α/β-T cell receptor-directed therapy in rat allograft recipients. Long-term survival of cardiac allografts after pretreatment with R73 mAb is associated with upregulation of Th2-type cytokines

Transplantation

Volumn 61, Issue 6, 1996, Pages 948-956

  Heidecke, Claus Dieter ^a   Hancock, Wayne W ^b   Westerholt, Sören ^a   Sewczik, Thomas ^a   Jakobs, Frank ^a   Zantl, Niko ^a   Varzaru, Alexandra ^a   Siegling, Angela ^c   Kurrle, Roland ^d   Deusch, Kai ^a   Volk, Hans Dieter ^c   Kupiec Weglinski, Jerzy W ^e  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b MONASH UNIVERSITY MEDICAL SCHOOL   (Australia)

^c HUMBOLDT UNIVERSITY   (Germany)

^d Behringwerke AG   (Germany)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SURVIVAL TIME; VASCULARIZATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD5; CYTOKINES; DEPRESSION, CHEMICAL; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; LEUKOCYTES; MALE; POLYMERASE CHAIN REACTION; PREOPERATIVE CARE; RATS; RATS, INBRED BN; RATS, INBRED LEW; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TH1 CELLS; TH2 CELLS; TIME FACTORS; UP-REGULATION;

EID: 0029869080     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199603270-00018     Document Type: Article

References (52)

1. Thomson AW. Immunosuppressive drugs and the induction of transplantation tolerance. Transplant Immunol 1994; 2: 263.
2. Masroor STJS, Michler RE, Alexander JW, First MR. Monoclonal antibodies in organ transplantation: an overview. Transplant Immunol 1994; 2: 176.
3. Shizuru JA, Seydel KB, Flavin TF, et al. Induction of donor-specific unresponsiveness to cardiac allografts in rats by pretransplant anti-CD4 monoclonal antibody therapy. Transplantation 1990; 50: 366.
4. Sayegh MH, Kut JP, Milford EL. Anti-CD4 monoclonal antibody effects cellular hyporesponsiveness and prolongs renal allograft survival in the rat. Hum Immunol 1989; 26: 131.
5. Kupiec-Weglinski JW, Diamantstein T, Tilney NL. Interleukin 2 receptor-targeted therapy - rationale and applications in organ transplantation. Transplantation 1988; 46: 785.
6. Hirsch R, Eckhaus M, Auchincloss H, Sachs DH, Bluestone JA. Effects of in vivo administration of an anti-T3 monoclonal antibody on T cell function in mice: I. Immunosuppression of transplantation responses. J Immunol 1988; 140: 3766.
7. Darby CR, Morris PJ, Wood KJ. Evidence that long-term cardiac allograft survival induced by anti-CD4 monoclonal antibody does not require depletion of CD4+ T cells. Transplantation 1992; 54: 483.
8. Gutstein NL, Wofsy D. Administration of F(ab′)2 fragments of monoclonal antibody to L3T4 inhibits humoral immunity in mice without depleting L3T4+ cells. J Immunol 1986; 137: 3414.
9. Tanaka K, Hancock WW, Osawa H, et al. Mechanism of action of anti-IL-2R monoclonal antibodies. ART-18 prolongs cardiac allograft survival in rats by elimination of IL-2R+ mononuclear cells. J Immunol 1989; 143: 2873.
10. Hall BM. Cells mediating allograft rejection. Transplantation 1991; 51: 1141.
11. Yague J, White J, Coleclough C, Kappler J, Palmer E, Marrack P. The T cell receptor: the alpha and beta chains define idiotype, and antigen and MHC specificity. Cell 1985; 42: 81.
12. Hünig T, Wallny HJ, Hartley JK, Lawetzky A, Tiefenthaler G. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation:differential reactivity with subsets of immature and mature T lymphocytes. J Exp Med 1989; 169: 73.
13. Yoshino S, Schlipkoter E, Kinne R, Hünig T, Emmrich F. Suppression and prevention of adjuvant arthritis in rats by a monoclonal antibody to the alpha/beta T cell receptor. Eur J Immunol 1990; 20: 2805.
14. Yoshino S, Cleland LG, Mayrhofer G, Brown RR, Schwab JH. Prevention of chronic erosive streptococcal cell wall-induced arthritis in rats by treatment with a monoclonal antibody against the T cell antigen receptor alpha beta. J Immunol 1991; 146: 4187.
15. Jung S, Kramer S, Schluesener HJ, Hünig T, Toyka K, Hartung HP. Prevention and therapy of experimental autoimmune neuritis by an antibody against T cell receptors-alpha/beta. J Immunol 1992; 148: 3768.
16. Tsuchida M, Hirahara H, Matsumoto Y, Abo T, Eguchi S. Induction of specific unresponsiveness to cardiac allografts by short-term administration of anti-T cell receptor alpha beta antibody. Transplantation 1994; 57: 256.
17. Dufter C, Post S, Thies J, et al. Short-term T cell receptor directed immunotherapy induces organ specific peripheral tolerance in a strongly incompatible rat model. Transplant Immunol 1994; 2: 278.
18. Heidecke CD, Hancock WW, Jakobs F, et al. alpha/beta-TCR-directed therapy in rat cardiac allograft recipients: treatment prior to alloantigen exposure prevents sensitization and abrogates accelerated rejection. Transplantation 1995; 59: 78.
19. van den Bogaerde J, White D, Roser B, Kampinga J, Aspinall R. In vitro and in vivo effects of monoclonal antibodies against T cell subsets on allogeneic and xenogeneic responses in the rat. Transplantation 1990; 50: 915.
20. Hancock WW, Sayegh MH, Sablinski T, Kut JP, Kupiec-Weglinski JW, Milford EL. Blocking of mononuclear cell accumulation, cytokine production, and endothelial activation within rat cardiac allografts by CD4 monoclonal antibody therapy. Transplantation 1992; 53: 1276.
21. Tanaka K, Tilney NL, Stünkel KG, Hancock WW, Diamantstein T, Kupiec-Weglinski JW. Pretreatment with cyclosporine and anti-interleukin 2 receptor antibody abrogates the anti-idiotype response in rat recipients of cardiac allografts. Proc Natl Acad Sci USA 1990; 87: 7375.
22. DiStefano R, Kupiec-Weglinski JW, Uhteg LC, et al. Modulation of accelerated rat cardiac allograft rejection by cyclosporine and ART18. Transplantation Proc 1988; 20 (suppl. 2): 217.
23. Deusch K, Lüling F, Reich K, Classen M, Wagner H, Pfeffer K. A major fraction of human intraepithelial lymphocytes simultaneously expresses the gamma/delta T cell receptor, the CD8 accessory molecule and preferentially uses the V delta 1 gene segment. Eur J Immunol 1991; 21: 1053.
24. Siegling A, Lehmann M, Platzer C, Emmrich F, Volk HD. A novel multispecific competitor fragment for quantitative PCR analysis of cytokine gene expression in rats. J Immunol Methods 1994; 177: 23.
25. Khoury SJ, Hancock WW, Weiner HL. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 1992; 176: 1355.
26. Hancock WW, DiStefano R, Braun P, Schweizer RT, Tilney NL, Kupiec-Weglinski JW. Cyclosporine and anti-interleukin 2 receptor monoclonal antibody therapy suppress accelerated rejection of rat cardiac allografts through different effector mechanisms. Transplantation 1990; 49: 416.
27. Nicolls MR, Aversa GG, Pearce NW, et al. Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody. Transplantation 1993; 55: 459.
28. Ilano AL, Spinelli A, Gurley KE, Strober S, Hall BM. Induction of unresponsiveness to organ allografts: a comparison of different immunosuppressive protocols in DA and WF strains of rats. Transplantation 1991; 51: 905.
29. Yoshino S, Cleland LG. Depletion of alpha/beta T cells by a monoclonal antibody against the alpha/beta T cell receptor suppresses established adjuvant arthritis, but not established collagen-induced arthritis in rats. J Exp Med 1992; 175: 907.
30. Cobbold SP, Jayasuriya A, Nash A, Prospero TD, Waldman H. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 1984; 312: 548.
31. Sablinski T, Sayegh MH, Kut JP, Tilney NL, Milford EL, Kupiec-Weglinski JW. The importance of targeting the CD4+ T cell subset at the time of antigenic challenge for induction of prolonged vascularized allograft survival. Transplantation 1992; 53: 219.
32. Sayegh MH, Sablinski T, Tanaka K, et al. Effects of BWH-4 anti-CD4 monoclonal antibody on rat vascularized cardiac allografts before and after engraftment. Transplantation 1991; 51: 296.
33. Biddison WE, Shaw S. CD4 expression and function in HLA class II-specific T cells. Immunol Rev 1989; 109: 5.
34. Reinherz EL, Meuer S, Fitzgerald KA, Hussey RE, Levine H, Schlossman SF. Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell 1982; 30: 735.
35. Alters SE, Shizuru JA, Ackerman J, Grossman D, Seydel KB, Fathman CG. Anti-CD4 mediates clonal anergy during transplantation tolerance induction. J Exp Med 1991; 173: 491.
36. Mottram PL, Han WR, Purcell LJ, McKenzie IFC, Hancock WW. Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and Interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy. Transplantation 1995; 59: 559.
37. Dallman MJ, Larsen CP, Morris PJ. Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. J Exp Med 1991; 174: 493.
38. Papp I, Wieder KJ, Sablinski T, et al. Evidence for functional heterogeneity of rat CD4+ T cells in vivo: differential expression of IL-2 and IL-4 mRNA in recipients of cardiac allografts. J Immunol 1992; 148: 1308.
39. Siegling A, Lehmann M, Riedel H, et al. A nondepleting anti-rat CD4 monoclonal antibody that suppresses T helper 1-like but not T helper 2-like intragraft lymphokine secretion induces long-term survival of renal allografts. Transplantation 1994; 57: 464.
40. Hancock WW, Sayegh MH, Kwok CA, Weiner HL, Carpenter CB. Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft TH2 cell activation. Transplantation 1993; 55: 1112.
41. Nickerson P, Steurer W, Steiger J, Zheng X, Steele AW, Strom TB. Cytokines and the Th1/Th2 paradigm in transplantation. Curr Opin Immunol 1994; 6: 757.
42. Lee MS, Wogensen L, Shizuru J, Oldstone MB, Sarvetnick N. Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction. J Clin Invest 1994; 93: 1332.
43. Zheng XX, Steele AW, Nickerson PW, Steurer W, Steiger J, Strom TB. Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J Immunol 1995; 154: 5590.
44. Steiger D, Nickerson PW, Steuer W, Moscovitch-Lopatin M, Strom TB. IL-2 knockout recipient mice reject islet cell allografts. J Immunol 1995; 155: 489.
45. Luqman M, Bottomly K. Activation requirements for CD4+ T cells differing in CD45R expression. J Immunol 1992; 149: 2300.
46. Platzer C, Ode HS, Reinke P, Docke WD, Ewert R, Volk HD. Quantitative PCR analysis of cytokine transcription patterns in peripheral mononuclear cells after anti-CD3 rejection therapy using two novel multispecific competitor fragments. Transplantation 1994; 58: 264.
47. Pfeiffer C, Murray J, Madri J, Bottomly K. Selective activation of Th1- and Th2-like cells in vivo - response to human collagen IV. Immunol Rev 1991; 123: 65.
48. Mosmann TR, Moore KW. The role of IL-10 in crossregulation of TH1 and TH2 responses. Immunol Today 1991; 12: A49.
49. Schwartz RH. A cell culture model for T lymphocyte clonal anergy. Science 1990; 248: 1349.
50. Schall TJ, O'Hehir RE, Goeddel DV, Lamb JR. Uncoupling of cytokine mRNA expression and protein secretion during the induction phase of T cell anergy. J Immunol 1992; 148: 381.
51. Dallman MJ, Shiho O, Page TH, Wood KJ, Morris PJ. Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway. J Exp Med 1991; 173: 79.
52. Platzer C, Richter G, Überla K, et al. Analysis of cytokine mRNA levels in interleukin-4-transgenic mice by quantitative polymerase chain reaction. Eur J Immunol 1992; 22: 1179.