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Volumn 122, Issue 4, 1996, Pages 254-256

Designing of chimeric DNA/RNA hammerhead ribozymes to be targeted against AML1/MTG8 mRNA

Author keywords

Acute myeloid leukemia; Gene therapy; Ribozyme

Indexed keywords

RIBOZYME;

EID: 0029867415     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01209655     Document Type: Article
Times cited : (12)

References (13)
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  • 3
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    • Junctions of the AML1/MTG8(ETO) fusion are constant in t(8:21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction
    • Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, Asou H, Kamada N, Ohki M (1993) Junctions of the AML1/MTG8(ETO) fusion are constant in t(8:21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. Blood 82: 1270-1276
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  • 5
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    • Ribozymes cleave the AML1/MTG8 fusion transcript and inhibit proliferation of leukemic cells with t(8;21)
    • Matsushita H, Kobayashi H, Mori S, Kizaki M, Ikeda Y (1995) Ribozymes cleave the AML1/MTG8 fusion transcript and inhibit proliferation of leukemic cells with t(8;21). Biochem Biophys Res Commun 215: 431-437
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  • 6
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    • Mitelman, F.1    Kaneko, Y.2    Berger, R.3
  • 7
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    • t(8;21) Breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
    • Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M (1991) t(8;21) Breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci USA 88: 10431-10434
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10431-10434
    • Miyoshi, H.1    Shimizu, K.2    Kozu, T.3    Maseki, N.4    Kaneko, Y.5    Ohki, M.6
  • 8
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    • The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
    • Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M (1993) The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J 12: 2715-2721
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  • 9
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    • A ribozyme which discriminates in vitro between PML/RARα, the t(15;17)-associated fusion RNA of acute promyelocytic leukemia, and PML and RARα, the transcripts from the nonrearranged alleles
    • Pace U, Bookman JM, Mackay BJ, Wilson H, Miller J, Dimitrovsky E, Goldberg AR (1994) A ribozyme which discriminates in vitro between PML/RARα, the t(15;17)-associated fusion RNA of acute promyelocytic leukemia, and PML and RARα, the transcripts from the nonrearranged alleles. Cancer Res 54: 6365-6369
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  • 10
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  • 12
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    • Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.