Azelaic acid decreases the fibrinolytic potential of cultured human melanoma cells in vitro

Cancer Letters

Volumn 103, Issue 2, 1996, Pages 125-129

  Addo Boadu, K ^a   Wojta, J ^a   Christ, G ^a   Hufnagl, P ^a   Pehamberger, H ^a   Binder, B R ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Azelaic acid; Fibrinolytic potential; Melanoma cells

Indexed keywords

AZELAIC ACID; FIBRINOLYTIC AGENT; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBRINOLYSIS; HUMAN; HUMAN CELL; MELANOMA CELL; NORTHERN BLOTTING; PRIORITY JOURNAL;

EID: 0029869459     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04185-7     Document Type: Article

References (16)

1. Binder, B.R, (1990) Influence of urokinase on cell proliferation and invasion. Blood Coag. Fibrinol., 1, 717-720.
2. Chomczynski, P. and Sacchi, N. (1987) Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
3. Fitton, A. and Goa, K.L. (1991) Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. Drugs, 41, 780-798.
4. Galhaup, I. (1989) Azelaic acid: mode of action at the cellular and subcellular level. Acta Dermo-Venereol., 143 (Suppl.), 75-82.
5. Grammatico, P., Scarpa, S., Steindl, K., Picardo, M., Modesti, A., Nazzaro-Porro, M. and Del Porto, G. (1991) Effect of azelaic acid on viability, ultrastructure and karyotype of melanoma cells in long-term culture. Cancer J., 4, 39-43.
6. Grammatico, P., Scarpa, S., Picardo, M., Steindl, K., Nazarro-Porro, M and Del Porto, G. (1993) Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid. Mutat. Res., 300, 119-123.
7. Leibl, H., Stingl, G., Pehamberger, H., Korschan, H., Konrad, K. and Wolff, K. (1985) Inhibition of DNA synthesis of melanoma cells by azelaic acid. J. Invest. Dermatol., 85, 417-422.
8. Mensing, H., Reimer-Hevia, C. and Schmidt, K.U. (1985) Chemotactic behaviour of melanoma cells in vitro: correlation with plasminogen activator activity and influence of azelaic acid. J. Invest. Dermatol., 84, 445.
9. Nazzaro-Porro, M. and Passi, S. (1978) Identification of tyrosinase inhibitors in cultures of pityrosporum. J. Invest. Dermatol., 71, 205-208.
10. Nazzaro-Porro, M., Passi, S., Balus, L. and Breathnach, A. (1979) Effect of dicarboxylic acids on lentigo maligna. J. Invest. Dermatol., 72, 296-305.
11. Nazzaro-Porro, M., Passi, S., Morpurgo, G. and Breathnach, A.S. (1979) Identification of tyrosinase inhibitors in cultures of pitysporum and their melanotoxic effect. Pigment Cell, 4, 234-243.
12. Nazzaro-Porro, M., Passi, S., Balus, L., Breathnach, A.S., Gallagher, S. and Morpurgo, G. (1980) Effect of azelaic acid on malignant melanoma. Lancet, i, 1109-1111.
13. Passi, S., Picardo, M., Nazzaro-Porro, M., Breathnach, A.S., Confaloni, A.M. and Serlupi-Crescenzi, G. (1984) Antimitochondrial effect of saturated medium chain length (C8-C13) dicarboxylic acids. Biochem. Pharmacol., 33, 103-108.
14. Robins, E.J., Breathnach, A.S., Ward, B.J., Bashin, Y.P., Ethridge, L., Nazzaro-Porro, M., Passi, S. and Picardo M. (1985) Effect of dicarboxylic acids on Harding-Passey and Cloudman S91 melanoma cells in tissue culture. J. Invest. Dermatol., 85, 216-221.
15. Wagner, O.F., Wojta, J., Pehamberger, H., Leibl, H. and Binder, B.R. (1985) Effect of dicarboxylic acids on plasminogen activator activity in supernatants of a human tumor cell line. Prog. Fibrinolysis, 7, 280-282.
16. Wagner, O.F., Vetterlein, M. and Binder, B.R. (1986) Purification of an active plasminogen activator inhibitor immunologically related to the endothelial type plasminogen activator inhibitor from the conditioned media of a human melanoma cell line. J. Biol. Chem., 261, 14474-14478.