Differential susceptibility to neurofibrillary pathology among patients with down syndrome

Dementia and Geriatric Cognitive Disorders

Volumn 7, Issue 3, 1996, Pages 135-141

  Wegiel, J ^a   Wisniewski, H M ^a   Dziewiatkowski, J ^b   Popovitch, E R ^a   Tarnawski, M ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Alzheimer disease; Down syndrome; Morphometry; Neurofibrillary changes; Plaques

Indexed keywords

MONOCLONAL ANTIBODY;

ADOLESCENT; ADULT; AGE; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; CLINICAL ARTICLE; CLUSTER ANALYSIS; DENSITY; DISEASE PREDISPOSITION; DISEASE SEVERITY; DOWN SYNDROME; HUMAN; HUMAN TISSUE; NERVE CELL; NEUROFIBRILLARY TANGLE; ONSET AGE; PRIORITY JOURNAL; RISK; SENILE PLAQUE;

ADOLESCENT; ADULT; AGED; ALZHEIMER DISEASE; ANTIBODIES, MONOCLONAL; BIOLOGICAL MARKERS; DISEASE SUSCEPTIBILITY; DOWN SYNDROME; HUMANS; MIDDLE AGED; NEUROFIBRILLARY TANGLES; NEUROFIBRILS;

EID: 0029867086     PISSN: 14208008     EISSN: 14219824     Source Type: Journal    
DOI: 10.1159/000106868     Document Type: Article

References (32)

1. Rumble B, Retallack R, Hilbich C, Simms G, Multhaup G, Martins R, Hockey A, Montgomery P, Beyrcuther K, Masters CL: Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer’s disease. N Engl J Med 1989: 320:1446-1452.
2. Beyreuther K, Pollwcin P, Multhaup G, Mönning U, König G, Dyrks T, Schubert G, Masters CL: Regulation and expression of the Alzheimer's β/A4 amyloid protein precursor in health, disease, and Down’s syndrome. Ann NY Acad Sci 1993:695:91-102.
3. Mann DMA, Esiri MM: The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syn-romc. J Neurol Sci 1989:89:169-179.
4. Wisniewski KE, Wisniewski HM, Wen GY: Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 1985:17:278-282.
5. Wisniewski HM, Wegiel J, Popovitch ER: Age-associated development of diffuse and thioflavine-S-positive plaques in Down syndrome. Dev Brain Dysfunct 1995:7:330-339.
6. Burger PC, Vogel FS: The development of the pathologic changes of Alzheimer’s disease and senile dementia in patients with Down's synrome. Am J Pathol 1973;73:457-476.
7. Mann DMA: The pathological association between Down syndrome and Alzheimer disease. Mcch Ageing Dev 1988;43:99-136.
8. Allsop D, Haga S-L, Haga C, Ikeda S-I, Mann DMA, Ishii T: Early senile plaques in Down’s syndrome brains show a close relationship with cell bodies of neurons. Neuropathol Appl Neurobiol 1989;15:531-542.
9. Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA: Multiple isoforms of human microtubulc-associated protein tau: Sequences and localization in neurofibrillary' tangles of Alzheimer’s disease. Neuron 1989;3: 519-526.
10. Perry G, Muivihill P, Fried VA, Smith HT, Grundke-Iqbal I, Iqbal K: Immunochemical properties of ubiquitin conjugates in the paired helical filaments of Alzheimer disease. J Ncu-rochem 1989;52:1523-1528.
11. Bancher C, Brunner C, Lassmann H, Budka H, Jellinger K, Wiche G, Scitelberger F, Grundke-Iqbal I, Iqbal K, Wisniewski HM: Accumulation of abnormally phosphorylated x precedes the formation of neurofibrillary tangles in Alzheimer’s disease. Brain Res 1989:477:90-99.
12. Zar JH: Biostatistical analysis. Englewood Cliffs. Prentice Hall. 1984.
13. McQuaid S, Allen IV, McMahon J, Kirk J: Association of measles virus with neurofibrillary tangles in subacute sclerosing panencephalitis: A combined in situ hybridization and im-munociochcmical investigation. Neuropathol Appi Neurobiol 1994;20:103-110.
14. Wisniewski HM, Dymecki J, Wegiel J, Kulczycki J, Schmidt-Sidor B, Grundke-Iqbal I, Slrojny P: Neurofibrillary pathology in subacute sclerosing panencephalitis. Dementia 1991;2:133-141.
15. Barcikowska M, Wisniewski HM, Bancher C, Grundke-Iqbal I: About the presence of paired helical filaments in dystrophic neuntes participating in the plaque formation. Acta Neuropatici (Beri) 1989;78:225-231.
16. Wisniewski HM, Popovitch ER, Kaufmann MA, Wisniewski KE: Neurofibrillary changes in advanced hydrocephalus. A clinicopatliolog-ical study. J Neuropathol Exp Neurol 1987:46: 340.
17. Wisniewski HM, Constantinidis J, Wegiel J, Bobinski M, Tamawski M: Neurofibrillary pathology in brains of elderly schiozophrenics treated with neuroleptics. Alzheimer Dis Assoc Disord 1994:8:211-227.
18. Evans DA, Funkenstein HH, Albert MS, Schcrr PA, Cook NR, Chown MJ, Hebert LE, Hennekens CH, Taylor JO: Prevalence of Alzheimer’s disease in a community population of older persons: Higher than previously reported. JAMA 1989:262:2551-2556.
19. Mori IT, Kondo J, Ihara Y: Ubiquitin is a component of paired helical filaments in Alzheimer’s disease. Science 1987:235:1641-1644.
20. Perry G, Friedmann R, Shaw G, Chau V: Ubiquitin is delected in neurofibrillary' tangles and senile plaque neuritcs of Alzheimer disease brains. Proc Nall Acad Sci USA 1987:849: 3033-3036.
21. Wisniewski HM, Wegiel J: Do neurofibrillary tangles initiate plaque formation or is it ß-amy-loidosis that leads to NFT pathology? Neurobiol Aging 1995;16:341-343.
22. Braak H, Braak E: Neuropathological slageing of Alzheimer-related changes. Acta Neuropathol 1991:82:239-259.
23. Silverman W, Popovitch E, Schupf N, Zigman WB, Rabc A, Scrsen E, Wisniewski HM: Alzheimer neuropathology in mentally retarded adults: Statistical independence of regional amyloid plaque and neurofibrillary tangle densities. Acta Neuropathol 1993:85:260-266.
24. Armstrong RA, Myers D, Smith CUM: The spatial patterns of plaques and tangles in Alzheimer's disease do not support the’cascade hypothesis'. Dementia 1993:4:16-20.
25. Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskeil PCI, Rimmler JB, Locke PA, Comically PM, Schmader KE, Small GW, Roses AD, Haines JL, Pericak-Vancc MA: Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Gen 1994:7:180-184.
26. Wisniewski T, Castano EM, Golabek A, Vogel T, Frangione B: Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. Am J Pathol 1994:145:1030-1035.
27. Strittmatter WJ, Weisgraber KH, Goedert M, Saunders AM, Huang D, Corder EH, Dong L-M, Jakes R, Alberts MJ, Gilbert JR, Han S-H, Hulette C, Einstein G, Schmechel DE, Pericak-Vancc M, Roses AD: Hypothesis: Microtubule instability and paired helical filament formation in the Alzheimer disease brain arc related to apolipoprotein F. genotype. Exp Neurol 1994:125:163-171.
28. Wisniewski T, Morelli L, Wegiel J, Levy E, Wisniewski HM, Frangione B: The influence of apolipoprotein E isotypes on Alzheimer’s disease pathology in 40 cases of Down’s syndrome. Ann Neurol 1995:37:136-138.
29. Hardy J, Crook R, Perry R, Raghavan R, Roberts G: Apo E genotype and Down’s syndrome. Lancet 1994:34;979-980.
30. Brown WT, Wisniewski HM: Genetics of human aging. Rev Biol Res Aging 1983:1:81-99.
31. Sparks DL, Hunsaker I: Down’s syndrome: Occurrence of ALZ-50 reactive neurons and the formation of senile plaques. J Neurol Sci 1992: 109:77-82.
32. Sylvester PE: The hippocampus in Down's Syndrome. J Mem Defie Res 1983:27:227-236.