Tumor suppressor genes: At the crossroads of molecular carcinogenesis, molecular epidemiology, and human risk assessment

Preventive Medicine

Volumn 25, Issue 1, 1996, Pages 10-12

  Harris, Curtis C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN B1; CARCINOGEN; DINUCLEOTIDE; PROTEIN P53; TRANSCRIPTION FACTOR; VIRUS PROTEIN;

CANCER EPIDEMIOLOGY; CANCER RISK; CARCINOGEN DNA INTERACTION; CARCINOGENESIS; CONFERENCE PAPER; GENE ACTIVITY; GENE MUTATION; HUMAN; LIVER CANCER; LIVER TUMOR; LUNG CANCER; PRIORITY JOURNAL; PROTO ONCOGENE; RISK ASSESSMENT; RISK FACTOR; SKIN CARCINOMA; TUMOR SUPPRESSOR GENE;

EID: 0029866458     PISSN: 00917435     EISSN: None     Source Type: Journal    
DOI: 10.1006/pmed.1996.0005     Document Type: Conference Paper

References (33)

1. Harris CC. Chemical and physical carcinogenesis: advances and perspectives. Cancer Res 1991; 51:5023s-44s.
2. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science 1991; 253:49-53.
3. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994; 55:4855-78.
4. Takeshima Y, Seyama T, Bennett WP, Akiyama M, Tokuoka S, Inai K, Mabuchi K, Land CE, Harris CC. p53 mutations in lung cancers from non-smoking atomic-bomb survivors. Lancet 1993; 342:1520-1.
5. Guinee DG, Travis WD, Trivers GE, DeBenedetti VM, Cawley HM, Welsh JA, Bennett WP, Jett J, Colby TV, Tazelaar H, Abbonanzo SL, Pairolero P, Trastek V, Caporaso NE, Liotta LA, Harris CC. Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and C-erbB-2 expression. Carcinogenesis 1995; 16:993-1002.
6. Evans MK, Taffe BG, Harris CC, Bohr VA. DNA strand bias in the repair of the p53 gene in normal human and xeroderma pigmentosum group C fibroblasts. Cancer Res 1993; 53:5377-81.
7. Vahakangas KH, Samet JM, Metcalf RA, Welsh JA, Bennett WP, Lane DP, Harris CC. Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners. Lancet 1992; 339:576-80.
8. Bennett WP, Hollstein MC, Metcalf RA, Welsh JA, He A, Zhu S, Kusters I, Resau JH, Trump BF, Lane DP, Harris CC. p53 mutation and protein accumulation during multistage human esophageal carcinogenesis. Cancer Res 1992; 52:6092-7.
9. Bartek J, Bartkova J, Vojtesek B, Staskova Z, Rejthar A, Kovarik J, Lane DP. Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro. Int J Cancer 1990; 46:839-44.
10. Davidoff AM, Humphrey PA, Iglehart JD, and Marks JR. Genetic basis for p53 overexpression in human breast cancer. Proc Natl Acad Sci USA 1991; 88:5006-10.
11. Sundaresan V, Ganly P, Hasleton P, Rudd R, Sinha G, Bleehen NM, Rabbits P. p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. Oncogene 1992; 7:1989-97.
12. Nuorva K, Soini Y, Kamel D, Autio-Harmainen H, Risteli L, Risteli J, Vahakangas K, Paakko P. Concurrent p53 expression in bronchial dysplasias and squamous cell lung carcinomas. Am J Pathol 1993; 142:725-32.
13. Sozzi G, Miozzo M, Donghi R, Pilotti S, Cariani CT, Pastorino U, Della Porta G, Pierotti MA. Deletions of 17p and p53 mutations in preneoplastic lesions of the lung. Cancer Res 1992; 52:6079-82.
14. Hsu IC, Metcalf RA, Sun T, Welsh J, Wang NJ, Harris CC. p53 gene mutational hotspot in human hepatocellular carcinomas from Qidong, China. Nature 1991; 350:427-8.
15. Bressac B, Kew M, Wands J, Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 1991; 350:429-31.
16. Scorsone KA, Zhou YZ, Butel JS, Slagle BL. p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China. Cancer Res 1992; 52:1635-8.
17. Li D, Cao Y, He L, Wang NJ, Gu J. Aberrations of p53 gene in human hepatocellular carcinoma from China. Carcinogenesis 1993; 14:169-73.
18. Aguilar F, Harris CC, Sun T, Hollstein M, Cerutti P. Geographic variation of p53 mutational profile in nonmalignant human liver. Science 1994; 264:1317-9.
19. Maguire HF, Hoeffler JP, Siddiqui A. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 1991; 252:842-4.
20. Shirakata Y, Kawada M, Fujiki Y, Sano H, Oda M, Yaginuma K, Kobayashi M, Koike K. The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells. Jpn J Cancer Res 1989; 80:617-21.
21. Kekul e″ AS, Lauer U, Meyer M, Caselmann WH, Hofschneider PH, Koshy R. The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature 1990; 343:457-61.
22. Twu JS, Schloemer RH. Transcriptional trans-activating function of hepatitis B virus. J Virol 1987; 61:3448-53.
23. Spandau DF, Lee CH. Trans-activation of viral enhancers by the hepatitis B virus X protein. J Virol 1988; 62:427-34.
24. Caselmann WH, Meyer M, Kekulë AS, Lauer U, Hofschneider PH, Koshy R. A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA. Proc Natl Acad Sci USA 1990; 87:2970-4.
25. Benn J, Schneider RJ. Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc Natl Acad Sci USA 1994; 91:10350-4.
26. Wang XW, Forrester K, Yeh H, Feitelson MA, Gu JR, Harris CC. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci USA 1994; 91: 2230-4.
27. Hino O, Nomura K, Ohtake K, Kawaguchi T, Sugano H, Kitagawa T. Instability of integrated hepatitis B virus DNA with inverted repeat structure in a transgenic mouse. Cancer Genet Cytogenet 1989; 37:273-8.
28. Hino O, Tabata S, Hotta Y. Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA. Proc Natl Acad Sci USA 1991; 88:9248-52.
29. Brash DE, RudolphJA, Simon JA, Lin A, McKenna GJ, BadenHP, Halperin AJ, Ponten J. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA 1991; 88:10124-8.
30. Taylor JA, Watson MA, Devereux TR, Michels RY, Saccomanno G, Anderson M. Mutational hotspot in the p53 gene in radon-associated lung tumors from uranium miners. Lancet 1994; 343:86-7.
31. Hollstein M, Marion MJ, Lehman T, Welsh J, Harris CC, Martel-Planche G, Kusters I, Montesano R. p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis 1994; 15:1-3.
32. Harris CC, Hollstein M. Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 1993; 329:1318-27.
33. Shields PG, Harris CC. Molecular epidemiology and the genetics of environmental cancer. JAMA 1991; 266:681-7.