Synthesis and activity of conformationally-constrained macrocyclic norstatine-based inhibitors of HIV protease

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 4, 1996, Pages 435-438

  Chen, Jian Jeffrey ^a,g   Coles, Peter J ^b,g   Arnold, Lee D ^c,g   Smith, Roger A ^d,g   MacDonald, I David ^e,g   Carrière, Julie ^g   Krantz, Allen ^f,g  

^a ROCHE BIOSCIENCE   (United States)

^b GLAXOSMITHKLINE   (Canada)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d BAYER CORPORATION   (United States)

^e Hemosol Inc   (Canada)

^f Red Cell Inc   (United States)

^g BioSci Research Canada Ltd   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; MACROCYCLIC COMPOUND; PROTEINASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 0029872870     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00034-0     Document Type: Article

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18. 3) includes 4.2 ppm (m, CH(OH)CO). Abbreviations: Bn = benzyl; NMM = N-methyl-morpholine; EDC = N-ethyl-N′-dimethylaminopropylcarbodiimide hydrochloride; HOBt = 1-hydroxybenzotriazole.