Human immune response to HIV-1 Nef. II. Induction of HIV-1/HIV-2 Nef cross-reactive cytotoxic T lymphocytes in peripheral blood lymphocytes of non-infected healthy individuals

International Immunology

Volumn 8, Issue 4, 1996, Pages 577-584

  Lucchiarr Hartz, Maria ^a,c   Bauer, Monika ^b   Niedermann, Gabriele ^a   Maier, Bernhard ^a   Meyerhans, Andreas ^b   Eichmann, Klaus ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c INSTITUTO BUTANTAN   (Brazil)

Author keywords

Cytotoxic T lymphocytes; HIV Nef; HIV 1; HIV 2; Human

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HLA A2 ANTIGEN; HLA B7 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ARTICLE; B LYMPHOBLAST; CONTROLLED STUDY; CROSS REACTION; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IMMUNOGENICITY; NONHUMAN; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SEROLOGY; VIRUS CELL TRANSFORMATION; VIRUS GENE;

ANTIGENS, CD8; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TRANSFORMED; CROSS REACTIONS; CYTOTOXICITY, IMMUNOLOGIC; GENE PRODUCTS, NEF; HIV-1; HIV-2; HLA-A2 ANTIGEN; HLA-B7 ANTIGEN; HUMANS; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

EID: 0029866832     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.4.577     Document Type: Article

References (44)

1. + T lymphocytes can control HIV infection in vitro by suppressing virus replication Science 234.1563
2. Tsubota, H , Lord, C I , Watkins, D. I , Morimoto, C and Letvin, N L 1989 A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes J Exp. Med 169:1421
3. + cell anti-HIV activity correlates with the clinical state of the infected individual. J Clin. Invest. 87:1462
4. + T cells, but not by rIFN beta, rIFN gamma, or recombinant tumor necrosis factor-alpha. J. Acquir Immune Defic Syndr. 4 480.
5. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection J. Virol. 68:6103
6. Koup, R A., Safrit, J T , Cao, Y , Andrews, C. A., McLeod, G., Borkowsky, W., Farthing, C and Ho, D D 1994 Temporal associations of cellular immune responses with the initial control of viremia in primary Human Immunodeficiency Virus type 1 syndrome J. Virol 68:4650.
7. Safrit, J , Andrews, C., Zhu, T , Ho, D. and Koup, R 1994 Characterization of human immunodefiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope J Exp Med 179:463
8. Klein, M., Baalen, C., Holwerda, A., Garde, S , Bende, R , Keet, I, Eeftinck-Schattenkerk, J.-K., Osterhaus, A., Schuitemaker, H and Miedema, F 1995. Kinetics of Gag-specific cytotoxic T lymphocytes responses during the clinical course of HIV-1 infection a longitudinal analysis of rapid progressors and long-term asymptomatics. J Exp Med. 181:1365.
9. Hoffenbach, A , Langlade-Demoyen, P., Dadaglio, G., Vilmer, E., Michel, F , Mayaud, C , Autran, B. and Plata, F. 1989. Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans. J Immunol 142:452.
10. Carmichael, A., Jin, X., Sissons, P. and Borysiewicz, L 1993. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection differential CTL responses to HIV-1 and Epstein-Barr virus in late disease J. Exp Med 177:249
11. Rinaldo, C., Huang, X., Fan, Z., Ding, M., Beltz, L., Logar, A., Panicali, D Mazzara, G , Liebmann, J , Cottrill, M and Gupta, P 1995 High level of anti-human immunodeficiency virus type 1 (HIV) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors J Virol. 69:5838
12. Pantaleo, G., Menzo, S , Vaccarezza, M., Graziosi, C., Cohen, O J Demarest, J F, Orenstein, J M , Fox, C., Schrager, L. K , Margolick J B , Buchbinder, S , Giorgi, J V. and Fauci, A. S 1995 Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N. Engl J Med. 332.209
13. Cao, Y , Qin L., Zhang, L , Safrit, J. and Ho, D 1995 Virologic and immunologic characterization of long-term survivors of human immunodefiency virus type 1 infection N. Engl J Med 332.201.
14. Rowland-Jones, S., Sutton, S , Ariyoshi, K , Dong, T , Gotch, F , McAdam, S , Whitby D , Sabally, S , Gallimore, A , Corrah, T., Takiguchi, M , Schultz, T , McMichael, A. and Whittle, H. 1995 HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women Nature Med 1 59
15. Langlade-Demoyen, P , Ngo-Glang-Huong, N , Ferchal, F and Oksenhendler, E 1994 Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients. J Clin Invest. 93 1293
16. Klotman, M E , Kim, S , Buchbinder, A , DeRossi, A , Baltimore, D. and Wong-Staal, F 1991 Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes Proc Natl Acad Sci. USA 88 5011.
17. Purcell, D. F. and Martin, M. A 1993 Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity. J. Virol 67 6365.
18. Bahraoui, E., Yagello, M , Billaud, J N , Sabatier, J M., Guy, B , Muchmore, E G and Gluckman, J. C. 1990. Immunogenicity of the human immunodeficiency virus (HIV) recombinant nef gene product. Mapping of T-cell and B-cell epitopes in immunized chimpanzees AIDS Res. Hum. Retrovir. 6:1087.
19. Hadida, F , Parrot, A., Kieny, M. P , Sadat-Sowti, B , Mayaud, C. and Debre, P. A. 1992. Carboxyl-terminal and central regions of human immunodeficiency virus-1 NEF recognized by cytotoxic T lymphocytes from lymphoid organs. An in vitro limiting dilution analysis J Clin. Invest. 89:53
20. Estaquier, J , Boutillon, C., Ameisen, J C., Gras-Masse, H , Delanoye, A. L , Dixson, A , Tartar, A., Capron, A. and Auriault, C. 1992. Determination of B-cell epitopes of nef HIV-1 protein: immunogenicity related to their structure Mol Immunol 29.1337.
21. Culmann-Penciolelli, B., Lamhamedi-Cherradi, S , Couillin, I , Guegan, N., Levy, J-P, Guillet, J.-G and Gomard, E. 1994 Identification of multirestricted immunodominant regions recognized by cytolytic T lymphocytes in the human immunodeficiency virus type 1 Nef protein J Virol 68:7336.
22. Du, Z., Lang, S. M., Sasseville, V G., Lackner, A. A , Ilyinskii, P O , Daniel, M. D., Jung, J., U. and Desrosiers, R C. 1995 Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell 82:665.
23. Kestler, H. 3., Ringler, D J , Mori, K., Panicali, D. L., Sehgal, P K., Daniel, M D. and Desrosiers, R. C 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651
24. Jamieson, B D , Aldrovani, G. M and Planelles, V. 1994 Requirement of HIV nef for in vivo replication and pathogenicity J. Virol 68:3478
25. Kirchhoff, F., Greenough, T. C., Brettler, D. B , Sullivan, J. L. and Desrosiers, R. C 1995. Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. New Engl. J. Med. 332:228
26. Schwartz, O., Marechal, V., Danos, O. and Heard, J M. 1995. Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell J Virol 69 4053
27. Nixon, D. F , Broliden, K , Ogg, G. and Broliden, P A 1992. Cellular and humoral antigenic epitopes in HIV and SIV Immunology 76:515.
28. Riviere, Y , Robertson, M. N and Buseyne, F 1994 Cytotoxic T lymphocytes in human immunodeficiency virus infection: regulator genes. Curr. Top Microbiol Immunol 189.65
29. Hadida, F , Haas, G., Zimmermann, N., Hosmalin, A., Spohn, R., Samn, A., Jung G , Debre, P. and Autran, B. 1995 CTLs from lymphoid organs recognize an optimal HLA-A2-restricted and HLA-B52-restricted nonapeptide and several epitopes in the C-terminal region of HIV-1 Nef J Immunol. 154.4174.
30. Chenciner, N., Michel, F., Dadaglio, G , Langlade-Demoyen, P., Hoffenbach, A., Leroux, A , Garcia-Pons, F., Rautmann, G , Guy, B , Guillon, J -M , Mayaud, C , Girard, M , Autran, B , Kieny, M -P and Plata, F 1989 Multiple subsets of HIV-specific cytotoxic T lymphocytes in humans and in mice. Eur. J Immunol 19 1537
31. - T lymphocytes of non-infected donors contain cytotoxic T lymphocyte precursors at high frequency Int. Immunol. 6:1739
32. Merkenschlager, M., Terry, L , Edwards, R. and Beverley, P C 1988 Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1, implications for differential CD45 expression in T cell memory formation. Eur J Immunol 18.1653.
33. Bourgalt, I , Gomez, A., Gomard, E. and Levy, J.-P 1991 Limiting-dilution analysis of the HLA restriction of anti-Epstein-Barr virus-specific cytolytic T lymphocytes Clin Exp Immunol 84:501
34. Nietfeld, W., Bauer, M. Fevrier, M , Maier, R , Holzwarth, B , Frank, R , Maier, B , Riviere, Y and Meyerhans, A 1995. Sequence constraints and recognition by CTL of an HLA-B27-retricted HIV-1 gag epitope J Immunol. 154 2188
35. Lucchiari, M , Niedermann, G., Leipner, C., Maier, B and Eichmann, K. 1994. The mouse bone marrow cell line S17 supports growth at limiting cell numbers of EBV-transformed human lymphoblastoid B cell lines Immunol Lett 40:189
36. Guyader, M , Emerman, M , Sonigo, P., Clavel, F , Montagnier, L. and Alizon, M 1987 Genome organisation and transactivation of the human immunodeficiency virus type 2 Nature 326.662.
37. Lamhamedi-Cherradi, S , Culmann-Penciolelli, B , Guy, B , Kieny, M P , Dreyfus, F , Saimot, A G , Sereni, D , Sicard, D., Levy, J P. and Gomard, E. 1992 Qualitative and quantitative analysis of human cytotoxic T-lymphocyte responses to HIV-1 proteins AIDS 6:1249
38. Delassus, S., Cheynier, R. and Wain-Hobson, S 1991 Evolution of human immunodefiency virus type 1 nef and long terminal repeat sequences over 4 years in vivo and in vitro. J Virol. 65 225.
39. Harris, M , Hislop, S , Patsilinacos, P and Neil, J C 1992. In vivo derived HIV-1 nef gene products are heterogeneous and lack detectable nucleotide binding activity AIDS Res. Hum. Retrovir. 8:537
40. Couillin, I , Culmann-Penciolelli, B , Gomard, E., Choppin, J , Levy, J , Quillet, J. and Saragosti, S 1994. Impaired cytotoxic T lymphocyte recognition due to genetic variation in the main immunogenic region of the human immunodefiency virus 1 NEF protein J. Exp Med 180:1129.
41. Niedermann, G., Butz, S., Ihlenfeld, H. G., Grimm, R., Lucchiari, M , Hoschutzky, H., Jung, G , Maier, B and Eichmann, K. 1995 Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules Immunity 2:289
42. Myers G., Wain-Hobson, J , Korber, B , Smith, R F. and Pavlakos, G. N 1993 A compilation and analysis of nucleic acid and amino acid sequences In Myers, G , Wain-Hobson, J , Korber, B , Smith, R F and Pavlakos, G N , eds, Human Retroviruses and AIDS Los Alamos National Laboratory, Los Alamos, NM
43. Nixon, D F , Huet, S , Rothbard, J , Kieny, M. P , Delchambre, M , Thiriart, C R , Gotch, F. M and McMichael, A. J 1990. An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope AIDS 4.841
44. Udaka, K , Wiesmuller, K H, Kienle, S , Jung, G and Walden, P 1995 Decrypting the structure of major histocompatibility complex class I-restricted cytotoxic T lymphocyte epitopes with complex peptide libraries J Exp. Med 181 2097