos ^a   Jordan, Mark L ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

ALLOGRAFT; CHRONIC KIDNEY FAILURE; ENDOCRINE FUNCTION; FEMALE; HUMAN; IMPOTENCE; INFERTILITY; KIDNEY DISEASE; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; REPRODUCTION; SHORT SURVEY;

EID: 0029873359     PISSN: 09630643     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042307-199603000-00013     Document Type: Short Survey

References (27)

1. Reinberg Y, Bumgardner GL, Aliabadi H: Urological aspects of renal transplantation. J Urol 1990, 143:1087-1092.
2. Dillard FT, Miller BS, Sommer BG, Horchak AM, York YP, Nesbitt JA: Erectile dysfunction posttransplant. Transplant Proc 1989, 21:3961-3962.
3. Kaufman JM, Hatzichristou DG, Mulhall JP, Fitch WP, Goldstein I: Impotence and chronic renal failure: a study of the hemodynamic pathophysiology. J Urol 1994, 151:612-618. A retrospective multi-institutional study of vascular disease in patients with ESRD. Cavernous artery occlusive disease was found in 78% of the patients and 90% of patients had corporeal veno-occlusive dysfunction. Renal failure-associated vascular disease of the penis occurred independently of known atherosclerosis risk factors. The most likely pathophysiology of renal failure-associated vascular disease appears to involve hypoxic changes of the contractile (smooth muscle) and structural (collagen/elastin) components of the erectile tissue.
4. Lim VS: Reproductive function in patients with renal insufficiency. Am J Kidney Dis 1987, 9:363-367.
5. Foulks CJ, Cushner HM: Sexual dysfunction in the male dialysis patient: pathogenesis, evaluation, and therapy. Am J Kidney Dis 1986, 8:211-222.
6. Killion D, Rajfer J: The evaluation and management of male infertility following solid-organ transplantation. Semin Urol 1994, 12:140-146. This manuscript reviews and discusses the animal studies which have demonstrated a central/hypothalamic and peripheral/testicular testosterone synthesis defect with cyclosporin administration.
7. Holdsworth SR, Dekretser DM, Atkins RC: A comparison of hemodialysis and transplantation in reversing the uremic disturbance of male reproductive function. Clin Neph 1978, 10:146-150.
8. Davison JM: Pregnancy in renal allograft recipients: problems, prognosis and practicalities. Baillieres Clin Obstet Gynaecol 1994, 8:501-525. A current review of the literature and prevailing controversies regarding pregnancy in renal transplant recipients. The risks to the mother and fetus in over 5000 pregnancies in renal transplant recipients are summarized. Specific management of allograft dysfunction, infections, and obstetrical emergencies is discussed.
9. Penn I, Makowski E, Harris P: Parenthood following renal and hepatic transplantation. Transplantation 1980, 30:397-400.
10. Mancini R, Lavieri J, Muller F, Andrada J, Saraceni D: Effect of prednisolone upon normal and pathologic human spermatogenesis. Fertil Steril 1966, 17:500-513.
11. Physicians' Desk Reference. 49th edn. Montvale, NJ: Medical Economics Company; 1995.
12. Seethalakshmi L, Flores C, Malhotra RK, Pallias JD, Tharakan D, Khauli RB, Menon M: The mechanism of cyclosporine's action in the inhibition of testosterone biosynthesis by rat Leydig cells in vitro. Transplantation 1992, 53:190-195.
13. Rajfer J, Sikka S, Lemmi C, Koyle MA: Cyclosporine inhibits testosterone biosynthesis in the rat testis. Endocrinology 1987, 121:586-589.
14. Wilner ML, Ettenger RB, Koyle MA, Rosenthal JT: The effect of hypoprolactinemia alone and in combination with cyclosporine on allograft rejection. Transplantation 1990, 49:264-267.
15. Abuzeid MI, Basata S, Chan YM, Beer M, Sasy MA: Fertilization and pregnancy achieved by intracytoplasmic injection of sperm retrieved from testicular biopsies. Fertil Steril 1995, 64:644-646.
16. Witt MA, Elsner C, Kort HI, Massey JB, Mitchell-Leef D, Toledo AA, Tucker MJ: A live birth from intracytoplasmic injection of a spermatozoon retrieved from testicular parenchyma. J Urol 1995, 154:1136-1137.
17. Bourne H, Watkins W, Speirs A, Baker HWG: Pregnancies after intracytoplasmic injection of sperm collected by fine needle biopsy of the testis. Fertil Steril 1995, 64:433-436.
18. Yemini M, Vanderzwalmen P, Mukaida T, Schoengold S, Birkenfeld A: Intracytoplasmic sperm injection, fertilization, and embryo transfer after retrieval of spermatozoa by testicular biopsy from an azoospermic male with testicular tubular atrophy. Fertil Steril 1995, 63:1118-1120.
19. Barry JM: The evaluation and treatment of erectile dysfunction following organ transplantation. Semin Urol 1994, 12:147-153.
20. Breza J, Reznicek J, Pribylincova V, Zvara P: Erectile dysfunction in patients treated with hemodialysis and kidney transplantation. Bratisl Lek Listy 1993, 94:489-493.
21. Fallon B: Intracavernous injection therapy for male erectile dysfunction. Urol Clin North Am 1995, 22:833-845.
22. Zonszein J: Diagnosis and management of endocrine disorders of erectile dysfunction. Urol Clin North Am 1995, 22:789-802.
23. Berkow R, Fletcher AJ: The Merck Manual, 16th edn. Rathway, NJ: Merck Research Laboratories; 1992.
24. 1 in the treatment of sexual impotence after heart transplantation: initial clinical experience. J Heart Lung Transplant 1993, 12:484-486.
25. Rodriguez AA, Morales AM, Andres A, Fernandez AT, Diaz GR, Pamplona M, Alvarez E: Treatment of erectile impotence in renal transplant patients with intracavernosal vasoactive drugs. Transplant Proc 1992, 24:105-106.
26. Hill CC, Jordan ML, Bahnson RR: Penile prosthesis surgery in the immunosuppressed patient Transplantation 1993, 56:1020-1021.
27. Brinster RL, Zimmermann JW: Spermatogenesis following male germ-cell transplantation. Proc Natl Acad Sci USA 1994, 91:11298-11302. The first description of germ-cell transplantation in mice. This technique may be instrumental in further investigations of spermatogenic arrest and potential germ-line gene therapy.