Identification and characterization of a B-cell determinant within the amphipathic domain (residues 178-238) of the myelin proteolipid protein

Journal of Neuroscience Research

Volumn 43, Issue 5, 1996, Pages 545-553

  Stephens, T S ^a   Pakaski, M ^b,c   Lees, M B ^b,c   Potter, N T ^a,d  

^a UNIVERSITY OF TENNESSEE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TENNESSEE MEDICAL CENTER   (United States)

Author keywords

antibody; B cell determinant; myelin; proteolipid protein; topography

Indexed keywords

MYELIN PROTEIN; PROTEOLIPID PROTEIN;

ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; COMPETITIVE INHIBITION; CROSS REACTION; IMMUNOHISTOCHEMISTRY; MOUSE; MYELIN SHEATH; MYELINATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN;

ANIMALS; B-LYMPHOCYTES; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HUMANS; IMMUNE SERA; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED STRAINS; MYELIN PROTEOLIPID PROTEIN; RABBITS;

EID: 0029869405     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960301)43:5<545::AID-JNR4>3.0.CO;2-I     Document Type: Article

References (58)

1. Agrawal HC, Hartman BK, Shearer WT, Kalmbach S, Margolis FL (1977): Purification and immunohistochemical localization of rat brain myelin proteolipid protein. J Neurochem 28:495-508.
2. Armstrong DC, Benzig WC, Evans J, Terry RD, Shields D, Hansen LA (1989): Substance P and somatostatin coexist within neuritic plaques: Implications for the pathogenesis of Alzheimer's disease. Neuroscience 31:663-671.
3. Bottenstein JE (1986): Growth requirements in vitro of oligodendrocyte cell lines and neonatal rat brain oligodendrocytes. Proc Natl Acad Sci USA 83:1955-1959.
4. 206Cys mutation in the proteolipid protein gene causes Pelizaeus-Merzbacher disease. Am J Hum Genet 49:A972.
5. Diehl H-J, Schaich M, Budzinski R-M, Stoffel W (1986): Individual exons encode the integral membrane domains of human myelin proteolipid protein. Proc Natl Acad Sci USA 83:9807-9811.
6. Doll R, Natowicz MR, Schiffmann R, Smith FI (1992): Molecular diagnostics for myelin proteolipid protein gene mutations in Pelizaeus-Merzbacher disease. Am J Hum Genet 51:161-169.
7. Dubois-Dalcq M, Behar T, Hudson L, Lazzarini RA (1986): Emergence of three myelin proteins in oligodendrocytes cultured without neurons. J Cell Biol 102:384-392.
8. Dyer CA, Benjamins JA (1988): Antibody to galactocerebroside alters organization of oligodendroglial membrane sheets in culture. J Neurosci 8:4307-4318.
9. Fanarraga ML, Sommer IU, Griffiths IR, Montague P, Groome NP, Nave KA, Schneider A, Brophy PJ, Kennedy PG (1993): Oligodendrocyte development and differentiation in the rumpshaker mutation. Glia 9:146-156.
10. Gencic S, Abuelo D, Ambler M, Hudson LD (1989): Pelizaeus-Merzbacher disease: An X-linked neurologic disorder of myelin me-tabolism with a novel mutation in the gene encoding proteolipid protein. Am J Hum Genet 45:435-442.
11. Greer JM, Isaac JS, Lees MB (1993): Monoclonal antibodies to encephalitogenic PLP epitopes. Trans Am Soc Neurochem 24:124.
12. Gunn CA, Richards MK, Linington C (1990): The immune response to myelin proteolipid protein in the Lewis rat: Identification of the immunodominant B cell epitope. J Neuroimmunol 27:155-162.
13. Hodes ME, Pratt VM, Dlouhy SR (1993): Genetics of Pelizaeus-Merzbacher disease. Dev Neurosci 15:383-394.
14. Hudson LD (1990): Molecular genetics of X-linked mutants. Ann NY Acad Sci 605:155-165.
15. Hudson LD, Friedrich VL, Behar T, Dubois-Dalcq M, Lazzarini RA (1989a): The initial events in myelin synthesis: Orientation of proteolipid protein in the plasma membrane of cultured oligodendrocytes. J Cell Biol 109:717-727.
16. Hudson LD, Puckett C, Berndt J, Chan J, Gencic S (1989b): Mutation of the proteolipid protein gene PLP in a human X chromosome linked myelin disorder. Proc Natl Acad Sci USA 86:8128-8131.
17. Iwaki A, Muramoto T, Iwaki T, Furumi H, Dario-deLeon M, Tateishi J, Fukumaki Y (1993): A missense mutation in the proteolipid protein gene responsible for Pelizaeus-Merzbacher disease in a Japanese family. Hum Mol Genet 2:19-22.
18. Johns TG, Kerlero de Rosbo N, Menon KK, Abo S, Gonzales MF, Bernard CCA (1995): Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis. J Immunol 154:5536-5541.
19. Kobayashi H, Hoffman EP, Marks HG (1994): The rumphshaker mutation in spastic paraplegia. Nat Genet 7:351-352.
20. Koeppen AH, Ronca NA, Greenfield EA, Hans MB (1987): Defective biosynthesis of proteolipid protein in Pelizaeus-Merzbacher disease. Ann Neurol 21:159-170.
21. Konola JT, Tyler BM, Yamamura T, Lees MB (1991): Distribution of proteolipid protein and myelin basic protein in cultured mouse oligodendrocytes: Primary vs. secondary cultures. J Neurosci Res 28:49-64.
22. Konola JT, Yamamura T, Tyler BM, Lees MB (1992): Orientation of the myelin proteolipid protein C-terminus in oligodendroglial membranes. Glia 5:112-121.
23. Krchnak V, Mach O, Maly A (1989): Computer prediction of B-cell determinants from protein amino acid sequences based on incidence of β turns. Methods Enzymol 178:586-611.
24. Laursen RA, Samiullah M, Lees MB (1984): The structure of bovine brain myelin proteolipid and its organization in myelin. Proc Natl Acad Sci USA 81:2912-2916.
25. Laver WG, Air GM, Webster RG, Smith-Gill SJ (1990): Epitopes on protein antigens: Misconceptions and realities. Cell 61:553-556.
26. Lazarus KJ, Hashim GA, Paterson PY, Day ED (1984): Immunochemical cross-reactivity between intact purified myelin basic protein (MBP) and the encephalitogenic peptide S49. Neurochem Res 9:1295-1308.
27. Lees MB, Bizzozero OA (1992): Structure and acylation of proteolipid protein. In Martenson RE (ed): "Myelin: Biology and Chemistry." Boca Raton, FL: CRC Press, pp 237-255.
28. Lees MB, Brostoff SW (1984): Proteins of myelin. In Morrell P (ed): "Myelin." 2nd Ed. New York: Plenum Press, pp 197-224.
29. Lees MB, Macklin WB (1988): Myelin proteolipid protein. In Marangos PJ (ed): "Neuronal and Glial Cell Proteins: Structure, Function, and Clinical Application." Orlando: Academic Press, pp 267-293.
30. Lin L-F, Lees MB (1985): An immunologic probe for a defined region of the myelin proteolipid. J Biol Chem 260:4371-4377.
31. Linington C, Waehneldt TV (1990): Conservation of the carboxyl terminal epitope of myelin proteolipid protein in the tetrapods and lobe-finned fish. J Neurochem 54:1354-1359.
32. Linington C, Gunn CA, Lassmann H (1990): Identification of an encephalitogenic determinant of myelin proteolipid protein for the rabbit. J Neuroimmunol 30:135-144.
33. McCarthy KD, de Vellis J (1980): Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85:890-892.
34. Nussbaum J-L, Roussel G, Wunsch E, Jolles P (1985): Site-specific antibodies to rat myelin proteolipids directed against the C-terminal hexapeptide. J Neurol Sci 68:89-100.
35. Otterbach B, Stoffel W, Ramaekers V (1993): A novel mutation in the proteolipid protein gene leading to Pelizaeus-Merzbacher disease. Biol Chem Hoppe-Seyler 374:75-83.
36. Pham-Dinh D, Popot J-L, Boespflug-Tanguy O, Landrieu P, Deleuze J-F, Boue J, Jolles P, Dautigny A (1991): Pelizaeus-Merzbacher disease: A valine to phenylalanine point mutation in a putative extracellular loop of myelin proteolipid. Proc Natl Acad Sci USA. 88:7562-7566.
37. Piddlesden SJ, Lassmann H, Zimprich F, Morgan BP, Linington C (1993): The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement. Am J Pathol 143:555-564.
38. Popot J-L, Pham-Dinh D, Dautigny A (1991): Major myelin proteolipid: The 4-α-helix topology. J Membrane Biol 120:233-246.
39. Potter NT, Lees MB (1988): Immunochemical characterization of antibodies to the myelin proteolipid protein (PLP). J Neuroimmunol 18:49-60.
40. Potter NT, Stephens TS (1994): Humoral immune recognition of proteolipid protein (PLP) specific encephalitogenic epitopes in the SJL/J mouse. J Neurosci Res 37:15-22.
41. Pratt VM, Boyadjiev S, Dlouhy SR, Silver K, Der Kaloustian VM, Hodes ME (1995): Pelizaeus-Merzbacher disease in a family of Portuguese origin caused by a point mutation in exon 5 of the proteolipid protein gene. Am J Med Genet 55:402-404.
42. Raskind WH, Williams CA, Hudson LD, Bird TD (1991): Complete deletion of the proteolipid protein gene (PLP) in a family with X-linked Pelizaeus-Merzbacher disease. Am J Hum Genet 49:1355-1360.
43. Saugier-Veber P, Munnich A, Bonneau D, Rozet J-M, Le Merrer M, Gil R, Boespflug-Tanguy O (1994): X-linked spastic paraplegia and Pelizaeus-Merzbacher disease are allelic disorders at the proteolipid protein locus. Nat Genet 6:257-352.
44. Schluesener HJ, Sobel RA, Linington C, Weiner H (1987): A monoclonal antibody against a myelin glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J Immunol 139:4016-4021.
45. Schneider A, Montague P, Griffiths I, Fanarraga M, Kennedy P, Brophy P, Nave K-A (1992): Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene. Nature 358:758-761.
46. Seitelberger F (1970): Pelizaeus-Merzbacher disease. In Vinken PJ, Bruyn GW (eds): "Handbook of Clinical Neurology (Leucodystrophies and Poliodystrophies)." Vol 10. Amsterdam: North-Houand, pp 150-202.
47. Sellebjerg FT, Frederiksen JL, Olsson T (1994): Anti-myelin basic protein and anti-proteolipid protein antibody secreting cells in the cerebrospinal fluid of patients with acute optic neuritis. Arch Neurol 51:1032-1036.
48. Shaw SY, Laursen R, Lees MB (1989): Identification of thiol groups and a disulfide crosslink in bovine myelin proteolipid protein. FEBS Lett 250:306-310.
49. Sobel RA, Greer JM, Isaac J, Fondren G, Lees MB (1994): Immunolocalization of proteolipid protein peptide 103-116 in myelin. J Neurosci Res 37:36-43.
50. Stoffel W, Subkowski T, Jander S (1989): Topology of proteolipid protein in the myelin membrane of central nervous system. A study using antipeptide antibodies. Biol Chem Hoppe-Seyler 370:165-176.
51. 223-Pro in the proteolipid protein gene, and prenatal diagnosis. Am J Hum Genet 51:871-878.
52. Sun J-B (1993): Autoreactive T and B cells in nervous system diseases. Acta Neurol Scand 87:5-56.
53. Trifilieff E, Luu B, Nussbaum JL, Roussel G, Espinosa de los Monteros A, Sabatier JM, Van Rietschoten J (1986): A specific immunological probe for the major myelin proteolipid. FEBS J 198:235-239.
54. Trofatter JA, Dlouhy SR, DeMyer W, Conneally PM, Hodes ME (1989): Pelizaeus-Merzbacher disease: Tight linkage to proteolipid protein gene exon variant. Proc Natl Acad Sci USA 86:9427-9430.
55. Warren KG, Catz I (1994a): Relative frequency of autoantibodies to myelin basic protein and proteolipid protein in optic neuritis and multiple sclerosis cerebrospinal fluid. J Neurol Sci 121:66-73.
56. Warren KG, Catz I, Johnson E, Mielke B (1994b): Anti-myelin basic protein and anti-proteolipid protein specific forms of multiple sclerosis. Ann Neurol 35:280-289.
57. Weimbs T, Stoffel W (1992): Proteolipid protein (PLP) of CNS myelin: Positions of free, disulfide-bonded, and fatty acid thioester-linked cysteine residues and implications for the membrane topology of PLP. Biochemistry 31:12289-12296.
58. Yamamura T, Konola JT, Wekerle H, Lees MB (1991): Monoclonal antibodies against myelin proteolipid protein: Identification and characterization of two major determinants. J Neurochem 57:1671-1680.