A novel antitumor compound, NC-190, induces topoisomerase II-dependent DNA cleavage and DNA fragmentation

Cancer Chemotherapy and Pharmacology

Volumn 38, Issue 1, 1996, Pages 29-34

  Yamagishi, Takehiro ^a   Nakaike, Shiro ^a   Ikeda, Tomotake ^a   Ikeya, Hisao ^a   Otomo, Susumu ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Apoptosis; Cleavable complex; DNA intercalation; NC 190; Topoisomerase II

Indexed keywords

6 [[2 (DIMETHYLAMINO)ETHYL]CARBAMOYL] 5 HYDROXY 10 METHOXYBENZO[A]PHENAZINE 9 CARBOXYLIC ACID; ANTINEOPLASTIC AGENT; BENZO[A]PHENAZINE DERIVATIVE; CAMPTOTHECIN; DNA FRAGMENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ETHIDIUM BROMIDE; ETOPOSIDE; INTERCALATING AGENT; NEW DRUG; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CLEAVAGE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME PURIFICATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; DNA; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; HL-60 CELLS; HUMANS; PEPTIDE FRAGMENTS; PHENAZINES; TRYPAN BLUE; TUMOR CELLS, CULTURED;

EID: 0029873310     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050443     Document Type: Article

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