A pilot study of clostridium collagenase (Collagenase ABC®) ointment in the debridement of dermal ulcers

Clinical Drug Investigation

Volumn 11, Issue 3, 1996, Pages 139-144

  Harding, K G ^a   Bale, S ^a   Llewellyn, M ^a   Baggott, J ^a   Robbins, K ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b Advisory Services Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLOSTRIDIOPEPTIDASE A; COLLAGENASE; WHITE PETROLATUM;

ADULT; ADVERSE DRUG REACTION; AGED; ARTICLE; BLOOD CELL COUNT; BLOOD CHEMISTRY; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; DEBRIDEMENT; DECUBITUS; DRUG EFFICACY; DRUG SAFETY; DRUG THERAPY; FEMALE; HUMAN; INFLAMMATION; LABORATORY TEST; MALE; NURSING STAFF; OINTMENT; PAIN; PATIENT MONITORING; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PUS; SKIN NECROSIS; SKIN ULCER; TOPICAL DRUG ADMINISTRATION; ULCER HEALING;

EID: 0029872688     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-199611030-00003     Document Type: Article

References (11)

1. Winfer GD. Formation of the scab and rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature 1962; 193: 293-4
2. Varma AO, Bugatch E, German FM. Debridement of dermal ulcers with collagenase. Surg Gynecol Obstet 1973; 136: 281-2
3. Howes EL, Mandl I, Zaffuto S, et al. The use of Clostridium histolyticum enzymes in the treatment of experimental third degree burns. Surg Gynecol Obstet 1959; 109: 177-88
4. Sherry S, Fletcher AP. Proteolytic enzymes: a therapeutic evaluation. Clin Pharmacol Ther 1960; 1: 202
5. Boxer AM, Gottesman N, Bernstein H, et al. Debridement of dermal ulcers and decuhiti with collagenase. Geriatrics 1969; 24: 75-86
6. Lee LK, Ambrus JL. Collagenase therapy for decubitus ulcers. Geriatrics 1975; 30: 91-8
7. Bardfield LA. In: Mandl I, editor. Collagenase. New York: Gordon & Breach, 1972: 191-5
8. German FM. In: Mandl I, editor. Collagenase. New York: Gordon & Breach, 1972: 165-9
9. Helaly P, Vogt E, Schneider G. Wound healing disorders and their enzymatic therapy - a multicentre double-blind study. Schweiz Rundsch Med Prax 1988; 77 (52): 1428-34
10. Karch FE, Lasagna L. Adverse drug reactions. A critical review. JAMA 1975; 234: 1236-41
11. Lee LK, Ambrus JL. Collagenase therapy for decubitus ulcers. Geriatrics 1975; 30: 91-8