Analysis of the major histocompatibility complex class I antigen presentation machinery in normal and malignant renal cells: Evidence for deficiencies associated with transformation and progression

Cancer Research

Volumn 56, Issue 8, 1996, Pages 1756-1760

  Seliger, Barbara ^a   Höhne, Alexandra ^a   Knuth, Alexander ^b   Bernhard, Helga ^a   Meyer, Thomas ^d   Tampe, Robert ^d   Momburg, Frank ^c   Huber, Christoph ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b KRANKENHAUS NORDWEST   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d Abteilung fur Somatische Genetik ^*

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CARRIER PROTEIN; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; PROTEASOME; PROTEIN SUBUNIT;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; KIDNEY TUBULE; LYMPH NODE METASTASIS; MALIGNANT TRANSFORMATION; METASTASIS POTENTIAL; PHENOTYPE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTIBODIES; ATP-BINDING CASSETTE TRANSPORTERS; CARCINOMA, RENAL CELL; CELL LINE; EXTRACELLULAR MATRIX PROTEINS; FLOW CYTOMETRY; GENE EXPRESSION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTERFERON TYPE I, RECOMBINANT; KIDNEY; KIDNEY NEOPLASMS; LYMPH NODES; LYMPHATIC METASTASIS; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; OLIGOPEPTIDES; PROTEOGLYCANS; REFERENCE VALUES; TUMOR CELLS, CULTURED;

EID: 0029869243     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Zinkernagel, R. M., and Doherty, P. C MHC restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T cell restriction specificity, function and responsiveness. Adv Immunol., 27: 51-77, 1979.
2. Rotzschke, O., Falk, K., Deres, K., Schild, H., Norda, M., Metzger, J., Jung, D., and Rammensee, H. G Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells Nature (Lond.), 348: 252-254, 1990.
3. Ortiz-Navarette, V., Seelig, A., Gernold, M., Frentzel, S., Kloetzel, J. M , and Hammerling, G. J. Subunit of the "20S" proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex. Nature (Lond), 353: 663-665, 1991.
4. Momburg, F , Ortiz-Navarette, V., Neefjes, J., Goulmy, E , van de Wal, Y., Spits, H , Powis, S. J , Butcher, G W , Howard, J. C., Walden, P , and Hammerling, G J Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation Nature (Lond.), 360: 174-177, 1992
5. Arnold, D., Driscoll, J., Androlewicz, M., Hughes, E. Cresswell, P , and Spies, T Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules Nature (Lond.), 360. 171-174, 1992
6. Trowsdale, J , Hanson, I , Mockridge, I., Beck, S., Townsend, A., and Kelly, A Sequence encoded in the class II region of the MHC related to the "ABC" superfamily of transporters. Nature (Lond), 348: 741-744, 1990.
7. Spies, T , Bresnahan, M., Bahram, S., Arnold, D., Blanck, G., Mellins, E , Pious, D., and DeMars, R. T A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway Nature (Lond.), 348: 744-747, 1990.
8. Attaya, M., Jameson, S., Martinez, C K., Hermel, E., Aldrich, C , Forman, J , Fischer-Lindahl, K., Bevan, M , and Monaco, J. J. Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature (Lond.), 355. 647-649, 1992.
9. Neefjes, J J., Momburg, F., and Hammerling, G. J. Selective and ATP-dependent translocation of peptides by MHC-encoded transporter. Science (Washington DC), 261 769-771, 1993.
10. Schumacher, T N M , Kantesaria, D V., Heemels, M. T., Ashton-Rickardt, P. G.,. Shepherd, J. C., Fruh, K., Young, Y., Peterson, P. A., Tonegawa, S., and Ploegh, H L. Peptide length and sequence specificity of mouse TAP1/TAP2 translocator. J. Exp. Med , 179: 533-540, 1994
11. Cordon-Cardo, C., Fuks, Z., Drobnjak, M., Moreno, C , Eisenbach, L , and Feldmann, M. Expression of HLA-A, B, C antigens in primary and metastatic tumor cell populations of human carcinomas Cancer Res., 54. 6372-6380, 1991.
12. Mausdley, D. J., and Pound, J S. Modulation of MHC antigen expression by viruses and oncogenes. Immunol. Today, 12: 429-431, 1991
13. Ting, J. P. and Baldwin, A. S. Regulation of MHC gene expression Curr Opin. Immunol., 5: 8-16, 1993.
14. Restifo, N. P , Esquivel, F., Kawakami, Y., Yewdell, J. W., Mule, J., Rosenberg, S. A., and Bennink, J. R. Identification of human cancers deficient in antigen processing. J Exp. Med., 177: 265-272, 1993.
15. Cromme, F. V., Airey, J., Heemels, M. T., Ploegh, H. L., Keating, P J., Stern, P. L , Meijer, C L. M , and Walboomers, J M. M Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. J Exp. Med., 179: 335-340, 1994.
16. Sanda, M. G., Restifo, N. P. Walsh, J. C. Kawakami, Y., Nelson, W. G., Pardoll, D. M., and Simons, J W Molecular characterization of defective antigen processing in human prostate cancer. J. Natl Cancer Inst , 87. 280-2285, 1994
17. Rotem-Yeduhar, R., Winograd, S , Sela, S. Coligan, J. E., and Ehrlich, R Down-regulation of peptide transporter genes in cell lines transformed with highly oncogenic adenovirus 12. J. Exp. Med., 180: 477-488, 1994.
18. Epperson, D. E , Arnold, D , Spies, T. Cresswell, P., Pober, J S., and Johnson, D R Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells. J Immunol , 149: 3297-3301, 1992.
19. Seliger, B., Stark, G., and Pfizenmaier, K. Tumor necrosis factor-α affects LTR-controlled oncogene expression in transformed mouse fibroblasts at the posttranscriptional level. J. Immunol , 141: 2138-2144, 1988.
20. Ljunggren, H. G , Stam, N J., Ohlen, C., Neefjes, J J., Höglund, P , Heemels, M. T., Bastin, J., Schumacher, T. N. M., Townsend, A., Karre, K , and Ploegh, H L. Empty MHC class I molecules come out in the cold Nature (Lond.), 346 476-480, 1990.
21. Aulitzky, W. E., Grosse-Wilde, H , Westhoff, U , Tilg, H , Aulitzky, W., Gastl, G., Herold, M., and Huber, C. Enhancement of serum levels of soluble HLA classs I molecules are induced by treatment with recombinant interferon-γ. Clin. Exp. Immunol., 86: 236-239, 1991.
22. Bernhard, H., Karbach, J., Wölfel, T , Busch, P , Storkel, S , Huber, C., Wölfel, C., Seliger, B., Meyer zum Buschenfelde, K. H., and Knuth, A. Cellular immune response to human renal cell carcinomas: definition of a common antigen recognized by HLA-A2 restricted cytotoxic T lymphocyte (CTL) clones. Int. J Cancer, 59: 837-842, 1994