A second alternative transcript of the gap junction gene connexin32 is expressed in murine Schwann cells and modulated in injured sciatic nerve

European Journal of Cell Biology

Volumn 69, Issue 3, 1996, Pages 267-275

  Söhl, Goran ^a   Gillen, Clemens ^b   Bosse, Frank ^b   Gleichmann, Mark ^b   Müller, Hans Werner ^b   Willecke, Klaus ^a  

^a UNIVERSITY OF BONN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Alernative splicing; Charcot Marie Tooth syndrome CMTX; Connexin diversity; Nerve regneration

Indexed keywords

COMPLEMENTARY DNA; GAP JUNCTION PROTEIN; MESSENGER RNA;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL JUNCTION; CONTROLLED STUDY; DNA LIBRARY; EXON; INTRON; LIVER; MALE; MOLECULAR CLONING; MOUSE; NERVE INJURY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RAT; SCHWANN CELL; SCIATIC NERVE; STEM CELL; TISSUE DISTRIBUTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 0029867989     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Bai, S., A. Schoenfeld, A. Pietrangelo, R. D. Burk: Basal promoter of the rat connexin32 gene: identification and characterization of an essential element and its DNA binding protein. Mol. Cell. Biol. 15, 1439-1445 (1995).
2. Bai, S., D. C. Spray, R. D. Burk: Identification of proximal and distal regulatory elements of the rat connexin32 gene. Biochim. Biophys. Acta 1216, 197-204 (1993).
3. Bennett, M. V. L., L. C. Barrio, T. A. Bargiello, D. C. Spray, E. Hertzberg, J. C. Saez: Gap Junctions: new tools, new answers. new questions. Neuron 6, 305-320 (1991).
4. Bergoffen, J., S. S. Scherer, S. Wang, M. O. Scott, L. J. Bone, D. L. Paul, K. Chen, M. W. Lensch, P. F. Chance, K. H. Fischbeck: Connexin mutations in X-linked Charcot-Marie-Tooth disease. Science 262, 2039-2042 (1993).
5. Beyer, E. .: Gap junctions. Int. Rev. Cytol. 137c, 1-37 (1993).
6. Bosse, F., G. Zoidl, S. Wilms, C. P. Gillen, H. G. Kuhn, H. W. Müller: Differential expression of two mRNA species indicates a dual function of peripheral myelin protein PMP22 in cell growth and myelination. J. Neurosci. Res. 37, 529-537 (1994).
7. Brockes, J. P., K. L. Fields, M. C. Raff: Studies on cultured Schwann cells. I. Derivation of purified populations from cultures of peripheral nerve. Brain Res. 165, 105-118 (1979).
8. Bruzzone, R., J. A. Haefliger, R. L. Gimlich, D. L. Paul: Connexin40, a component of gap junctions in vascular endothel is restricted in its ability to interact with other connexins. Mol. Biol. Cell 4, 7-20 (1993).
9. Carmichael, G. G.: Molecular weight determinations of RNA by gel electrophoresis. Electrophoresis 1, 78-92 (1980).
10. Chomczynski, P., N. Sacchi: Single step method of RNA isolation by acid guanidinium-thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159 (1987).
11. Dahl, E., H. Hennemann, G. Hallas, U. Dahl, K. Willecke: Alternative promoters regulate expression of the gap junction gene connexin32 in mouse embryonic stem cells and mouse liver. Submitted for publication (1995).
12. Elfgang, C., R. Eckert, H. Lichtenberg-Fraté, A. Butterweck, O. Traub, R. A. Klein, D. Hülser, K. Willecke: Specific permeability and selective formation of gap junction channels in connexin transfected HeLa cells. J. Cell Biol. 129, 805-817 (1995).
13. Fairweather, N., C. Bell, S. Cochrane, J. Chelly, S. Wang, M. L. Mostaccinolo, A. P. Monaco, N. E. Haites: Mutations in the connexin32 gene in X-linked dominant Charcot-Marie-Tooth disease (CMTX). Human Mol. Genetics 3, 29-34 (1994).
14. Haeflinger, J.-A., R. Bruzzone, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, D. L. Paul: Four novel members of the connexin family of gap junction proteins. J. Biol. Chem. 267, 2057-2064 (1992).
15. Hennemann, H., G. Kozjek, E. Dahl, B. Nicholson, K. Willecke: Molecular cloning of mouse connexins26 and -32: similar genomic organization but distinct promoter sequences of two gap junction genes Eur. J. Cell Biol. 58, 81-89 (1992).
16. Herget, T., M. Burba, M. Schmoll, K. Zimmermann, A. Starzinsky-Powitz: Regulated expression of nuclear proteins in myogenic cells that binds to a conversed 3' untranslated region in pro α 1 (I) collagen cDNA. Mol. Cell. Biol. 9, 2828-2836 (1989).
17. Ionasescu, V., C. Searby, R. Ionasescu: Point mutations of the connexin32 (GJB1) gene in X-linked dominant Charcot-Marie-Tooth neuropathy. Human Mol. Genetics 3, 355-358 (1994).
18. Klemm, J. D., M. A. Rould, R. Aurora, W. Herr, C. O. Pabo: Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. Cell 77, 21-32 (1994)
19. Krislensen, T., H. Voss, C. Schwager, J. Stegemann, B. Sproat, W. Ansorge. T7 polymerase in automated dideoxy sequencing. Nucleic Acids Res. 16, 3487-3496 (1988).
20. Lehrach, H., D. Diamond, J. M. Wosney, H. Boedtker: RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry 16, 4743-4751 (1977).
21. Maniatis, T., E. F. Fritsch, J. Sambrook: Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory. Cold Spring Harbor. NY 1989.
22. Miller, T., G. Dahl, R. Werner: Structure of a gap junction gene: rat connexin32. Biosci. Rep. 8, 455-464 (1988).
23. Muller, H. W., M. J. Ignatius, D. H. Hangen. E. M. Shooter: Expression of specific sheath cell proteins during peripheral nerve growth and regeneration in mammals. J. Cell Biol. 102, 393-402 (1986).
24. Neuhaus, I. M., G. Dahl, R. Werner: Use of alternate promoters for tissue specific expression of the gene coding for connexin32. Gene 158, 257-262 (1995).
25. Patel, P. I., J. R. Lupski: Charcot-Marie-Tooth disease: a new paradigm for the mechanism of inherited disease. Trends Genet. 4, 128-133 (1994).
26. Paul, D. L.: Molecular cloning of cDNA for rat liver gap junction protein. J. Cell Biol. 103, 123-134 (1986).
27. Porter, S., M. B. Clark, L. Glaser, R. P. Bunge: Schwann cells stimulated to proliferate in the absence of neurons retain full functional capacity. J. Neurosci. 6, 3070-3078 (1986).
28. Sato-Bigbee, C., E. L. P. Chan, R. K. Yu: Oligodendroglial cAMP response element binding protein. A member of the CREB family of transcription factors. J. Neurosci. Res. 38, 621-628 (1994).
29. Scherer, S. S., D.-Y. Wang, R. Kuhn, G. Lemke, L. Wrabetz, J. Kamholz: Axons regulate Schwann ceil expression of the POU transcription factor SCIP. J. Neurosci. 14, 1930-1942 (1994).
30. Snipes, G. J., U. Suter: Signalling pathways mediating axon - Schwann cell interactions. Trends Neurosci. 17, 399-401 (1994).
31. Steinberg, T. H., R. Civitelli, S. T. Geist, A. J. Robertson, E. Hick, R. D. Veenstra, H. Z. Wang, P. M. Marlow, E. M. Westphale, J. Laing, E. C. Beyer: Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells. EMBO J. 4, 744-750 (1994).
32. Stürzl, M., W. K. Roth, P. Viehweger, P. Hofschneider: Taq DNA-polymerase synthesized single stranded DNA-hybridization and their application in Northern blotting and in situ hybridization. In: A. Rolfs, H. C. Schumacher, P. Marx (eds.). PCR Topics. Usage of Polymerase chain Reaction in Genetic and Infectious Diseases. pp. 41-45. Springer-Verlag, Berlin 1991.
33. Stutenkemper, R., S. Geisse, J. Look, O. Traub, B. J. Nicholson, K. Willecke: The hepatocyte specific phenotype in murine liver correlates with high expression of connexin32 and -26, but very low expression of connexin43. Exp. Cell Res. 201, 43-54 (1992).
34. Sullivan, R., C. Ruangvoravat, D. Joo, J. Morgan, B. L. Wang, X. K. J. Wang, C. W. Lo: Structure, sequence and expression of the mouse Cx43 gene encoding connexin43. Gene 130, 191-199 (1993).
35. Veenstra, R. D., H. Z. Wang, E. Beyer, P. Brink: Selective dye and ionic permeability of gap junction channels formed by connexin45. Circ. Res. 75, 483-490 (1994).
36. Veenstra, R. D., H. Z. Wang, E. G. Beyer, S. V. Ramanan, R. P. Brink: Connexin37 forms high conductance gap junction channels with subconductance state activity and selective dye and ionic permeabilities. Biophys. J. 66, 1915-1928 (1994).
37. White, T. W., R. Bruzzone, D. A. Goodenough, D. L. Paul: Mouse Cx50, a functional member of the connexin family of gap junction proteins is the lens fiber protein MP70. Mol. Biol. Cell 3, 711-720 (1992).
38. Willecke, K., H. Hennemann, E. Dahl, S. Jungbluth, R. Heynkes: The diversity of connexin genes encoding gap junctional proteins. Eur. J. Cell Biol. 56, 1-7 (1991).
39. Yu, W., G. Dahl, R. Werner: The connexin43 gene is responsive to estrogen. Proc. R. Soc. London B 255, 125-132 (1994).