Posttranscriptional aspects of the biosynthesis of type 1 collagen pro-alpha chains: The effects of posttranslational modifications on synthesis pauses during elongation of the pro α1(I) chain

Journal of Cellular Biochemistry

Volumn 61, Issue 2, 1996, Pages 194-215

  Gura, Trisha ^a   Hu, Geng ^a   Veis, Arthur ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; PROCOLLAGEN;

ANIMAL CELL; ARTICLE; DISULFIDE BOND; FIBROBLAST CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS;

ANIMALS; CELL LINE; DISULFIDES; GLYCOSYLATION; HYDROXYLATION; MICE; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL; PEPTIDE FRAGMENTS; POLYRIBOSOMES; PROCOLLAGEN; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA PROCESSING, POST-TRANSCRIPTIONAL; TIME FACTORS;

EID: 0029869463     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19960501)61:2<194::AID-JCB4>3.0.CO;2-P     Document Type: Article

References (31)

1. Bergman LW, Kuehl WM (1977): Addition of glucosamine and mannose to nascent immunoglobulin heavy chains. Biochemistry 16:4490-4497.
2. Bienkowski RB, Cowan MJ, Mcdonal JA, Crystal KG (1978): Degradation of newly synthesized collagen. J Biol Chem 253:4356-4363.
3. Brownell AG, Veis A (1975): The intracellular location of glycosylation of hydroxylysine of collagen. Biochem Biophys Res Commun 63:371-377.
4. Brownell AG, Veis A (1976): Intracellular location of triple helix formation of collagen. Enzyme probe studies. J Biol Chem 251:7137-7143.
5. Clark CC (1979): The distribution and initial characterization of oligosaccharide units on the COOH-terminal pro-peptide extensions of the pro-α1 and pro α2 chains of type I procollagen. J Biol Chem 254:10798-10802.
6. de Wet WJ, Chu M-L, Prockop DJ (1983): The mRNAs for the pro-α1(I) and pro-α2(I) chains of type I procollagen are translated at the same rate in normal human fibroblasts and in fibroblasts from two variants of Osteogenesis Imperfecta with altered steady state ratios of the two mRNAs. J Biol Chem 258:14385-14389.
7. Duksin D, Bornstein P (1977): Impaired conversion of procollagen to collagen by fibroblasts and bone treated with tunicamycin, an inhibitor of protein glycosylation. J Biol Chem 252:955-962.
8. Gilmore R, Blobel G (1985): Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants. Cell 42:497-505.
9. Horlein D, McPherson J, Goh SH, Bornstein P (1981): Regulation of protein synthesis: Translational control by procollagen-derived fragments. Proc Natl Acad Sci USA 78:6163-6167.
10. Hu G, Tylzanowski P, Inoue H, Veis A: Relationships between translation of pro α1(I) and pro α2(I) mRNAs during synthesis of the Type I procollagen heterotrimer. J Cell Biochem 59:214-234.
11. Hu G, Gura T, Sabsay B, Sauk J, Dixit SN, Veis A: The Endoplasmic Reticulum Protein Hsp47 Binds Specifically to the N-Terminal Globular Domain of the Amino-Propeptide of the Procollagen I α1(I)-Chain. J Cell Biochem 59:350-367.
12. Kirk TZ, Evans JS, Veis A (1987): Biosynthesis of Type I Collagen. Characterization of the distribution of chain sizes and extent of hydroxylation of polysome associated pro α chains. J Biol Chem 262:5540-5545.
13. Laemmli UK (1970): Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
14. Lee S-T, Smith BD, Greenspan D (1988): Construction of a full length cDNA encoding human pro α2(I) collagen and its expression in pro α2(I)-deficient W8 rat cells. J Biol Chem 263:13414-13418.
15. Lazarides EL, Lukens LN, Infante AA (1971): Collagen polysomes: Site of hydroxylation of proline residues. J Mol Biol 58:831-846.
16. Marsilio R, Sobel ME, Smith BD (1984): Absence of procollagen α2(I) mRNA in chemically transformed rat liver epithelial cells. J Biol Chem 259:1401-1404.
17. Moazed D, Noller HF (1989): Intermediate states in the movement of transfer RNA in the ribosome. Nature 342:142-148.
18. Olsen AS, Prockop DJ (1989): Transcription of human type I collagen genes. Matrix 9:73-81.
19. Perlish JS, Timpl R, Fleischmajer R (1985): Collagen synthesis regulation by the aminopropeptide of procollagen I in normal and scleroderma fibroblasts. Arthritis Rheum 38:647-651.
20. Ramaley PB, Rosenbloom L (1971): Inhibition of proline and lysine hydroxylation prevents normal extrusion of collagen by 3T6 fibroblasts in culture. FEBS Lett 15:59-64.
21. Rosenbloom J, Prockop DJ (1971): Incorporation of cis-hydroxyproline into protocollagen and collagen. Collagen containing cis-hydroxyproline in place of proline and trans-hydroxyproline is not extruded at a normal rate. J Biol Chem 246:1549-1555.
22. Sandell L, Veis A (1980): The molecular weight of the cell-free translation product of α1(I) procollagen mRNA. Biochem Biophys Res Commun 92:554-562.
23. Towbin H, Staehelin T, Gordon J (1979): Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 76:4350-1354.
24. Uitto J, Prockop DJ (1974): Hydroxylation of peptide-bound proline and lysine before and after chain completion of the polypeptide chains of procollagen. Arch Biochem Biophys 164:210-217.
25. Veis A, Brownell AG (1977): Triple-helix formation on ribosome-bound nascent chains of procollagen: Deuterium-hydrogen exchange studies. Proc Natl Acad Sci USA 74:902-905.
26. Veis A, Kirk TZ (1989): The coordinate synthesis and cotranslational assembly of Type I procollagen. J Biol Chem 264:3884-3889.
27. Veis A, Leibovich SJ, Evans J, Kirk TZ (1985): Supramolecular assemblies of mRNA direct the coordinated synthesis of type I collagen chains Proc Natl Acad Sci USA 82:3693-3697.
28. Vuust J, and Piez KA (1972): A Kinetic Study of Collagen Biosynthesis. J Biol Chem 247:856-862.
29. Vuust J, Sobel ME, Martin GR (1985): Regulation of type I collagen synthesis. Total pro α1(I) and pro α2(I) mRNAs are maintained in a 2:1 ratio under varying rates of collagen synthesis. Eur J Biochem 151:449-453.
30. Wohn SL, Walter P (1988): Ribosome pausing and stacking during translation of eukaryotic mRNA. EMBO J 7:3559-3569.
31. Wolin SL, Walter P (1989): Signal recognition particle mediates a transient arrest of preprolactin in reticulocyte lysate. J Cell Biol 109:2617-2622.