The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 8, 1996, Pages 923-928

  De Laszlo, Stephen E ^a   Glinka, Tomasz W ^a   Greenlee, William J ^a   Ball, Richard ^a   Nachbar, Robert B ^a   Prendergast, Kristine ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN ANTAGONIST; BIPHENYL DERIVATIVE; MACROCYCLIC COMPOUND; QUINAZOLINE DERIVATIVE;

ANIMAL TISSUE; AORTA; ARTICLE; BINDING AFFINITY; BRAIN; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RABBIT; RAT; X RAY ANALYSIS;

EID: 0029873109     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00116-3     Document Type: Article

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20. -3 and this peak is without chemical significance. The atomic coordinates for this structure have been deposited with the Cambridge Crystallographic Data Centre. The coordinates can be obtained on request from the Director, Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK.
21. -3 and this peak is without chemical significance. The atomic coordinates for this structure have been deposited with the Cambridge Crystallographic Data Centre. The coordinates can be obtained on request from the Director, Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK.
22. 2 potencies are mean values of the results of several independent measurements in fresh preparations of membrane fraction, each run in triplicate.
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