Fecal hemoglobin excretion in elderly patients with atrial fibrillation: Combined aspirin and low-dose warfarin vs conventional warfarin therapy

Archives of Internal Medicine

Volumn 156, Issue 6, 1996, Pages 658-660

  Blackshear, Joseph L ^a   Baker, Vickie S ^a   Holland, Anne ^b   Litin, Scott C ^b   Ahlquist, David A ^b   Hart, Robert G ^c   Ellefson, Ralph ^b   Koehler, Jodi ^d  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d Stat and Epidemiol Res Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; WARFARIN;

AGED; ARTICLE; DISEASE ASSOCIATION; DISEASE CONTROL; DOSE RESPONSE; ELDERLY CARE; FOLLOW UP; GASTROINTESTINAL HEMORRHAGE; HEART ATRIUM FIBRILLATION; HEMOGLOBIN ANALYSIS; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RISK ASSESSMENT; STATISTICAL ANALYSIS; STROKE;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; ASPIRIN; ATRIAL FIBRILLATION; DRUG THERAPY, COMBINATION; FECES; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; THROMBOSIS; WARFARIN;

EID: 0029867488     PISSN: 00039926     EISSN: None     Source Type: Journal    
DOI: 10.1001/archinte.156.6.658     Document Type: Article

References (16)

1. Becker RC, Ansell J. Antithrombotic therapy: an abbreviated reference for clinicians. Arch Intern Med. 1955;155:149-161.
2. Levine MN, Hirsh J, Landefeld S, Raskob G. Hemorrhagic complications of anticoagulant treatment. Chest. 1992;102:352S-363S.
3. Stein PD, Alpert JS, Copeland J, Dalen JE, Goldman S, Turpie AGG. Antithrombotic therapy in patients with mechanical and biological prosthetic heart valves. Chest. 1992,102:445S-455S.
4. Meade TW, Howarth DJ, Brennan PJ. Effects of low intensity antithrombotic regimes on the haemoglobin level. Thromb Haemost. 1994;71:284-285.
5. Landefeld CS, Goldman L. Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy. Am J Med. 1989,87:144-152.
6. Landefeld CS, Rosenblatt MW, Goldman L. Bleeding in outpatients treated with warfarin: relation to the prothrombin time and important remediable lesions Am J Med. 1989;87:153-159
7. Second Report of the Sixty Plus Reinfarction Study Research Group. Risks of long-term oral anticoagulant therapy in elderly patients after myocardial infarction. Lancet. 1982;1:64-68
8. Forfar JC. Prediction of hemorrhage during long-term oral coumarin anticoagulation by excessive prothrombin ratio. Am Heart J. 1982;103:445-446.
9. Hylek EM, Singer DE. Risk factors for intracranial hemorrhage in outpatients taking warfarin. Ann Intern Med. 1994;120:897-902.
10. Schwartz S, Dahl J, Ellefson M, Ahlquist DA. The HemoQuant test: a specific and quantitative determination of heme (hemoglobin) in feces and other materials. Clin Chem. 1983;29:2061-2067.
11. Ahlquist DA, Wiand HS, Moertel CG, et al. Accuracy of fecal occult blood screening for colorectal neoplasia: a prospective study using Hemoccult and HemoQuant. JAMA. 1993;269:1262-1267
12. Major Ongoing Stroke Trials Stroke. 1994;25:2112-2116.
13. Turpie AGG, Gent M, Laupacis A, et al. A comparison of aspirin with placebo in patients treated with warfarin after heart-valve replacement. N Engl J Med. 1993;329:524-529.
14. Benjamin EJ, Levy D, Vaziri SM, D'Agostino RB, Belanger AJ, Wolf PA Independent risk factors for atrial fibrillation in a population-based cohort: The Framingham Heart Study. JAMA. 1994;271:840-844.
15. Atrial Fibrillation investigators. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials. Arch Intern Med. 1994,154:1449-1457.
16. Wolf PA, Lewis A. Conner Lecture: contributions of epidemiology to the prevention of stroke. Circulation. 1993;88:2471-2478