Validation of automated behavioral test systems

Neurotoxicology and Teratology

Volumn 18, Issue 2, 1996, Pages 189-197

  Henck, Judith W ^a   Frahm, Denise Traxler ^a   Anderson, John A ^a  

^a PFIZER INC   (United States)

Author keywords

Automated behavioral test battery; Developmental neurotoxicity; Diazepam; Methimazole; Rat; Validation

Indexed keywords

DIAZEPAM; THIAMAZOLE;

ADOLESCENT; ANIMAL EXPERIMENT; ARTICLE; AUTOMATION; AVOIDANCE BEHAVIOR; BEHAVIOR; CONTROLLED STUDY; FEMALE; MALE; NEUROTOXICITY; NEWBORN; NONHUMAN; ORAL DRUG ADMINISTRATION; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; STARTLE REFLEX; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA;

EID: 0029867336     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/0892-0362(95)02058-6     Document Type: Article

References (24)

1. Albee, R. R.; Mattsson, J. L. Neurophysiological effects of perinatal methimazole administration: A positive control study. Toxicologist 8:227; 1988.
2. Brabham, T. K.; Henck, J. W.; Anderson, J. A. Modification of the acoustic startle response in rats by amphetamine, ethanol and gentamicin. Toxicologist 14:96; 1994.
3. Buelke-Sam, J.; Kimmel, C. A. Development and standardization of screening methods for behavioral teratology. Teratology 20: 17-30; 1979.
4. Comer, C. P.; Norton, S. Effects of perinatal methimazole exposure on a developmental test battery for neurobehavioral toxicity in rats. Toxicol. Appl. Pharmacol. 63:133-141; 1982.
5. De Salvia, M. A.; Cagiano, R.; Lacomba, C.; Cuomo, V. Neurobehavioral changes produced by developmental exposure to benzodiazepines. Dev. Pharmacol. Ther. 15:173-177; 1990.
6. Frieder, B.; Epstein, S.; Grimm, V. E. The effects of exposure to diazepam during various stages of gestation or during lactation on the development and behavior of rat pups. Psychopharmacology (Berlin) 83:51-55; 1984.
7. Gad, S.; Weil, C. S. Statistics and experimental design for toxicologists. Caldwell, NJ: The Telford Press; 1986:72-73.
8. Greenhouse, S. W.; Geisser, S. On methods in the analysis of profile data. Psychometrika 32:95-112; 1959.
9. Henck, J. W.; Traxler Frahm, D.; Pelton, R.; Anderson, J. A. Validation of an automated activity monitor system using d-amphetamine and phenobarbital. Neurotoxicol. Teratol. 16:324; 1994.
10. International Conference on Harmonisation: Guideline on detection of toxicity to reproduction for medicinal products. Fed. Reg. 59(183):48746-48753; 1994.
11. Johnson, R. A.; Wichern, D. W. Applied multivariate statistical analysis. New York: Prentice-Hall; 1982.
12. Kellogg, C. K.; Chisholm, J.; Simmons, R. D.; Ison, J. R.; Miller, R. K. Neural and behavioral consequences of prenatal exposure to diazepam. Monogr. Neural Sci. 9:119-129; 1983.
13. Kellogg, C. K.; Simmons, R. D.; Miller, R. K.; Ison, J. R. Prenatal diazepam exposure in rats: Long-lasting functional changes in the offspring. Neurobehav. Toxicol. Teratol. 7:438-488; 1985.
14. Kosazuma, T.; Kobayashi, Y.; Shiota, S.; Suzuki, M.; Inomata, N.; Akahori, A. Summary of the survey on behavioral teratology study in Japanese pharmaceutical industries. Cong. Anom. 22: 111-125; 1982.
15. 2O. Teratology 39:508; 1989.
16. Ryan, C. L.; Pappas, B. A. Intrauterine diazepam exposure: Effects on physical and neurobehavioral development in the rat. Neurobehav. Toxicol. Teratol. 8:279-286; 1986.
17. SAS/STAT user's guide, volume 2, GLM-Varcomp, version 6, 4th ed. Cary, NC: SAS Institute; 1990.
18. Schneider, B. F.; Golden, W. L. Perinatal hypothyroidism and neurologic development in rats: A dose-response study with methimazole. Teratology 31:64A; 1985.
19. Shibuya, T.; Watanabe, Y.; Hill, H. F.; Salafsky, B. Developmental alterations in maturing rats caused by chronic prenatal and postnatal diazepam treatments. Jpn. J. Pharmacol. 40:21-29; 1986.
20. Szakacs, N. A.; Halladay, S. C. Behavioral assessment of rats treated perinatally with methimazole: Industrial application of the test battery. Teratology 27:79A; 1983.
21. Tachibana, T. A critical view of the utility of positive controls in a test battery. Neurobehav. Toxicol. Teratol. 6:155-159; 1984.
22. Tukey, J. W.; Ciminera, J. L., Heyse, J. F. Testing the statistical certainty of a response to increasing doses of a drug. Biometrics 41:295-301; 1985.
23. Weisenburger, W. P.; Keller, K. A.; Schardein, J. L. Perinatal methimazole exposure in the rat: Validation of a developmental neurobehavioral battery. Teratology 43:498; 1991.
24. Wilcoxon F. Individual comparisons by ranking methods. Biometrics 1:80-93; 1945.