Delayed and diminished presser response to muscle sympathetic nerve activity in the elderly

Journal of Applied Physiology

Volumn 80, Issue 3, 1996, Pages 869-875

  Sugiyama, Yoshiki ^a   Matsukawa, Toshiyoshi ^a   Shamsuzzaman, A S M ^a   Okada, Hisashi ^a   Watanabe, Takemasa ^a   Mano, Tadaaki ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

End organ responsiveness; Human; Maximum entropy method

Indexed keywords

ALPHA ADRENERGIC RECEPTOR;

AGED; AGING; ARTICLE; CARDIOVASCULAR AUTOREGULATION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; SYMPATHETIC TONE;

ADULT; AGE FACTORS; AGED; AGING; BLOOD PRESSURE; ELECTROCARDIOGRAPHY; HEART RATE; HUMANS; MALE; REACTION TIME; RESPIRATION; SYMPATHETIC NERVOUS SYSTEM;

EID: 0029871703     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.80.3.869     Document Type: Article

References (30)

1. Akselrod, S., D. Gordon, J. B. Madwed, N. C. Snidman, D. C. Shannon, and R. J. Cohen. Hemodynamic regulation: investigation by spectral analysis. Am. J. Physiol. 249 (Heart Circ. Physiol. 18): H867-H875, 1985.
2. Bühler, F. R., W. Kiowski, P. van Brummelen, F. W. Amann, O. Bertel, R. Landmann, B. E. Lütold, and P. Bolli. Plasma catecholamines and cardiac, renal and peripheral vascular adrenoreceptor-mediated responses in different age groups of normal and hypertensive subjects. Clin. Exp. Hypertens. 2: 409-426, 1980.
3. Cunningham, D.A., R. J. Petrella, D. H. Paterson, and P. M. Nichol. Comparison of cardiovascular response to passive tilt in young and elderly men. Can. J. Physiol. Pharmacol. 66: 1425-1432, 1988.
4. Ebert, T. J., B. J. Morgan, J. A. Barney, T. Denahan, and J. J. Smith. Effects of aging on baroreflex regulation of sympathetic activity in humans. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H798-H803, 1992.
5. Elliott, H. L., D. J. Sumner, K. McLean, and J. L. Reid. Effect of age on the responsiveness of vascular α-adrenoreceptors in man. J. Cardiovasc. Pharmacol. 4: 388-392, 1982.
6. Fagius, J., B. G. Wallin, G. Sundlöf, C. Nerhed, and S. Englesson. Sympathetic outflow in man after anaesthesia of the glossopharyngeal and vagus nerves. Brain 108: 423-438, 1985.
7. Fleisch, J. H. Age-related changes in the sensitivity of blood vessels to drugs. Pharmacol. Ther. 8: 477-487, 1988.
8. Gribbin, B., T. G. Pickering, P. Sleight, and R. Peto. Effect of aging and high blood pressure on baroreflex sensitivity in man. Circ. Res. 29: 424-429, 1971.
9. Hayano, J., J. A. Taylor, A. Yamada, R. Mukai, T. Asakawa, K. Yokoyama, Y. Watanabe, K. Tanaka, and T. Fujinami. Continuous assessment of hemodynamic control by complex demodulation of cardiovascular variability Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H1229-H1238, 1993.
10. Inamura, K., T. Mano, S. Iwase, Y. Amagishi, and K. Aoki. Low frequency components of the body's center of gravity and blood circulation. Front. Med. Biol. Eng. 3: 139-144, 1991.
11. Iwase, S., T. Mano, T. Watanabe, M. Saito, and F. Kobayashi. Age-related changes of sympathetic outflow to muscles in humans. J. Gerontol. 46: M1-M5, 1991.
12. Kuramoto, K., S. Matsushita, J. Mifune, M. Saka, and M. Murakami. Electrocardiographic and hemodynamic evaluation of isoproterenol test in eldery subjects. Jpn. Circ. J. 42: 955-960, 1978.
13. Lakatta, E. G. Alterations in the cardiovascular system that occur in advanced age. Federation Proc. 38: 163-167, 1979.
14. Madwed, J. B., P. Albrecht, R. G. Mark, and R. J. Cohen. Low-frequency oscillations in arterial pressure and heart rate: a simple computer model. Am. J. Physiol. 256 (Heart Circ. Physiol. 25). H1573-H1579, 1989.
15. Mano, T. Sympathetic nerve mechanisms of human adaptation to environment - findings obtained by recent microneurographic studies. Environ. Med. 34: 1-35, 1990.
16. Matsukawa, T., E. Gotoh, O. Hasegawa, H. Shionoiri, O. Tochikubo, and M. Ishii. Reduced baroreflex changes in muscle sympathetic nerve activity during blood pressure elevation in essential hypertension. J. Hypertens. 9: 537-542, 1991.
17. Ng, A. V., R. Callister, D. G. Johnson, and D. R. Seals. Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension Dallas 21: 498-503, 1993.
18. Ng, A. V., R. Callister, D. G. Johnson, and D. R. Seals. Sympathetic neural activity to stress does not increase with age in healthy humans. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H344-H353, 1994.
19. Ohtomo, N., S. Terachi, Y. Tanaka, K. Tokiwano, and N. Kaneko. New method of time series analysis and its application to Wolfs sunspot number data. Jpn. J. Appl. Physiol. 33: 2821-2831, 1994.
20. Palmer, J. G., M. G. Ziegler, and C. R. Lake. Response of norepinephrine and blood pressure to stress increases with age. J. Gerontol. 33: 482-487, 1978.
21. Pfeifer, M. A., C. R. Weinberg, D. Cook, J. D. Best, A. Reenan, and J. B. Halter. Differential changes of autonomic nervous system function with age in man. Am. J Med. 75: 249-258, 1983.
22. Pickering, T. G., B. Gribbin, and P. Sleight. Comparison of the reflex heart rate response to rising and falling arterial pressure in man. Cardiovasc. Res. 6: 277-283, 1972.
23. Rea, R. F., and B. G. Wallin. Sympathetic nerve activity in arm and leg muscles during lower body negative pressure in humans. J. Appl. Physiol. 66: 2778-2781, 1989.
24. Sundlöf, G., and B. G. Wallin. Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age. J. Physiol. Lond. 274: 621-637, 1978.
25. Taylor, J. A., G. A. Hand, D. G. Johnson, and D. R. Seals. Sympathoadrenal-circulatory regulation during sustained isometric exercise in young and old men. Am. J. Physiol. 261 (Regulatory Integrative Comp. Physiol. 30): R1061-R1069, 1991.
26. Taylor, J. A., G. A. Hand, D. G. Johnson, and D. R. Seals. Sympathoadrenal-circulatory regulation of arterial pressure during orthostatic stress in young and older men. Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 32): R1147-R1155, 1992.
27. Tuttle, R. S. Age-related changes in the sensitivity of rat aortic strips to norepinephrine and associated chemical and structural alterations. J. Gerontol. 21: 510-516, 1966.
28. Veith, R. C., J. A. Featherstone, O. A. Linares, and J. B. Halter. Age differences in plasma norepinephrine kinetics in humans. J. Gerontol. 41: 319-324, 1986.
29. Victor, R. G., and E. L. Leimbach. Effects of lower body negative pressure on sympathetic discharge to leg muscles in humans. J. Appl. Physiol. 63: 2558-2562, 1987.
30. Wallin, B. G., and C. Nerhed. Relationship between spontaneous variations of muscle sympathetic activity and succeeding changes of blood pressure in man. J. Auton. Nerv. Syst. 6: 293-302, 1982.