Decreased ventilatory response to hypoxia in sedated newborn piglets prenatally exposed to cocaine

Journal of Pediatrics

Volumn 128, Issue 3, 1996, Pages 389-395

  Suguihara, C ^a   Hehre, D ^a   Huang, J ^a   Devia, C ^a   Bancalari, E ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; COCAINE; DOPAMINE RECEPTOR BLOCKING AGENT; METENKEPHALIN; SUBSTANCE P;

ACID BASE BALANCE; ANIMAL MODEL; APNEA; ARTICLE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; GESTATIONAL AGE; HYPOXIA; METABOLIC PARAMETERS; NEWBORN; NONHUMAN; OXYGEN CONSUMPTION; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RESPIRATION CONTROL; RESPIRATION DEPRESSION; SEDATION; SWINE;

EID: 0029871753     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3476(96)70290-1     Document Type: Article

References (28)

1. C Suguihara E. Bancalari Substance abuse during pregnancy: effects on respiratory function in the infant Semin Perinatol 15 1991 302 309
2. IJ Chasnoff CE Hunt R Kletter D. Kaplan Prenatal cocaine exposure is associated with respiratory pattern abnormalities Arch Pediatr Adolesc Med [Am J Dis Child] 143 1989 583 587
3. C Chen S Duara GS Neto Respiratory instability in neonates with in utero exposure to cocaine J PEDIATR 19 1991 111 113
4. SL Davidson Ward DB Bautista S Schuetz L Wachsman X Bean TG. Keeus Abnormal hypoxic arousal responses in infants of cocaine-abusing mothers Ann NY Acad Sci 562 1989 347 348
5. JL Gingras A Muelenaer LB Dalley KJ O'Donnell Prenatal cocaine exposure alters postnatal hypoxic arousal responses and hypercarbic ventilatory responses but not pneumocardiograms in prenatally cocaine-exposed term infants Pediatr Pulmonol 18 1994 13 20
6. SL Davidson Ward D Bautista L Chan Sudden infant death syndrome in infants of substance-abusing mothers J PEDIATR 117 1990 876 881
7. DJ Durand AM Espinoza BG. Nickerson Association between prenatal cocaine exposure and sudden infant death syndrome J PEDIATR 117 1990 909 911
8. T Trippenbach G. Kelly Effects of acute and chronic cocaine on breathing and chemosensitivity in awake rats Am J Physiol 266 1994 R696 R701
9. RM Harper RR Terreberry CA Richard RK. Harper Upper airway and diaphragmatic muscle activity following acute cocaine administration Pharmacol Biochem Behav 39 1991 137 142
10. DE Weese-Mayer LM Klemka-Walden GA Barkov JL. Gingras Effects of perinatal cocaine on the ventilatory response to hypoxia in newborn rabbits Dev Pharmacol Ther 18 1992 116 124
11. DE Weese-Mayer GA. Barkov Effect of cocaine in early gestation: physiologic responses to hypoxia in newborn rabbits Am Rev Respir Dis 148 1993 589 596
12. GD Olsen JA. Weil In utero cocaine exposure: effect on neonatal breathing in guinea pigs J Pharmacol Exp Ther 261 1991 420 428
13. SA Book LK. Bustad The fetal and neonatal pig in biomedical research J Anim Sci 38 1974 997 1002
14. C Suguihara C Devia S Rose J Huang E Orchard D. Hehre Pharmacodynamics of cocaine in pregnant sows: a chronic drug administration model Pediatr Res 33 1993 69A [Abstract]
15. P Wilkinson C Van Dyke P Jatlow P Barash R. Byck Intranasal and oral cocaine kinectics Clin Pharmacol Ther 27 1980 386 394
16. C Suguihara E Bancalari D Hehre S Duara T. Gerhardt Changes in ventilation and oxygen consumption during acute hypoxia in sedated newborn piglets Pediatr Res 35 1994 536 540
17. CE Blanco MA Hanson P Johnson H. Rigatto Breathing pattern of kittens during hypoxia J Appl Physiol 56 1984 12 17
18. C Suguihara D Hehre E. Bancalari Effect of dopamine on hypoxic ventilatory response of sedated piglets with intact and denervated carotid bodies J Appl Physiol 77 1994 285 289
19. TR Moore J Sorg L Miller TC Key R. Resnik Hemodynamic effects of intravenous cocaine on the pregnant ewe and fetus Am J Obstet Gynecol 155 1986 883 888
20. JK Woods MA Plessinger V Scott RK. Miller Prenatal cocaine exposure to the fetus: a sheep model for cardiovascular evaluation Ann N Y Acad Sci 562 1989 267 279
21. JA Madden RH. Powers Effect of cocaine and cocaine metabolites on cerebral arteries in vitro Life Sci 47 1990 110914
22. C Suguihara E Bancalari D Hehre H. Osiovich Effect of alpha-adrenergic blockade on brain blood flow and ventilation during hypoxia in newborn piglets J Dev Physiol 15 1991 28995
23. F Leon-Velarde L Huicho CC. Monge Effects of cocaine on oxygen consumption and mitrochondrial respiration in normoxic and hypoxic mice Life Sci 50 1992 213 218
24. JP Mortola R. Rezzonico Metabolic and ventilatory rates in newborn kittens during acute hypoxia Respir Physiol 73 1988 55 68
25. MA Bureau R. Begin Depression of respiration induced by metabolic acidosis in newborn lambs Biol Neonate 42 1982 279 283
26. Q Yu C Suguihara H Navarro D Hehre J Huang E. Bancalari Effects of chloral hydrate (CH) on the cardiorespiratory response to hypoxia in newborn piglets Pediatr Res 35 1994 262A [Abstract]
27. JL Gingras D. Weese-Mayer Maternal cocaine addiction. II. An animal model for the study of brain-stem mechanisms operative in sudden infant death syndrome Med Hypotheses 33 1990 231 234
28. C Suguihara J Huang D Flynn C Devia D Hehre E. Bancalari Central nervous system dopamine receptors in piglets prenatally exposed to cocaine Pediatr Res 33 1993 69A [Abstract]