The brain of the asphyxiated fetus - Basic research

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 65, Issue 1, 1996, Pages 19-24

  Jensen, Arne ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Asphyxia; Fetal brain; Fetal circulation; Hypoxaemia

Indexed keywords

ASPHYXIA; BRAIN BLOOD FLOW; CONFERENCE PAPER; FETUS; FETUS CIRCULATION; FETUS DEVELOPMENT; HUMAN; HYPOXEMIA; PRIORITY JOURNAL;

EID: 0029872132     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-2243(95)02297-6     Document Type: Conference Paper

References (57)

1. Campbell AGM, Dawes GS, Fishman AP, Hyman AI. Regional redistribution of blood flow in the mature fetal lamb. Circ Res 1967; 21: 229-235.
2. Cohn HE, Sacks EJ, Heymann MA, Rudolph AM. Cardiovascular responses to hypoxemia and acidemia in fetal lambs. Am J Obstet Gynecol 1974; 120: 817-824.
3. Peeters LLH, Sheldon RE, Jones, JR, MD, Makowski EL, Meschia G. Blood flow to fetal organs as a function of arterial oxygen content. Am J Obstet Gynecol 1979; 135: 637-646.
4. Ashwal S, Majcher JS, Longo LD. Patterns of fetal lamb regional cerebral blood flow during and after prolonged hypoxia: Studies during the posthypoxic recovery period. Am J Obstet Gynecol 1981; 139: 365-372.
5. Berger R, Jensen A. Fetal circulatory responses to oxygen lack. J Dev Physiol 1991; 16: 181-207
6. Rudolph AM, Heymann MA. Circulatory changes during growth in the fetal lamb. Circ Res 1970; 26: 289-299.
7. Walker AM, Cannata JP, Dowling MH, Ritchie BC, Maloney JE. Sympathetic and parasympathetic control of heart rate in unanesthetized fetal and newborn lambs. Biol Neonate 1078; 33: 135-143.
8. Walker AM, Cannata JP, Dowling MH, Ritchie BC, Maloney JE. Age-dependent pattern of autonomic heart rate control during hypoxia in fetal and newborn lambs. Biol Neonate 1979; 35: 198-208.
9. Iwamoto HS, Kaufman T, Keil LC, Rudolph AM. Responses to acute hypoxemia in the fetal sheep at 0.6-0.7 gestation. Am J Physiol 1989; 256: H613-H620.
10. Iwamoto HS. Cardiovascular resonses to reduced oxygen delivery: studies in fetal sheep at 0.55-0.7 gestation. In: Gluckman PD, Johnston BM, Nathanielsz PW, eds. Advances in Fetal Physiology: Reviews in Honor of G.C. Liggins. Ithaca, New York: Perinatology Press, 1989b; 43-54.
11. Rudolph AM, Heymann MA. Circulation of the fetus in utero: methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 1967; 21: 163-184.
12. Jensen A. The role of the sympathetic nervous system in preventing perinatal brain damage. In: Künzel W, eds. Oxygen, Basis of the Regulation of Vital Functions in the Fetus. Berlin, New York: Springer Verlag, Heidelberg, 1991; 77-107.
13. Jensen A, Roman C, Rudolph AM. Effects of reducing uterine blood flow on fetal blood flow distribution and oxygen delivery. J Dev Physiol 1991; 15: 309-323.
14. Carter AM, Gu W. Cerebral blood flow in the fetal guinea-pig. J Dev Physiol 1988; 10: 123-129.
15. 2 delivery. Am J Physiol 1987; 252: H100-H109.
16. Jensen A, Hohmann M, Künzel W. Dynamic changes in organ blood flow and oxygen consumption during acute asphyxia in fetal sheep. J Dev Physiol 1987b; 9: 543-559.
17. Jensen A, Künzel W, Hohmann M. Dynamics of fetal organ blood flow redistribution and catecholamine release during acute asphyxia. In: Jones CT, Nathanielsz PW, eds. The Physiological Development of the Fetus and Newborn. London and Orlando: Academic Press, 1985b; 405-410.
18. Dawes GS. Foetal and Neonatal Physiology. Chicago: Year Book Medical Publishers, 1968.
19. Jones CT, Boddy K, Robinson JS, Ratcliffe JG. Developmental changes in the responses of the adrenal glands of the foetal sheep to endogenous adrenocorticotrophin as indicated by hormone responses to hypoxaemia. J Endocrinol 1977; 72: 279-292.
20. Richardson BS, Rurak D, Patrick JE, Homan J, Carmichael L. Cerebral oxidative metabolism during sustained hypexemia in fetal sheep. J Dev Physiol 1989; 11: 37-43.
21. Block BS, Schlafer DH, Wentworth RA, Kreitzer LA, Nathanielsz PW. Regional blood flow distribution in fetal sheep with intrauterine growth retardation produced by decreased umbilical placental perfusion. J Dev Physiol 1990; 13: 81-85.
22. Johnson GN, Palahniuk RJ, Tweed WA, Jones MV, Wade JG. Regional cerebral blood flow changes during severe fetal asphyxia produced by slow partial umbilical cord compression. Am J Obstet Gynecol 1979; 135: 48-52.
23. Purves MJ, James IM. Observations on the control of cerebral blood flow in the sheep fetus and newborn lamb. Circ Res 1969; 25: 651-667.
24. Lou HC, Lassen NA, Tweed WA, Johnson G, Jones M, Palahniuk RJ. Pressure passive cerebral blood flow and breakdown of the blood-brain barrier in experimental asphyxia. Acta Paediatr Scand 1979; 68: 57-63.
25. Tweed WA, Cote J, Pash M, Lou H. Arterial oxygenation determines autoregulation of cerebral blood flow in the fetal lamb. Pedriatr Res 1983; 17: 246-249.
26. Papile L-A, Rudolph AM, Heymann MA. Autoregulation of cerebral blood flow in the preterm fetal lamb. Pediatr Res 1985; 19(2): 159-161.
27. Clapp III, JF, Peress NS, Wesley M, Mann LI. Brain damage after intermittant partial cord occlusion in the chronically instrumented fetal lamb. Am J Obstet Gynecol 1988; 159: 504-509.
28. Chao CR, Hohimer AR, Bissonette JM. Cerebral carbohydrate metabolism during severe ischemia in fetal sheep. J Cereb Blood Flow Metab 1989; 9: 53-57.
29. Berger R, Gjedde A, Heck J, Müller E, Krieglstein J, Jensen A. Extension of the 2-deoxyglucose method to the fetus in utero: theory and normal values for the cerebral glucose consumption in fetal guinea pigs. J Neurochem 1994; 63: 271-279
30. Makowski EL, Schneider JM, Tsoulos NG, Colwill JR, Battaglia FC, Meschia G. Cerebral Blood Flow, oxygen consumption and glucose utilization of fetal lambs in utero. Am J Obstet Gynaecol 1972; 114: 292-303.
31. Richardson BS, Hohimer AR, Bissonette JM, Machida CM. Cerebral metabolism in hypoglycemic and hyperglycemic fetal lambs. Am J Physiol (Regulatory, Integrative and Comparative Physiology 14) 1983; R730-R736.
32. Myers RE. Experimental models of perinatal brain damage: Relevance to human pathology. In: Gluck L, ed. Intrauterine Asphyxia and the Developing Fetal Brain. New York: Year Book Publ. Co., 1977; 37-97.
33. Myers RE. Lactic acid accumulation as cause of brain edema and cerebral necrosis resulting from oxygen deprivation. In: Korobkin R, Guilleminault C, eds. Advances in Perinatal Neurology. Spectrum Publ., New York, 1979; 85-114.
34. Wagner KR, Ting P, Westfall MV, Yamaguchi S, Bacher JD, Myers RE. Brain metabolic correlates of hypoxia-ischemic cerebral necrosis in mid gestational sheep fetuses: significance of hypotension. J Cereb Blood Flow Metab 1986; 6: 425-434.
35. Berger R, Jensen A, Krieglstein J, Steiglmann JP. Effects of acute asphyxia on brain energy metabolism in fetal guinea pigs near term. J Dev Physiol 1991a; 16: 9-11.
36. Berger R, Jensen A, Krieglstein J, Steiglmann JP. Cerebral energy metabolism in fetal guinea pig fetuses during development. J Dev Physiol 1991b; 16: 317-319.
37. Siesjö BK. Brain Energy Metabolism. Chichester-New York-Brisbane-Toronto: Wiley and Sons, 1978.
38. Siesjö BK, Bengtsson F. Calcium, calcium antagonists, and ischemic cell death in the brain. In: Krieglstein J, eds. Pharmacology of Cererbal Ischemia. Wissenschaftliche Verlagsgesellschaft Stuttgart, 1988; 23-29.
39. Dawes GS, Fox HE, Leduc BM, Liggins GC, Richards RT. Respiratory movements and rapid-eye-movement sleep in the foetal lamb. J Physiol 1972; 220: 119-143.
40. Jensen A, Bamford OS, Dawes GS, Hofmeyr G, Parkes MJ. Changes in organ blood flow between high and low voltage electrocortical activity in fetal sheep. J Dev Physiol 1986; 8: 187-194.
41. Reid DL, Jensen A, Phernetton TM, Rankin JHG. Relationship between plasma catecholamine levels and electrocortical state in the mature fetal lamb. J Dev Physiol 1990; 13: 75-79.
42. Walker AM, de Preu ND, Home RSC, Berger PJ. Anatomic control of heart rate differs with electrocortical activity and chronic hypoxaemia in fetal lambs. Biol Neonate 1990; 14: 43-48.
43. Martin CB, Voersmans TMG, Jongsma HW. Effect of reducing uteroplacental blood flow on movements and on electrocortical activity of fetal sheep. Gynecol Obstet Invest 1987a; 23: 3439.
44. Mann LI, Prichard JW, Symmes D. EEG, ECG, and acid-base observations during acute fetal hypoxia. Am J Obstet Gynecol 1970; 106: 39-51.
45. Dawes GS. Breathing and rapid-eye-movement sleep before birth. In: Foetal and Neonatal Physiology, Proceedings of the Sir Joseph Barcroft Centenary Symposium. Cambridge, University Press, 1973; 49-62.
46. Boddy K, Dawes GS, Fisher R, Pinter S, Robinson JS. Foetal respiratory movements, electrocortical and cardiovascular responses to hypoxaemia and hypercapnia in sheep. J Physiol 1974a; 243: 599-618.
47. Nathanielz PW, Bailey A, Poore ER, Thorburn GD, Harding R. The relationship between myometrial activity and sleep state and breathing in fetal sheep throughout the last third of gestation. Am J Obstet Gynecol 1980; 138: 653-659.
48. Booking AD, Harding R. Effects of reduced uterine blood flow on electrocortical activity, breathing, and skeletal muscle activity in fetal sheep. Am J Obstet Gynecol 1986a; 154: 655-662.
49. Harding R, Poore ER, Cohen GL. The effect of brief episodes of diminished uterine blood flow on breathing movements, sleep states and heart rate in fetal sheep. J Dev Physiol 1981; 3: 231-243.
50. Maloney JE, Adamson TM, Brodecky V, Dowling MH, Ritchie BC. Modification of respiratory centre output in the unanesthetized fetal sheep 'in utero'. J Appl Physiol 1975; 39: 552-558.
51. Dawes GS, Gardner WN, Johnston BM, Walker DW. Breathing in fetal lambs: the effect of brain stem section. J Physiol 1983; 335: 535-553.
52. Blanco CE, Dawes GS, Walker DW. Effect of hypoxia on polysynaptic hindlimb reflexes of unanesthetized fetal and newborn lambs. J Physiol 1983; 339: 453-466.
53. Koos BJ, Kitanaka T, Matsuda K, Gilbert RD, Longo LD. Fetal breathing adaption to prolonged hypoxaemia in sheep. J Dev Physiol 1988; 10: 161-166.
54. Bissonette JM, Hohimer AR, Willeke GB. Effect of asphyxia on respiratory activity in fetal sheep. J Dev Physiol 1989; 12: 157-161.
55. Berger R, Karcher J, Lehmann T, Jensen A. Neuroprotektion des Feten im Sauerstoffmangel. Arch Gynecol Obstet 1994; 255(Suppl 1): S.121-S.122
56. Jensen A, Berger R, Schachenmayr, Lehmann T, Karcher J. Der Hirnschaden des Feten im Sauerstoffmangel -Neue Wege der Protektion. Arch Gynecol Obstet 1994; 255(Suppl 1): S.121
57. Garnier Y, Klossek H, Jensen A. Flunarizin, ein neuroprotektiver Kalziumantagonist, hat keinen Einfluß auf die fetale Kreislaufzentralisation bei Asphyxie. Arch Gynecol Obstet 1994; 255(Suppl 1): S.122-S.123