Inhibition of avian myeloblastosis virus reverse transcriptase by an alkaloid purified from Peschiera campestris

Phytotherapy Research

Volumn 10, Issue 2, 1996, Pages 113-116

  Juca M B ^a   Aoyama, H ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Alkaloid; Inhibition; Reverse transcriptase

Indexed keywords

12 METHOXY NB METHYLVOACHALOTINE; ALKALOID; DNA; MANGANESE; PESCHIERA CAMPESTRIS EXTRACT; PLANT EXTRACT; POLY(2' FLUOROADENYLIC ACID); POLYADENYLIC ACID; POLYCYTIDYLIC ACID; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; AVIAN MYELOBLASTOSIS VIRUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG PURIFICATION; ENZYME INHIBITION; NONHUMAN;

EID: 0029867702     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1573(199603)10:2<113::AID-PTR781>3.0.CO;2-B     Document Type: Article

References (24)

1. Aoyama, H. (1991). Avian myeloblastosis virus reverse transcriptase inhibition by nalidixic acid. Mol. Cell. Biochem. 108, 169-174.
2. Aoyama, H., Sarih-Cottin, L., Tarrago-Litvak, L., Kakiuchi, N., Litvak, S., and Gushlbauer, W. (1985). 2′-fluoro-2′-deoxy-polynucleotides as templates and inhibitors for RNA- and DNA-dependent DNA polymerases. Biochim. Biophys. Acta 824, 225-232.
3. Aposhian, H. V., and Kornberg, A. (1962). Enzymatic synthesis of DNA. IX. The polymerase formed after T2 bacteriophage infection of E. coli: a new enzyme. J. Biol. Chem. 237, 519-524.
4. Baltimore, D., and Smoler, D. (1971). Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses. Proc. Natl. Acad. Sci. USA 68, 1507-1511.
5. Chu, S. C., Hsieh, Y. S., and Lin, J. Y. (1992). Inhibitory effects of flavonoids on Moloney murine leukemia virus reverse transcriptase. J. Nat. Prod. 55, 179-183.
6. Duesberg, P., Helm, K. V. D., and Canaani, E. (1971). Comparative properties of RNA and DNA templates for the DNA polymerase of Rous sarcoma virus. Proc. Natl. Acad. Sci. USA 68, 2505-2509.
7. Gerard, G. F. (1983). Reverse transcriptase. In, Enzymes of Nucleic Acid Synthesis and Modification, ed. by S. T. Jacob. Vol. 1, pp. 1-38. CRC Press, Boca Raton, Florida.
8. Gower, A. E., Pereira, B. S., and Marsaioli, A. J. (1986). Indole alkaloids from Peschiera campestris. Phytochemistry 25, 2908-2910.
9. Hegnauer, P. (1988). Biochemistry, distribution and taxonomic relevance of higher plant alkaloids. Phytochemistry 27, 2423-2427.
10. Kakiuchi, N., Hattori, M., Ishii, H., and Namba, T. (1987). Effect of benzo[c]phenanthridine alkaloids on reverse transcriptase and their binding properties to nucleic acids. Planta Med 53, 22-27.
11. Kakiuchi, N., Hattori, M., Namba, T., Nishizawa, M., Yamagishi, T., and Okuda, T. (1985). Inhibitory effect of tannins on reverse transcriptase from RNA tumor virus. J. Nat. Prod. 48, 614-626.
12. Kusumoto, I. T., Shimada, I., Kakiuchi, N., Hattori, M., Namba, T., and Supriyatna, S. (1992). Inhibitory effects of Indonesian plant extracts on reserve transcriptase of an RNA tumour virus (I). Phytother. Res. 6, 241-244.
13. Lau, A. F., Siedlecki, J., Anleitner, J., Patterson, G. M. L., Caplan, F. R., and Moore, R. E. (1993). Inhibition of reverse transcriptase activity by extracts of cultured blue-green algae (Cyanophyta). Planta Med. 59, 148-151.
14. Loya, S., and Hizi, A. (1990). The inhibition of human immunodeficiency virus type 1 reverse transcriptase by avarol and avarone derivatives. FEBS Lett 269, 131-134.
15. Loya, S., Rudi, A., Tal, R., Kashman, Y., Loya, Y., and Hizi, A. (1994). 3,5,8-Trihydroxy-4-quinolone, a novel natural inhibitor of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2. Arch. Biochem. Biophys. 309, 315-322.
16. Nakane, H., and Ono, K. (1990). Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases. Biochemistry 29, 2841-2845.
17. Ono, K., Nakane, H., Fukushima, M., Chermann, J. C., and Barré-Sinoussi, F. (1990). Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. Eur. J. Biochem. 190, 469-476.
18. Papas, T. S., Sandhaus, L., Chirigos, M. A., and Furusawa, E. (1973). Inhibition of DNA polymerase of avian myeloblastosis virus by an alkaloid extract from Narcissus tarzetta L. Biochem. Biophys. Res. Commun. 52, 88-92.
19. Sethi, M. L. (1985). Comparison of inhibition of reverse transcriptase and antileukemic activities exhibited by protoberberine and benzophenanthridine alkaloids and structure-activity relationship. Phytochemistry 24, 447-454.
20. Sethi, V. S. (1976). Inhibition of mammalian and on cornavirus nucleic acid polymerase activities by alkoxybenzophenanthridine alkaloids. Cancer Res. 36, 2390-2395.
21. Sethi, V. S., and Sethi, M. L. (1975). Inhibition of reverse transcriptase activity of RNA-tumor viruses by fagaronine. Biochem. Biophys. Res. Commun. 63, 1070-1076.
22. Tambly, T. M., and Wells, R. D. (1975). Comparative ability of RNA and DNA to prime DNA synthesis in vitro: role of sequence, sugar, and structure of template-primer Biochemistry 14, 1412-1425.
23. Torsell, K. B. G. (1983). Natural Product Chemistry. A Mechanism and Biosynthetic Approach to Secondary Metabolism. John Wiley & Sons, New York.
24. Weber, J. (1993). The molecular basis of antiretroviral therapy. J. Antimicrob. Chemother. 32, 789-791.