Calpains in the human lens: Relations to membranes and possible role in cataract formation

Ophthalmic Research

Volumn 28, Issue 1, 1996, Pages 51-54

  Andersson, Madeleine ^a   Sjostrand J ^a   Karlsson, J O ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Calpains; Calpastatin; Cataract; Lens; Proteolysis

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM CHANNEL; CALPAIN; CALPASTATIN; CRYSTALLIN; CYTOSKELETON PROTEIN; PROTEIN KINASE; PROTEIN KINASE C; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CAPSULORHEXIS; CATARACTOGENESIS; CONFERENCE PAPER; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; LENS; LENS EPITHELIUM; MEMBRANE; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

CALCIUM; CALCIUM-BINDING PROTEINS; CALPAIN; CATARACT; EPITHELIUM; HUMANS; LENS, CRYSTALLINE; SUBSTRATE SPECIFICITY;

EID: 0029871418     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000267944     Document Type: Article

References (25)

1. Croall DE, DeMartino GN: Calcium-activated neutral proteasc (calpain) system: Structure, function and regulation Physiol Rev 1991:71: 813-847.
2. Billgcr M, Wallin M, Karlsson J-O: Proteolysis of tubulin and microtu-bule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules. Cell Calcium 1988;9:33-44.
3. Salamino E, Sparatorc B, Mclloni E, Michotti M, Viotti PI, Pontremoli S, Carafoli E: The plasma membrane calcium pump is the preferred calpain substrate within the erythrocyte. Cell Calcium 1994; 15:28-35.
4. Belles B, Hescheler J, Trautwein W, Blomgrcn K, Karlsson J-O: A possible physiological role of the Ca-de-pendent protease calpain and its inhibitor calpastatin on the Ca current in guinea pig myocytes. Pfliigers Arch 1988;412:554-556.
5. Blomgren K, Nilsson E, Karlsson J-O: Calpain and calpastatin levels in different organs of the rabbit. Comp Biochem Physiol 1989;93B: 403-407.
6. Karlsson J-O, Blcnnow K, Holm-berg B, Janson I, Karlsson I, Nilsson F, Wallin A, Gottfrics CG: Increased proteolytic activity in erythrocytes from patients with Alzheimer’s disease. Dementia 1992:3: 200-204.
7. Ostwald K, Hagberg H, Andinc P, Karlsson J-O: Upregulation of calpain activity in neonatal rat brain after hypoxic-ischemia. Brain Res 1993;630:289-294.
8. Blomgren K, Karlsson J-O: Developmental changes of calpain and calpastatin in rabbit brain. Neuro-chem Res 1989;14:1149-1152.
9. 2+-de-pendent cysteine proteinase, isolated from the same tissue. Biochim BiophysActa 1984;798:252-259.
10. Yoshida H, Murachi T, Tsukahara I: Age-related changes of calpain II and a-crystallin in the lens of hereditary cataract (Nakano) mouse. Curr Eye Res 1985;4:983.
11. David LL. Shearer TR: Purification of calpain II from rat lens and determination of endogenous substrates. Exp Eye Res 1986;42:227.
12. David LL, Varnum MD, Lampi KJ, Shearer TR: Calpain II in human lens. Invest Ophthalmol Vis Sci 1989;30:269-275.
13. Yoshida H, Murachi T, Tsukahara I: Distribution of calpain 1, calpain II. and calpastatin in bovine lens. Invest Ophthalmol Vis Sci 1985;26: 953-995.
14. Yoshida H, Murachi T, Tsukahara I: Degradation of action and vimen-tin by calpain II, a Ca-dependent cysteine proteinase, in bovine lens. FEBS Lett 1984:170:259.
15. David LL, Shearer TR: β-Crystallins insolubilizcd by calpain II in vitro contain cleavage sites similar to β-crystallins insolubilized during cataract. FEBS Lett 1993;324:265-270.
16. Marcantonio JM, Duncan G: Calcium-induced degradation of the lens cytoskeleton. Biochem Soc Trans 1991;19:1148-1150
17. David LL, Takemoto LJ, Anderson RS, Shearer TR: Proteolytic changes in main intrinsic polypeptide (MIP26) from membranes in selenite cataract. Curr Eye Res 1988:7: 411-417.
18. Azuma M, David LL, Shearer TR: Cysteine proteasc inhibitor E64 reduces the rate of formation of selenite cataract in the whole animal. Curr Eye Res 1991:7:657-666.
19. Anderson RS, Shearer TR, Clay-comb CK: Selenite-induced epithelial damage and cortical cataract. Curr Eye Res 1986;5:53-61.
20. Robinson WG, Houlder N, Kinoshi-ta JH: The role of lens epithelium in sugar cataract formation. Exp Eye Res 1990;50:641-646.
21. Hightower KR, McCrcady JP: Effect of selenite on epithelium of cultured rabbit lens. Invest Ophthalmol Vis Sci 1991;32:406-409.
22. Andersson M, Sjôstrand J, Anders-son AK, Andersen B, Karlsson J-O: Calpainsin lens epithelium from patients with cataract. Exp Eye Res 1994;59:359-364.
23. Duncan G, Bushell AR: Ion analysis of human cataractous lenses. Exp Eye Res 1975;20:223-230.
24. Clark JI, Mengel L, BaggA, Benedek GB: Cortical opacity, calcium concentration and fiber membrane structure in the calf lens. Exp Eye Res 1980:31:399-410.
25. Marcantonio J, Duncan G, Rink H: Calcium-induccd opacification and loss of protein in the organ-cultured bovine lens. Exp Eye Res 1986;42: 617-630.