Detection of a nuclear antigen 2 (EBNA2)-variant Epstein-Barr virus strain in two siblings with fatal lymphoproliferative disease

Journal of Medical Virology

Volumn 48, Issue 1, 1996, Pages 114-120

  Schuster, Volker ^a   Seidenspinner, Silvia ^a   Kreth, Hans Wolfgang ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

EBER genotype; EBNA2 sequence; EBNA3a sequence; PCR

Indexed keywords

ACICLOVIR; CELL NUCLEUS ANTIGEN; CORTICOSTEROID; CYCLOPHOSPHAMIDE;

ARTICLE; CASE REPORT; EPSTEIN BARR VIRUS; FATALITY; FEMALE; GENETIC ANALYSIS; HEREDITY; HUMAN; LYMPHOPROLIFERATIVE DISEASE; MALE; PRESCHOOL CHILD; SERODIAGNOSIS; SIBLING; VIRUS CHARACTERIZATION; VIRUS INFECTION; VIRUS ISOLATION;

HUMAN HERPESVIRUS 4;

EID: 0029868274     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199601)48:1<114::AID-JMV18>3.0.CO;2-G     Document Type: Article

References (43)

1. Aitken C, Sengupta SK, Aedes C, Moss DJ, Sculley TB (1994): Heterogeneity within the Epstein-Barr virus nuclear antigen 2 gene in different strains of Epstein-Barr virus. Journal of General Virology 75:95-100.
2. Alfieri C, Joncas JH (1987): Biomolecular analysis of a defective non-transforming Epstein-Barr virus (EBV) from a patient with chronic active EBV infection. Journal of Virology 61:3306-3309.
3. Chantier JK, Lund KD, Miki NP, Berkowitz CA, Tai G (1993): Characterization of rubella strain differences associated with attenuation, Intervirology 36:225-236
4. Chen ML, Tsai CN, Liang CL, Shu CH, Hang CR (1992): Cloning and characterization of the latent membrane protein (LMP) of a specific Epstein- Barr virus variant derived from the nasopharyngeal carcinoma in the Taiwanese population. Oncogene 7:2131-2140.
5. Cohen JI, Picchio GR, Mosier DE (1992): Epstein-Barr virus nuclear protein 2 is a critical determinant for tumor growth in SCID mice and for transformation in vitro. Journal of Virology 66:7505-7559.
6. Cohen JI, Wang F, Kieff E (1991): Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation. Journal of Virology 65:2545-2554.
7. Dambaugh T, Hennessy K, Chamnankit L, Kieff E (1984): U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear antigen 2. Proceedings of the National Academy of Sciences, USA 81:7632-7636.
8. de Campos-Lima PO, Gavioli R, Zhang QJ, Wallace LE, Dolcetti R, Rowe M, Rickinson AB, Masucci MG (1993); HLA-A11 epitope loss isolates of Epstein-Barr virus from a highly A11+population. Science 260:98-100.
9. Fleisher G, Starr S, Koven N, Kamiya H, Douglas SD, Henle W (1982): A non-X-linked syndrome with susceptibility to severe Epstein-Barr virus infection. Journal of Pediatrics 100:727-730.
10. Guillot S, Otelea D, Delpeyroux F, Crainic R (1994): Point mutations involved in the attenuation/neurovirulence alternation in type 1 and 2 oral polio vaccine strains detected by site-specific polymerase chain reaction. Vaccine 12:503-507.
11. Hanto DW, Frizzera G, Gajl-Peczalska KJ, Simmons RL (1985): Epstein-Barr virus, immunodeficiency, and B cell lymphoproliferation. Transplantation 39:461-472.
12. Hasegawa K, Huang J, Rogers SA, Blum HE, Liang TJ (1994): Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. Journal of Virology 68:1651-1659.
13. Henle W, Henle G, Andersson J, Ernberg I, Klein G, Horwitz CA, Marklund G, Rymo L, Wellinder C, Straus SE (1987): Antibody responses to Epstein-Barr virus-determined nuclear antigen (EBNA)-1 and EBNA-2 in acute and chronic Epstein-Barr virus infection Proceedings of the National Academy of Sciences, USA 84:570-574.
14. Huang Y, Zhang L, Ho DD (1995): Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection. Journal of Virology 69:93-100.
15. Inaba T, Hanada R, Yaginuma A, Hayashi Y, Kamamoto K, Hukada H (1989): Fatal infectious mononucleosis with staphylococcal pyoderma in a girl with hereditary immunological dysregulations. European Journal of Pediatrics 149:177-178.
16. Jilg W, Sieger E, Alliger P, Wolf H (1990): Identification of type A and B isolates of Epstein-Barr virus by polymerase chain reaction. Journal of Virological Methods 30:319-322.
17. Khanna R, Burrows SR, Kurilla MG, Jacob CA, Misko IS, Sculley TB, Kieff E, Moss DJ (1992): Localisation of Epstein-Barr virus cytotoxic T cell epitopes using recombinant vaccinia: implications for vaccine development. Journal of Experimental Medicine 176:169-178.
18. Kirchhoff F, Greenough TG, Brettler DB, Sullivan JL, Desrosiers RC (1995): Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. New England Journal of Medicine 332:228-232.
19. Knecht H, Bachmann E, Brousset P, Sandvej K, Nadal D, Bachmann F, Odermatt BF, Delsol G, Pallesen G (1993): Deletions within the LMP1 oncogene of Epstein-Barr virus are clustered in Hodgkin's disease and identical to those observed in nasopharyngeal carcinoma. Blood 10:2937-2942.
20. Lee SP (1994): Control mechanisms of Epstein-Barr virus persistence. Seminars in Virology 5:281-288.
21. Lewicki H, Tishon A, Borrow P, Evans CF, Gairin JE, Hahn KM, Jewell DA, Wilson IA, Oldstone MB (1995): CTL escape viral variants. I.Generation and molecular characterization. Virology 210: 29-40.
22. Lin JC, Lin SC, De BK, Chan WP, Evatt BL (1993): Precision of genotyping of Epstein-Barr virus by polymerase chain reaction using three gene loci (EBNA-2, EBNA-3C, and EBER): predominance of type A virus associated with Hodgkin's disease Blood 81:3372-3381.
23. Ling PD, Ryon JJ, Hayward SD (1993): EBNA-2 of herpesvirus Papio diverges significantly from the type A and type B EBNA-2 proteins of Epstein-Barr virus but retains an efficient transactivation domain with a conserved hydrophobic motif. Journal of Virology 67:2990-3003
24. Mroczek EC, Weisenburger DD, Grierson HL, Markin R, Purtilo DT (1987): Fatal infectious mononucleosis and virus-associated hemophagocytic syndrome. Archives of Pathology and Laboratory Medicine 111:530-535.
25. Okano M, Matsumoto S, Osato T, Sakiyama Y, Thiele GM, Purtilo DT (1991): Severe chronic active Epstein-Barr virus infection syndrome. Clinical Microbiology Reviews 4:129-135.
26. Purtilo DT, Cassel CK, Yang JP, Harper R (1975): X-linked recessive progressive combined variable immunodeficiency (Duncan's disease). Lancet 1:935-940.
27. Purtilo DT, Sakamoto K, Saemundsen AK, Sullivan JL, Synnerholm A-C, Anvret M, Pritchard J, Sloper C, Sieff C, Pmcott J, Pachman L, Rich K, Cruzi F, Cornet JA, Collins R, Barnes N, Knight J, Sandstedt B, Klein G (1981): Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases fay clinical, virological, and immunopathological studies. Cancer Research 41:4226-4236.
28. Purtilo DT, Strobach RS, Okano M, Davis JR (1992): Biology of disease: Epstein-Barr virus-associated lymphoproliferative disorders. Laboratory Investigation 67:5-23.
29. Rammensee HG, Friede T, Stefanovic S (1995): MHC ligands and peptide motifs: first listing. Immunogenetics 41:178-228.
30. Sample J, Young L, Martin B, Chatman T, Kieff E, Rickinson A, Kieff E (1990): Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes. Journal of Virology 64:4084-4092.
31. Sandvej K, Peh S-C, Andresen BS, Pallesen G (1994): Identification of potential hot spots in the carboxy-terminal part of the Epstein-Barr virus (EBV) BNLF-1 gene in both malignant and benign EBV-associated diseases: High frequency of a 30-bp deletion in Malaysian and Danish peripheral T-cell lymphomas. Blood 84: 4053-4060.
32. Sanger F, Nicklen S, Coulson A (1977): DNA sequencing with chain terminating inhibitors. Proceedings of the National Academy of Sciences USA 74:5463-5467.
33. Schooley RT, Carey RW, Miller G, Henle W, Eastman R, Mark EJ, Kenyon K, Wheeler EO, Rubin RH (1986): Chronic Epstein-Barr virus infection associated with fever and interstitial pneumonitis. Annals of Internal Medicine 104:636-643.
34. Schuster V, Kreth HW, Müller-Hermelink HK, Huppertz HI, Feller AC, Neumann-Haefelin D, Wiegand H, Müller-Lantzsch N (1990): Epstein-Barr virus infection rapidly progressing to monoclonal lymphoproliferative disease in a child with selective immunodeficiency. European Journal of Pediatrics 150:48-53.
35. Schuster V, Reibnegger G, Wachter H (1992): Neopterin and endogenous Interferon gamma in serum of patients with Epstein-Barr virus-associated lymphoproliferative diseases. Pteridines 2:189-191.
36. Schuster V, Kreß W, Friedrich W, Grimm T, Kreth HW (1993). X-linked lymphoproliferative disease: Detection of a paternally inherited mutation in a German family using haplotype analysis American Journal of Diseases of Children 147:1303-1305.
37. Seemayer TA, Grierson H, Pirruccello SJ, Gross TG, Weisenburger DD, Davis J, Spiegel K, Brichacek B, Sumegi J (1993): X-linked lymphoproliferative disease. American Journal of Diseases of Children 147:1242-1245.
38. Seigneurin JM, Lavoue MF, Genoulaz O, Bornkamm GW, Lenoir GM (1987): Antibody response against the Epstein-Barr virus-coded nuclear antigen 2 (EBNA2) in different groups of individuals. International Journal of Cancer 40:349-353.
39. Sixbey JW, Shirley P, Sloas M, Raab-Traub N, Israele V (1991): A transformation-incompetent, nuclear antigen 2-deleted Epstein-Barr virus associated with replicative infection. Journal of Infectious Diseases 163:1008-1015.
40. Starr SE, Hansen-Flaschen J, Douglas SD, Perussia B (1990): Reappearance of natural-killer cell activity. New England Journal of Medicine 322:133 (letter).
41. Thomson SA, Khanna R, Gardner J, Burrows SR, Coupar B, Moss DJ, Suhrbier A (1995): Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: Implications for vaccine design. Proceedings of the National Academy of Sciences USA 92:0845-5849.
42. Ubol S, Tucker PC, Griffin DE, Hardwick JM (1994): Neurovirulent strains of Alphavirus induce apoptosis in bcl-2-expressing cells: role of a single amino acid change in the E2 glycoprotein. Proceedings of the National Academy of Sciences USA 91:5202-5206.
43. Walling DM, Perkins AG, Webster-Cyriaque J, Resnick L, Raab-Traub N (1994): The Epstein-Barr virus EBNA-2 gene in oral hairy leukoplakia: Strain variation, genetic recombination, and transcriptional expression. Journal of Virology 68:7918-7926.