The amiloride inhibitable Na+ conductance of rat colonic crypt cells is suppressed by forskolin

Pflugers Archiv European Journal of Physiology

Volumn 431, Issue 6, 1996, Pages 984-986

  Ecke, D ^b   Bleich, M ^b   Greger, R ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b NONE

Author keywords

cAMP; Cl channel; Cl secretion; Colon; Exocrine secretion; Na+ absorption; Na+ channel

Indexed keywords

AMILORIDE; CORTICOSTEROID; CYCLIC AMP; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE INHIBITOR; SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CHLORIDE CONDUCTANCE; COLON; CONTROLLED STUDY; CRYPT CELL; EXOCRINE SECRETION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SODIUM CONDUCTANCE;

1-METHYL-3-ISOBUTYLXANTHINE; AMILORIDE; ANIMALS; CHLORIDE CHANNELS; CHLORIDES; COLON; DOWN-REGULATION; ELECTRIC CONDUCTIVITY; FORSKOLIN; ION TRANSPORT; MEMBRANE POTENTIALS; RATS; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 0029867813     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050095     Document Type: Article

References (13)

1. Anderson MP, Gregory RJ, Thompson S, Souza DW, Paul S, Mulligan RC, Smith AE, Welsh MJ (1991) Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science 253:202-205
2. + channel is made of three homologous subunits. Nature 367:463-467
3. Cunningham SA, Frizzell RA, Morris AP (1995) Vesicular targeting and the control of ion secretion in epithelial cells: implications for cystic fibrosis. J Physiol (Lon) 482.P:27S-30S
4. - secretion in rat and rabbit colon. Cell Physiol Biochem 5:204-210
5. Ecke D, Bleich M, Schwartz B, Fraser G, Greger R (1995) The ion conductances of colonic crypts from dexamethasone-treated rats. Pfluegers Arch Eur J Physiol 431:419-426
6. Fuller CM, Benos DJ (1992) CFTR! Am J Physiol 267:C267-C287
7. - conductance. FEBS Lett 374:312-316
8. Hug T, Koslowsky T, Ecke D, Greger R, Kunzelmann K (1995) Actin-dependent activation of ion conductances in bronchial epithelial cells. Pfluegers Arch Eur J Physiol 429:682-690
9. 29 colon carcinoma cells. Pfluegers Arch Eur J Physiol 430:653-665
10. + channels in Xenopus oocytes. FEBS Lett in press
11. + conductance. Pfluegers Arch Eur J Physiol submitted
12. Riordan JR, Rommens JM, Kerem B-S, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N, Chou J-L, Drumm ML, Iannuzzi MC, Collins FS, Tsui L-C (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245:1066-1073
13. Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn JA, Rossier BC, Boucher RC (1995) CFTR as a cAMP-dependent regulator of sodium channels. Science 269:847-850