Loss of heterozygosity in chromosome 4q12-q13 in hepatocellular carcinoma in Southern African blacks

Anticancer Research

Volumn 16, Issue 1, 1996, Pages 349-352

  Leon, Malcolm ^a   Kew, Michael C ^a,b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND MEDICAL SCHOOL   (South Africa)

Author keywords

fetoprotein; Chromosome 4q12 q13; Hepatitis B virus; Hepatocellular carcinoma; Loss of heterozygosity; PCR minisatellite DNA technique; Southern African blacks

Indexed keywords

ALPHA FETOPROTEIN; DNA MINISATELLITE;

ARTICLE; CHROMOSOME 4Q; CLINICAL ARTICLE; DNA FLANKING REGION; GENE LOCUS; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; JAPAN; LIVER CELL CARCINOMA; NEGRO; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RACE DIFFERENCE; SOUTH AFRICA;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; ALPHA-FETOPROTEINS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CHROMOSOMES, HUMAN, PAIR 4; GENE DELETION; HETEROZYGOTE; HUMANS; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; SOUTH AFRICA;

EID: 0029869548     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Feitelson M: Hepatitis B Virus infection and primary hepatocellular carcinoma. Clin Microbiol Rev 5: 275-301, 1992.
2. Hansen MF, Cavenee WK: Genetics of cancer predisposition. Cancer Res 47: 5518-5527, 1987.
3. Ding S-F, Habib NA: Loss of heterozygosity in liver tumours. J Hepatology 22: 230-238, 1995.
4. Sakai M, Morinaga T, Urano Y, Watanabe K, Wegmann TG, Tamaoki T: The human α-fetoprotein gene. J Biol Chem 260: 5055-5060, 1985.
5. Gibbs PEM, Zielinski R, Boyd C, Dugaiczyk A: Structure, polymorphism, and novel repeated DNA elements revealed by a complete sequence of the human α-fetoprotein gene. Biochemistry 26: 1332-1343, 1987.
6. Buetow KH, Murray JC, Israel JL, London WT, Smith M, Kew MC, Blanquet V, Brechot C, Redeker A, Govindarajan S: Loss of heterozygosity suggests tumour suppressor gene responsible for primary hepatocellular carcinoma. Proc Natl Acad Sci (USA) 86: 8852-8856, 1989.
7. Toyota M, Hinoda Y, Nakano T, Imai K, Yachi A: A new restriction fragment length polymorphism of the human α-fetoprotein gene in Japanese individuals: detection of loss of heterozygosity in human hepatocellular carcinoma. Tum Biol 13: 133-137, 1992.
8. Fujimori M, Tokino T, Hino O, Kitagawa T, Imamura T, Okamoto E, Mitsunobu M, Ishikawa T, Nakagama H, Harada H, Yagura M, Matsubara K, Nakamura Y: Allelotype study of primary hepatocellular carcinoma. Cancer Res 51: 89-93, 1991.
9. Zhang W, Hirohashi S, Tsuda H, Shimosato Y, Yokota J, Terada M, Sugimura T: Frequent loss of heterozygosity on chromosomes 16 and 4 in human hepatocellular carcinoma. Jpn J Cancer Res 81: 108-111, 1990.
10. Walker GJ, Hayward NK, Falvey S, Cooksley WG: Loss of somatic heterozygosity in hepatocellular carcinoma. Cancer Res 51: 4367-4370, 1991
11. Armour JAL, Jeffreys AJ: Biology and applications of human minisatellite loci. Curr Opinion Genetics & Dev 2: 850-856, 1992.
12. Sykes BC: DNA in heritable disease. Lancet 2: 707-708, 1983.