Enzyme-linked immunosorbent assay of pravastatin, a HMG-CoA reductase inhibitor, in human plasma

Journal of Immunoassay

Volumn 17, Issue 1, 1996, Pages 13-27

  Muramatsu, Shigeki ^a   Takasaki, Wataru ^a   Uchiyama, Minoru ^a   Komokata, Yuko ^a   Tanaka, Yorihisa ^a   Takahagi, Hidekuni ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

a HMG CoA reductase inhibitor; enzyme linked immunosorbent assay; human plasma; N succinimidyl ester method; pravastatin sodium

Indexed keywords

ANTIGEN; HORSERADISH PEROXIDASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PRAVASTATIN;

ANTIGEN ANTIBODY REACTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CROSS REACTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HYPERCHOLESTEROLEMIA; ORAL DRUG ADMINISTRATION;

EID: 0029871757     PISSN: 01971522     EISSN: None     Source Type: Journal    
DOI: 10.1080/01971529608005776     Document Type: Article

References (9)

1. Aral, M., Serizawa, N., Terahara, A et al. Pravastatin sodium (CS-514), a novel cholesterol-lowering agent which inhibits HMG-CoA reductase. Annu. Rep. Sankyo Res. Lab. 1988; 40: 1-38.
2. Funke, P.T., Ivashkiv, E., Arnold, M.E. and Cohen, A.I. Determination of pravastatin sodium and its major metabolites in human serum / plasma by capillary gas chromatography / negative ion chemical ionization mass spectrometry. Biomed. Environ. Mass Spectrom. 1989; 18: 904-9.
3. Morris, M.J., Gilbert, J.D., Hsieh, J.Y.-K., Matuszewski, B.K., Ramjit, H.G. and Bayne, W.F. Determination of the HMG-CoA reductase inhibitors simvastatin, lovastatin, and pravastatin in plasma by gas chromatography/chemical ionization mass spectrometry. Biol. Mass Spectrom. 1993; 22: 1-8.
4. Hosoda, H., Yoshida, H., Sakai, Y., Miyairi, S., Ishii, K. and Nambara, T. The preparation of steroid N-hydroxysuccinimide esters and their reactivities with bovine serum albumin. Chem. Pharm. Bull. 1979; 27: 742-6.
5. Hosoda, H., Karube, T., Kobayashi, N. and Nambara, T. Enzyme labeling of steroids by the N-succinimidyl ester method: Preparation of horseradish peroxidase-labeled antigen for use in enzyme immunoassay. Chem. Pharm. Bull. 1985; 33: 249-55.
6. Hosoda, H., Takasaki, W., Oe, T., Tsukamoto, R. and Nambara, T. A comparison of chromogenic substrates for horseradish peroxidase as a label in steroid enzyme immunoassay. Chem. Pharm. Bull. 1986; 34: 4177-82.
7. Sasahara, K., Kawabata, K., Nakaya, N. and Goto, Y. Phase I study of CS-514, an inhibitor of HMG-CoA reductase (II) : Pharmacokinetics of CS-514 in helthy volunteers. Rinsho Iyaku 1998; 4: 45-65
8. Kawabata, K., Hoshiyama, K., Suzuki, S., Nitanai, T. and Sasahara, K. Quantitation methods of pravastatin and its metabolites in human biological fluids using automated gas Chromatographic / mass spectrometry and their application to pharmacokinetic studies in volunteers and patients. Proc. Jpn. Soc. Biomed. Mass Spectrom. 1991; 16: 149-52.
9. Tsay, H., Reiss, A., Stouffer, B. et al. A specific radioimmunoassay for the measurement of pravastatin in human serum. Clin. Chem. 1989; 35: 1189.