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It must be noted that if the enantioselective synthesis of 2-substituted pyrrolidines have received much attention (6), reports on the synthesis of unsaturated analogs are scarce (7)
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It must be noted that if the enantioselective synthesis of 2-substituted pyrrolidines have received much attention (6), reports on the synthesis of unsaturated analogs are scarce (7).
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13C NMR spectra have been registered at 60°C
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13C NMR spectra have been registered at 60°C.
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85083121461
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This observation is in good agreement with the results reported by Fukumoto for the formation of chiral pyrrolidines via a similar intramolecular Michael reaction (see reference 14c)
-
This observation is in good agreement with the results reported by Fukumoto for the formation of chiral pyrrolidines via a similar intramolecular Michael reaction (see reference 14c).
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