Use of recombinant factor vila (novoseven®) in the treatment of two patients with type iii von willebrand’s disease and an inhibitor against von willebrand factor

Pathophysiology of Haemostasis and Thrombosis

Volumn 26, Issue , 1996, Pages 150-154

  Ciavarell, N ^a   Schiavoni, M ^a   Valenzano, E ^a   Mangini, F ^b   Inchingolo, F ^b  

^a Centro Emofilia   (Italy)

^b POLICLINICO   (Italy)

Author keywords

Inhibitor; Oral surgery; Recombinant factor VIla; Treatment; Von Willebrand s disease

Indexed keywords

ANTIBIOTIC AGENT; ANTIFIBRINOLYTIC AGENT; BLOOD CLOTTING FACTOR INHIBITOR; RECOMBINANT BLOOD CLOTTING FACTOR 7A; TRANEXAMIC ACID; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ADOLESCENT; ADULT; BLEEDING; CASE REPORT; CONFERENCE PAPER; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; ORAL SURGERY; PRIORITY JOURNAL; VON WILLEBRAND DISEASE;

ADOLESCENT; ADULT; FACTOR VIIA; HUMANS; ISOANTIBODIES; MALE; POSTOPERATIVE HEMORRHAGE; RECOMBINANT PROTEINS; SURGERY, ORAL; VON WILLEBRAND DISEASE;

EID: 0029872095     PISSN: 14248832     EISSN: 14248840     Source Type: Journal    
DOI: 10.1159/000217258     Document Type: Article

References (7)

1. Ruggeri ZM, Ciavarella N, Mannuc-ci PM, Molinari A, Dammacco F, Lavergne JM, Meyer D: Familial incidence of precipitating antibodies in von Willebrand disease: A study of four cases. J Lab Clin Med 1979; 94:60-75.
2. Bergamaschini L, Ciavarella N, Fe-derici A, Di Rocco N, Schiavoni M, Stefanile C, Mannucci PM: Post-transfusional non-IgE-mediat-ed anaphylaxis in two patients with von Willebrand disease type III with inhibitor: The role of IgG subclasses (abstract 1023). Thromb Haemost 1995;73:1167.
3. Ngo K.Y. Trifard-Glotz V. Kloziol JA. Lynch DC, Gitschier J, Ranieri P. Ciavarella N, Ruggeri ZM, Zim-mermann TS: Homozygous and heterozygous deletion of the von Willebrand factor gene in patients and carriers of severe von Willebrand disease. Proc Natl Acad Sci USA 1988;85:2753-2754.
4. Bergamaschini L, Mannucci PM, Federici AB, Coppola R, Guzzoni S, Agostoni A: Posttransfusion anaphylactic reactions in a patient with severe von Willebrand disease: Role of complement and alloantibodies to von Willebrand factor. J Lab Clin Med 1995;126:348-356.
5. Majumdar G, Phillips JK. Lavallec H, Savidge GF: Acquired hemophilia in association with type III von Willebrand's disease: Successful treatment with high purity on Willc-brand’s factor and recombinant factor Vila. Blood Coagul Fibrinolysis 1993;4:1035-1037.
6. Ruggeri ZM, Mannucci PM, Jeff-coate SL, Ingram GIC: Immunora-diomctric assay of factor VIII related antigen with observations in 32 patients with von Willebrand’s disease. Br J Haematol 1976;33:221-231.
7. Soff GA, Green D: Autoantibody to von Willebrand factor in systemic lupus erythematosus. J Lab Clin Med 1993;121:424-430.