Synthesis and antitumor activity of a new class of water soluble camptothecin derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 6, 1996, Pages 671-674

  Bedeschi, Angelo ^a   Zarini, Franco ^a   Cabri, Walter ^a   Candiani, Ilaria ^a   Penco, Sergio ^a   Capolongo, Laura ^a   Ciomei, Marina ^a   Farao, Mariella ^a   Grandi, Maria ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 AMINOCAMPTOTHECIN; 9 DIMETHYLAMINOMETHYLENEAMINOCAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHIRALITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEUKEMIA; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ANIMALIA;

EID: 0029869163     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00083-2     Document Type: Article

References (15)

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13. 6) δ (ppm) 0.87 (3H, t, J = 7.3 Hz); 1.85 (2H, m); 3.10 (6H, s); 5.27 (2H, s); 5.41 (2H,s); 6.50 (1H, s); 7.08 (1H, m); 7.31 (1H, s); 7.68 (2H, m); 7.94 (1H, s); 9.04 (1H, s). The geometry of the carbon nitrogen double bond was investigated in compound 5f, isolated as free base. NOESY experiments showed that the double bond assumes the E configuration at room temperature. However, treatment with HC1 (0.1M, 1.1 eq, rt) leads to equilibration.
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