Ethanol increases uterine blood flow and fetal arterial blood oxygen tension in the near-term pregnant ewe

Alcohol

Volumn 13, Issue 3, 1996, Pages 251-256

  Reynolds, James D ^a   Penning, Donald H ^a   Dexter, Franklin ^a   Atkins, Barry ^a   Hrdy, Jim ^a   Poduska, Dan ^a   Brien, James F ^b  

^a UNIVERSITY OF IOWA   (United States)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

Ethanol teratogenesis; Fetal arterial P(O2); Fetal hypoxia; Sheep; Uterine blood flow

Indexed keywords

ALCOHOL;

ALCOHOL BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; ELECTROMAGNETIC FLOWMETER; FEMALE; FETUS BLOOD; FETUS HYPOXIA; NONHUMAN; OXYGEN TENSION; SHEEP; TERATOGENESIS; UTERINE ARTERY; UTERUS BLOOD FLOW;

EID: 0029869829     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/0741-8329(95)02051-9     Document Type: Article

References (35)

1. Abel, E. L. Fetal alcohol syndrome. II. Human studies. Boca Raton, FL: CRC Press; 1982.
2. Abel, E. L. Fetal alcohol syndrome. III. Animal studies. Boca Raton, FL: CRC Press; 1982.
3. Altura, B. M.; Altura, B. T.; Carella, A.; Chatterjee, M.; Halvey, S.; Tejani, N. Alcohol produces spasms of human umbilical blood vessels: Relationship to fetal alcohol syndrome. Eur. J. Pharmacol. 86:311-312; 1982.
4. Amankwah, K. S.; Kaufmann, R. C. Ultrastructure of human placenta: Effects of maternal drinking. Gynecol. Obstet. Invest. 18:311-316; 1984.
5. Ayromlooi, J.; Tobias, M.; Berg, P. D.; Desiderio, D. Effects of ethanol on the circulation and acid-base balance of pregnant sheep. Obstet. Gynecol. 54:624-630; 1979.
6. Baldwin, V. J.; MacLeod, P. M.; Bernirschke, K. Placental findings in alcohol abuse in pregnancy. Birth Defects 18:89-94; 1982.
7. Battaglia, F. C.; Meschia, G. An introduction to fetal physiology. Orlando: Academic Press Incorporated; 1986.
8. Bilardo, C. M.; Nicolaides, K. H.; Campbell, S. Doppler measurements of fetal and uteroplacental circulations: relationship with umbilical venous blood gases measured at corocentesis. Am. J. Obstet. Gynecol. 162:115-120; 1990.
9. 2, and myometrial activity. Am. J. Physiol. 266:R1297-R1301; 1994.
10. 2 during ethanol infusion. Am. J. Physiol. 265:R640-R645; 1993.
11. Brien, J. F.; Smith, G. N. Effects of alcohol (ethanol) on the fetus. J. Dev. Physiol. 15:21-32; 1991.
12. Clarren, S. K.; Smith, D. W. The fetal alcohol syndrome. N. Engl. J. Med. 298:1063-1067; 1978.
13. Cook, P. S.; Abrams, R. M.; Notelovitz, M.; Frisinger, J. E. Effect of ethyl alcohol on maternal and fetal acid-base balance and cardiovascular status in chronic sheep preparations. Br. J. Obstet. Gynecol. 88:188-194; 1981.
14. Cumming, M. E.; Ong, B. Y.; Wade, J. G.; Sitar, D. S. Maternal and fetal ethanol pharmacokinetics and cardiovascular responses in near-term pregnant sheep. Can. J. Physiol. Pharmacol. 62: 1435-1439; 1984.
15. Dilts, P. V. Effects of ethanol on maternal and fetal acid-base balance. Am. J. Obstet. Gynecol. 107:1018-1021; 1970.
16. Eisenach, J. C. Uteroplacental blood flow. In: Chestnut, D. H., ed. Obstetric anesthesia. Principles and practice. St. Louis: Mosby Year Book, Inc.; 1994:43-54.
17. Erskine, R. L. A.; Ritchie, J. W. K. The effects of maternal consumption of alcohol on human umbilical artery blood flow. Am. J. Obstet. Gynecol. 154:318-321; 1986.
18. Fuchs, F. Use of ethanol in prevention of premature delivery. Am. J. Obstet. Gynecol. 110:1148-1149; 1971.
19. Gleason, C. A.; Hotchkiss, K. J. Cerebral responses to acute maternal alcohol intoxication in immature fetal sheep. Pediatr. Res. 31:654-648; 1992.
20. Jensen, A.; Berger, R. Fetal circulatory responses to oxygen lack. J. Dev. Physiol. 16:181-207; 1991.
21. Mukherjee, A. B.; Hodgen, G. D. Maternal ethanol exposure induces transient impairment of umbilical circulation and fetal hypoxia in monkeys. Science 218:700-702; 1982.
22. Patrick, J.; Carmichael, L.; Richardson, B.; Smith, G.; Howman, J.; Brien, J. Effects of multiple-dose maternal ethanol infusion on fetal cardiovascular and brain activity in lambs. Am. J. Obstet. Gynecol. 158L:1424-1429; 1988.
23. Penning, D. H.; Chestnut, D. H.; Dexter, F.; Hrdy, J.; Poduska, D.; Atkins, B. Glutamate release from the ovine fetal brain during maternal hemorrhage. Anesthesiology 82:521-530; 1995.
24. 2 on ovine maternal placental blood flow. Am. J. Physiol. 231:754-759; 1976.
25. Reynolds, J. D.; Penning, D. H.; Atkins, B.; Dexter, F.; Hrdy, J.; Poduska, D.; Brien, J. F. Effect of maternal administration of ethanol or cocaine, or maternal hemorrhage on uterine blood flow and fetal oxygen status in the near-term pregnant ewe. Alcohol. Clin. Exp. Res. 19(Suppl):21A; 1995.
26. Reynolds, J. D.; Penning, D. H.; Dexter, F.; Atkins, B.; Hrdy, J.; Poduska, D.; Chestnut, D. H.; Brien, J. F. Dose-dependent effects of acute in vivo ethanol exposure on extracellular glutamate concentration in the cerebral cortex of the near-term fetal sheep. Alcohol. Clin. Exp. Res. 19:1447-1453; 1995.
27. Richardson, B. S.; Patrick, J. E.; Bousquet, J.; Homan, J.; Brien, J. F. Cerebral metabolism in fetal lamb after maternal infusion of ethanol. Am. J. Physiol. 249:R505-R509; 1985.
28. Savoy-Moore, R. T.; Dombrowski, M. P.; Cheng, A.; Abel, A. E.; Sokol, R. J. Low dose alcohol contracts the human umbilical artery in vitro. Alcohol. Clin. Exp. Res. 13:40-42; 1989.
29. Schenker, S.; Becker, H. C.; Randall, C.; Phillips, D. K.; Baskin, G. S.; Henderson, G. J. Fetal alcohol syndrome: Current state of pathogenesis. Alcohol. Clin. Exp. Res. 14:635-647; 1990.
30. Skillman, C. A.; Plessinger, M. A.; Woods, J. R.; Clarke, K. E. Effect of graded reductions in uteroplacental blood flow on the fetal lamb. Am. J. Physiol. 149:1098-1105; 1985.
31. Smith, G. N.; Brien, J. F.; Carmichael, L.; Clarke, D. W.; Patrick, J. Effect of acute, multiple-dose ethanol on maternal and fetal blood gases and acid-base balance in the near-term pregnant ewe. Can. J. Physiol. Pharmacol. 67:686-688; 1989.
32. Smith, G. N.; Patrick, J.; Sinervo, K. R.; Brien, J. F. Effects of ethanol exposure on the embryo-fetus: Experimental considerations, mechanisms, and the role of prostaglandins. Can. J. Physiol. Pharmacol. 69:550-569; 1990.
33. Steenaart, N. A. E.; Clarke, D. W.; Brien, J. F. Gas-liquid chromatographic analysis of ethanol and acetaldehyde in blood with minimal artifactual acetaldehyde formation. J. Pharmacol. Methods. 14:199-212; 1985.
34. Terpstra, P. J. The exact probability distribution of the T statistic for testing against trend and its normal approximation. Proc. K. Akad. Wet. Amst. A 56:433-437; 1953.
35. West, J. R.; Chen, W. A.; Pantazis, N. J. Fetal alcohol syndrome: The vulnerability of the developing brain and possible mechanisms of damage. Metab. Brain Dis. 9:291-322; 1994.