Treatment of hepatic failure-1996: Current concepts and progress toward liver dialysis

American Journal of Kidney Diseases

Volumn 27, Issue 5, 1996, Pages 605-621

  Sussman, N L ^a   Lake, J R ^a  

^a NONE   (United States)

Author keywords

acute liver failure; artificial liver; fulminant hepatic failure; Liver failure; renal dialysis

Indexed keywords

ACUTE KIDNEY TUBULE NECROSIS; ARTIFICIAL LIVER; BLOOD CLOTTING DISORDER; HEMODIALYSIS; HEPATIC ENCEPHALOPATHY; HEPATORENAL SYNDROME; HUMAN; INTENSIVE CARE; INTRACRANIAL HYPERTENSION; LIVER FAILURE; LIVER FUNCTION; LIVER REGENERATION; LIVER TRANSPLANTATION; MULTIPLE ORGAN FAILURE; ORGAN DONOR; REVIEW;

EID: 0029866230     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0272-6386(96)90094-3     Document Type: Review

References (139)

1. C Trey CS Davidson The management of fulminant hepatic disease H Popper F Schaffner Progress in Liver Disease 1970 Grune & Stratton New York, NY 282 298
2. J Bernuau B Rueff JP Benhamou Fulminant and subfulminant liver failure: Definitions and causes Semin Liver Dis 6 1986 97 106
3. JR Lake NL Sussman Determining prognosis in patients with fulminant hepatic failure: When you absolutely, positively have to know the answer Hepatology 21 1995 879 882
4. JG O'Grady GJ Alexander KM Hayllar R Williams Early indicators of prognosis in fulminant hepatic failure Gastroenterology 97 1989 439 445
5. M Daas DJ Plevak EFM Wijdicks J Rakela RH Wiesner DG Piepgras WF Dunn JL Steers Acute liver failure: Results of a 5-year clinical protocol Liver Transplant Surg 1 1995 210 219
6. R Williams J Wendon Indications for orthotopic liver transplantation in fulminant liver failure Hepatology 20 1994 S5 S10
7. CW Lloyd CE Johnson Management of hypophosphatemia Ther Rev 7 1988 123 128
8. A Makin R Williams The current management of paracetamol overdosage Br J Clin Pract 48 1994 144 148
9. LF Prescott GR Sutherland J Park IJ Smith AT Proudfoot Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning Lancet 2 1976 109 113
10. BH Rumack RC Peterson GG Koch IA Amara Acetaminophen overdose 662 cases with evaluation of oral acetylcysteine treatment Arch Intern Med 141 1981 380 385
11. MJ Smilkstein GL Knapp KW Kulig BH Rumack Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose Analysis of the national multicenter study (1976 to 1985) N Engl J Med 319 1988 1557 1562
12. JS Crippin JB Gross Jr KD Lindor Increased intracranial pressure and hepatic encephalopathy in chronic liver disease Am J Gastroenterol 87 1992 879 882
13. DD Mousseau RF Butterworth Current theories on the pathogenesis of hepatic encephalopathy Proc Soc Exp Biol Med 206 1994 329 344
14. AT Blei Cerebral edema and intracranial hypertension in acute liver failure: Distinct aspects of the same problem Hepatology 13 1991 376 379 (editorial)
15. NL Sussman Fulminant hepatic failure D Zakim TD Boyer Hepatology: A Textbook of Liver Disease 1995 Saunders Philadelphia, PA (in press)
16. The brain in fulminant hepatic failure Anonymous Lancet 338 1991 156 157 (editorial)
17. R Williams AE Gimson Intensive liver care and management of acute hepatic failure Dig Dis Sci 36 1991 820 826
18. SJ Munoz M Robinson B Northrup R Bell M Moritz B Jarrell P Martin WC Maddrey Elevated intracranial pressure and computed tomography of the brain in fulminant hepatocellular failure Hepatology 13 1991 209 212
19. SD Lidofsky NM Bass MC Prager DE Washington AE Read TL Wright NL Ascher JP Roberts BF Scharschmidt JR Lake Intracranial pressure monitoring and liver transplantation for fulminant hepatic failure Hepatology 16 1992 1 7
20. AT Blei S Olafsson S Webster R Levy Complications of intracranial pressure monitoring in fulminant hepatic failure Lancet 341 1993 157 158
21. RT Keays GJ Alexander R Williams The safety and value of extradural intracranial pressure monitors in fulminant hepatic failure J Hepatol 18 1993 205 209
22. NL Ascher JR Lake JC Emond JP Roberts Liver transplantation for fulminant hepatic failure Arch Surg 128 1993 677 682
23. R Keays D Potter J O'Grady T Peachey G Alexander R Williams Intracranial and cerebral perfusion pressure changes before, during and immediately after orthotopic liver transplantation for fulminant hepatic failure Q J Med 79 1991 425 433
24. MC Prager DE Washington SD Lidofsky SD Kelley JD White Intracranial pressure monitoring during liver transplant without venovenous bypass for fulminant hepatic failure Transplant Proc 25 1993 1841
25. SJ Munoz MJ Moritz R Bell B Northrup P Martin J Radomski Factors associated with severe intracranial hypertension in candidates for emergency liver transplantation Transplantation 55 1993 1071 1074
26. A Davenport EJ Will AM Davison Effect of posture on intracranial pressure and cerebral perfusion pressure in patients with fulminant hepatic and renal failure after acetaminophen self-poisoning Crit Care Med 18 1990 286 289
27. SJ Munoz Difficult management problems in fulminant hepatic failure Semin Liver Dis 13 1993 395 413
28. RJ Ede AE Gimson D Bihari R Williams Controlled hyperventilation in the prevention of cerebral oedema in fulminant hepatic failure J Hepatol 2 1986 43 51
29. JA Wendon PM Harrison R Keays R Williams Cerebral blood flow and metabolism in fulminant liver failure Hepatology 19 1994 1407 1413
30. J Canalese AE Gimson C Davis PJ Mellon M Davis R Williams Controlled trial of dexamethasone and mannitol for the cerebral oedema of fulminant hepatic failure Gut 23 1982 625 629
31. A Forbes GJ Alexander JG O'Grady R Keays R Gullan S Dawling R Williams Thiopental infusion in the treatment of intracranial hypertension complicating fulminant hepatic failure Hepatology 10 1989 306 310
32. SJ Munoz MJ Moritz P Martin S Westerberg B Northrup R Bell S Yang J Radomski Relationship between cerebral perfusion pressure and systemic hemodynamics in fulminant hepatic failure Transplant Proc 25 1993 1776 1778
33. DJ Kramer S Aggarwal M Martin J Darby W Obrist A Rosenbloom G Murray P Linden A Miro Management options in fulminant hepatic failure Transplant Proc 23 1991 1895 1898
34. S Aggarwal D Kramer H Yonas W Obrist Y Kang M Martin R Policare Cerebral hemodynamic and metabolic changes in fulminant hepatic failure: A retrospective study Hepatology 19 1994 80 87
35. PM Harrison JA Wendon AE Gimson GJ Alexander R Williams Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure N Engl J Med 324 1991 1852 1857
36. D Bihari AE Gimson M Waterson R Williams Tissue hypoxia during fulminant hepatic failure Crit Care Med 13 1985 1034 1039
37. B Schneeweiss J Pammer K Ratheiser B Schneider C Madl L Kramer A Kranz P Ferenci W Druml G Grimm K Lenz A Gangl Energy metabolism in acute hepatic failure Gastroenterology 105 1993 1515 1521
38. JA Wendon PM Harrison R Keays AE Gimson GJ Alexander R Williams Effects of vasopressor agents and epoprostenol on systemic hemodynamics and oxygen transport in fulminant hepatic failure Hepatology 15 1992 1067 1071
39. JG O'Grady AE Gimson CJ O'Brien A Pucknell RD Hughes R Williams Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure Gastroenterology 94 1988 1186 1192
40. RJ McMurtry WR Snodgrass JR Mitchell Renal necrosis, glutathione depletion, and covalent binding after acetaminophen Toxicol Appl Pharmacol 46 1978 87 100
41. JG Kleinman RV Breitenfield DA Roth Acute renal failure associated with acetaminophen ingestion: Report of a case and review of the literature Clin Nephrol 14 1980 201 205
42. WH Jeffery WE Lafferty Acute renal failure after acetaminophen overdose: Report of two cases Am J Hosp Pharm 38 1981 1355 1358
43. I Cobden CO Record MK Ward DN Kerr Paracetamol-induced acute renal failure in the absence of fulminant liver damage BMJ 284 1982 21 22
44. RW Curry Jr JD Robinson MJ Sughrue Acute renal failure after acetaminophen ingestion JAMA 247 1982 1012 1014
45. LF Prescott AT Proudfoot RJ Cregeen Paracetamolinduced acute renal failure in the absence of fulminant liver damage BMJ 284 1982 421 422 (letter)
46. P Pillans C Hall Paracetamol-induced acute renal failure in the absence of severe liver damage S Afr Med J 67 1985 791 792
47. S Dabbagh RW Chesney Acute renal failure related to acetaminophen (paracetamol) overdose without fulminant hepatic disease Int J Pediatr Nephrol 6 1985 221 224
48. A Davenport R Finn Paracetamol (acetaminophen) poisoning resulting in acute renal failure without hepatic coma Nephron 50 1988 55 56
49. S Bjorck CT Svalander M Aurell Acute renal failure after analgesic drugs including paracetamol (acetaminophen) Nephron 49 1988 45 53
50. S Papper JL Belsky KH Bleifer Renal failure in Laennec's cirrhosis of the liver Description of clinical and laboratory features Ann Intern Med 51 1959 759 773
51. L Shear J Kleinerman GJ Gabuzda Renal failure in patients with cirrhosis Clinical and pathological characteristics Am J Med 39 1965 184 198
52. SP Wilkinson B Portmann D Hurst R Williams Pathogenesis of renal failure in cirrhosis and fulminant hepatic failure Postgrad Med J 51 1975 503 505
53. F Guarner RD Hughes AE Gimson R Williams Renal function in fulminant hepatic failure: Haemodynamics and renal prostaglandins Gut 28 1987 1643 1647
54. S Iwatsuki MM Popovtzer JL Corman M Ishikawa CW Putnam FH Katz TE Starzl Recovery from “hepatorenal syndrome” after orthotopic liver transplantation N Engl J Med 289 1973 1155 1159
55. MH Koppel JW Coburn MM Mims H Goldstein JD Boyle ME Rubini Transplantation of cadaveric kidneys from patients with hepatorenal syndrome Evidence for the functional nature of renal failure in advanced liver disease N Engl J Med 280 1969 1367 1371
56. AK Mandal M Lansing A Fahmy Acute tubular necrosis in hepatorenal syndrome: An electron microscopy study Am J Kidney Dis 2 1982 363 374
57. IF Platt JM Rubin JH Ellis Acute renal failure: Possible role of duplex Doppler US in distinction between acute prerenal failure and acute tubular necrosis Radiology 179 1991 419 423
58. J Stadler D Barton H Beil-Moeller S Diekman C Hierholzer W Erhard C-D Heidecke Hepatocyte nitric oxide biosynthesis inhibits glucose output and competes with urea synthesis for L-arginine Am J Physiol 268 1995 G183 G188
59. H Ring-Larsen U Palazzo Renal failure in fulminant hepatic failure and terminal cirrhosis: A comparison between incidence, types, and prognosis Gut 22 1981 585 591
60. MJ Dunn MS Simonson P Mene The role of eicosanoids in the control of mesangial function Trans Am Clin Climatol Assoc 98 1986 71 79
61. KF Badr DK Deboer K Takahashi RC Harris A Fogo HR Jacobson Glomerular responses to platelet-activating factor in the rat: Role of thromboxane A2 Am J Physiol 256 1989 F35 F43
62. P Mene MS Simonson MJ Dunn Prostaglandins, thromboxane and leukotrienes in the control of mesangial function Adv Exp Med Biol 259 1989 167 197
63. RD Zipser GH Radvan IJ Kronborg R Duke TE Little Urinary thromboxane B2 and prostaglandin E2 in the hepatorenal syndrome: Evidence for increased vasoconstrictor and decreased vasodilator factors Gastroenterology 84 1983 697 703
64. K Moore J Wendon M Frazer J Karani R Williams K Badr Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome N Engl J Med 327 1992 1774 1778
65. MZ Panos JV Anderson A Forbes N Payne JD Slater L Rees R Williams Human atrial natriuretic factor and renin-aldosterone in paracetamol induced fulminant hepatic failure Gut 32 1991 85 89
66. JP Tolins RM Palmer S Moncada L Raij Role of endothelium-derived relaxing factor in regulation of renal hemodynamic responses Am J Physiol 258 1990 H655 H662
67. A Davenport AM Davison EJ Will Are changes in intracranial pressure during intermittent machine haemofiltration dependent upon membrane biocompatibility? Int J Artif Organs 12 1989 703 707
68. A Davenport EJ Will AM Davison S Swindells AT Cohen KJ Miloszewski MS Losowsky Changes in intracranial pressure during machine and continuous haemofiltration Int J Artif Organs 12 1989 439 444
69. A Davenport EJ Will AM Davison Early changes in intracranial pressure during haemofiltration treatment in patients with grade 4 hepatic encephalopathy and acute oliguric renal failure Nephrol Dial Transplant 5 1990 192 198
70. PG Langley RD Hughes A Forbes R Keays R Williams Controlled trial of antithrombin III supplementation in fulminant hepatic failure J Hepatol 17 1993 326 331
71. N Rolando F Harvey J Brahm J Philpott-Howard G Alexander M Casewell E Fagan R Williams Fungal infection: A common, unrecognised complication of acute liver failure J Hepatol 12 1991 1 9
72. JM Salmeron L Tito A Rimola A Mas MA Navasa J Llach A Gines P Gines V Arroyo J Rodes Selective intestinal decontamination in the prevention of bacterial infection in patients with acute liver failure J Hepatol 14 1992 280 285
73. N Rolando F Harvey J Brahm J Philpott-Howard G Alexander A Gimson M Casewell E Fagan R Williams Prospective study of bacterial infection in acute liver failure: An analysis of fifty patients Hepatology 11 1990 49 53
74. J Rakela SM Lange J Ludwig WP Baldus Fulminant hepatitis: Mayo Clinic experience with 34 cases Mayo Clin Proc 60 1985 289 292
75. H Bismuth D Samuel J Gugenheim D Castaing J Bernuau B Rueff JP Benhamou Emergency liver transplantation for fulminant hepatitis Ann Intern Med 107 1987 337 341
76. TJ Walsh SR Hamilton Disseminated aspergillosis complicating hepatic failure Arch Intern Med 143 1983 1189 1191
77. N Rolando A Gimson J Wade J Philpott-Howard M Casewell R Williams Prospective controlled trial of selective parenteral and enteral antimicrobial regimen in fulminant liver failure Hepatology 17 1993 196 201
78. N Rolando JJ Wade A Stangou J Wendon A Gimson J Philpott-Howard R Williams Prospective study comparing prophylactic parenteral antimicrobials, with or without enteral decontamination, in patients with acute liver failure Hepatology 20 1994 125A (abstr)
79. BR MacDougall RJ Bailey R Williams H2-receptor antagonists and antacids in the prevention of acute gastrointestinal haemorrhage in fulminant hepatic failure Two controlled trials Lancet 1 1977 617 619
80. BR MacDougall R Williams H2-receptor antagonist in the prevention of acute upper gastrointestinal hemorrhage in fulminant hepatic failure: A controlled trial Gastroenterology 74 1978 464 465
81. SJ O'Keefe RR Abraham M Davis R Williams Protein turnover in acute and chronic liver disease Acta Chir Scand Suppl 507 1981 91 101
82. JM Sanchez-Tapias A Mas J Costa M Bruguera A Mayor AM Ballesta C Compernolle J Rodes Recombinant alpha 2c-interferon therapy in fulminant viral hepatitis J Hepatol 5 1987 205 210
83. M Abecassis JA Falk L Makowka VJ Dindzans RE Falk GA Levy 16,16 Dimethyl prostaglandin E2 prevents the development of fulminant hepatitis and blocks the induction of monocyte/macrophage procoagulant activity after murine hepatitis virus strain 3 infection J Clin Invest 80 1987 881 889
84. SB Sinclair GA Levy Treatment of fulminant viral hepatic failure with prostaglandin E A preliminary report Dig Dis Sci 36 1991 791 800
85. P Sheiner S Sinclair P Greig A Logan LM Blendis G Levy A randomized control trial of prostaglandin E2 in the treatment of fulminant hepatic failure Hepatology 16 1992 88A (abstr)
86. RW Chapman D Forman R Peto R Smallwood Liver transplantation for acute hepatic failure? Lancet 335 1990 32 35
87. JC Emond PP Aran PF Whitington CE Broelsch AL Baker Liver transplantation in the management of fulminant hepatic failure Gastroenterology 96 1989 1583 1588
88. JG O'Grady J Wendon KC Tan D Potter S Cottam AT Cohen AE Gimson R Williams Liver transplantation after paracetamol overdose BMJ 303 1991 221 223
89. DJ Mutimer RCS Ayres JM Neuberger MH Davies J Holguin JAC Buckels AD Mayer P McMaster E Elias Serious paracetamol poisoning and the results of liver transplantation Gut 35 1994 809 814
90. SF Dodson K Dehara S Iwatsuki Liver transplantation for fulminant hepatic failure ASAIO J 40 1994 86 88
91. B Ringe R Pichlmayr N Lubbe A Bornscheuer E Kuse Total hepatectomy as temporary approach to acute hepatic or primary graft failure Transplant Proc 20 1988 552 557 suppl 1
92. WM Lee Total hepatectomy for acute liver failure: Don't take out my liver Gastroenterology 107 1994 894 897
93. B Ringe N Lubbe E Kuse U Frei R Pichlmayr Total hepatectomy and liver transplantation as two-stage procedure Ann Surg 218 1993 3 9
94. J Rozga L Podesta E LePage A Hoffman E Morsiani L Sher GM Woolf L Makowka AA Demetriou Control of cerebral oedema by total hepatectomy and extracorporeal liver support in fulminant hepatic failure Lancet 342 1993 898 899
95. E Ejlersen FS Larsen F Pott HJ Gyrtrup P Kirkegaard NH Secher Hepatectomy corrects cerebral hyperperfusion in fulminant hepatic failure Transplant Proc 26 1994 1794 1795
96. AA Shaked RW Busuttil Auxiliary liver transplantation: A negative viewpoint Hepatology 12 1990 173 175
97. K Boudjema D Cherqui D Jaeck M-P Chenard-Neu A Steib G Freis F Becmeur B Brunot U Simeoni J-P Bellocq J-D Tempe P Wolf J Cinqualbre Auxiliary liver transplantation for fulminant and subfulminant hepatic failure Transplantation 59 1995 218 223
98. HJ Metselaar EJ Hesselink S de Rave FJ ten Kate JS Lameris TH Groenland CB Reuvers W Weimar OT Terpstra SW Schalm Recovery of failing liver after auxiliary heterotopic transplantation Lancet 335 1990 1156 1157 (letter)
99. MJ Moritz BE Jarrell V Armenti J Radomski RA Carabasi G Zeitoun K Columbus R Rubin S Munoz W Maddrey Heterotopic liver transplantation for fulminant hepatic failure-A bridge to recovery Transplantation 50 1990 524 526
100. DA Stampfl SJ Munoz MJ Moritz R Rubin VT Armenti BE Jarrell WC Maddrey Heterotopic liver transplantation for fulminant Wilson's disease Gastroenterology 99 1990 1834 1836
101. P Opolon High-permeability membrane hemodialysis and hemofiltration in acute hepatic coma: Experimental and clinical results Artif Org 3 1979 354 360
102. P Opolon MC Lavallard C Huguet M Bidallier A Granger D Gallot P Bloch Hemodialysis versus cross hemodialysis in experimental hepatic coma Surg Gynecol Obstet 142 1976 845 853
103. AG Redeker HS Yamahiro Controlled trial of exchange-transfusion therapy in fulminant hepatitis Lancet 1 1973 3 6
104. J Kondrup T Almdal H Vilstrup N Tygstrup High volume plasma exchange in fulminant hepatic failure Int J Artif Organs 15 1992 669 676
105. NL Sussman JH Kelly Temporary hepatic support systems WC Maddrey MF Sorrell Transplantation of the Liver 1995 Appleton & Lange New York, NY 557 569
106. JJ Brems JR Hiatt KP Ramming WJ Quinones-Baldrich RW Busuttil Fulminant hepatic failure: The role of liver transplantation as primary therapy Am J Surg 154 1987 137 141
107. C Vickers J Neuberger J Buckels P McMaster E Elias Transplantation of the liver in adults and children with fulminant hepatic failure J Hepatol 7 1988 143 150
108. S Iwatsuki AC Stieber JW Marsh AG Tzakis S Todo B Koneru L Makowka RD Gordon TE Starzl Liver transplantation for fulminant hepatic failure Transplant Proc 21 1989 2431 4243
109. S Gallinger PD Greig G Levy LM Blendis EA Roberts RA Superina BR Taylor SM Strasberg MJ Phillips B Langer Liver transplantation for acute and subacute fulminant hepatic failure Transplant Proc 21 1989 2435 2438
110. D Devictor L Desplanques D Debray Y Ozier AM Dubousset J Valayer D Houssin O Bernard G Huault Emergency liver transplantation for fulminant liver failure in infants and children Hepatology 16 1992 1156 1162
111. AL Friedman E Maller D Piccoli L Plona MA Hoffman HT Lau Encouraging experience with aggressive liver transplantation for children with fulminant hepatic failure at a single transplant center Transplant Proc 26 1994 65 66
112. ES Siegelman DG Mitchell R Rubin MJ Moritz SJ Munoz JP Palazzo MD Rifkin Recovery of native liver after heterotopic liver transplantation for fulminant hepatic failure: MR studies J Comput Assist Tomogr 16 1992 152 154
113. EP Sandgren RD Palmiter JL Heckel CC Daugherty RL Brinster JL Degen Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene Cell 66 1991 245 256
114. JA Rhim EP Sandgren JL Degen RD Palmiter RL Brinster Replacement of diseased mouse liver by hepatic cell transplantation Science 263 1994 1149 1152
115. RS Chari BH Collins JC Magee JM Dimaio AD Kirk RC Harland RL McCann JL Platt WC Meyers Brief report: Treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation N Engl J Med 331 1994 234 237
116. U Fox AN Langnas LW Fristoe MS Shaefer JE Vogel DL Antonson JP Donovan TG Heffron RS Markin MF Sorrell BW Shaw Successful application of extracorporeal liver perfusion: A technology whose time has come Am J Gastroenterol 88 1993 1876 1881
117. D Castaing D Houssin H Bismuth Hepatic and Portal Surgery in the Rat 1980 Masson Paris, France
118. NL Sussman GT Gislason JH Kelly Extracorporeal liver support Application to fulminant hepatic failure J Clin Gastroenterol 18 1994 320 324
119. RA Shatford SL Nyberg SJ Meier JG White WD Payne WS Hu FB Cerra Hepatocyte function in a hollow fiber bioreactor: A potential bioartificial liver J Surg Res 53 1992 549 557
120. J Rozga F Williams MS Ro DF Neuzil TD Giorgio G Backfisch AD Moscioni R Hakim AA Demetriou Development of a bioartificial liver: Properties and function of a hollow-fiber module inoculated with liver cells Hepatology 17 1993 258 265
121. AP Li G Barker D Beck S Colburn R Monsell C Pellegrin Culturing of primary hepatocytes as entrapped aggregates in a packed bed bioreactor: A potential bioartificial liver In Vitro Cell Dev Biol 29A 1993 249 254
122. HO Jauregui CJ-P Mullon D Trenkler S Naik H Santangini P Press TE Muller BA Solomon In vivo evaluation of a hollow fiber liver assist device Hepatology 21 1995 460 469
123. NL Sussman MG Chong T Koussayer DE He TA Shang HH Whisennand JH Kelly Reversal of fulminant hepatic failure using an extracorporeal liver assist device Hepatology 16 1992 60 65
124. GT Gislason DD Lobdell JH Kelly NL Sussman A treatment system for implementing an extracorporeal liver assist device Artif Organs 18 1994 385 389
125. JH Kelly T Koussayer DE He MG Chong TA Shang HH Whisennand NL Sussman An improved model of acetaminophen-induced fulminant hepatic failure in dogs Hepatology 15 1992 329 335
126. NL Sussman JH Kelly Extracorporeal liver assist in the treatment of fulminant hepatic failure Blood Purif 11 1993 170 174
127. DF Neuzil J Rozga AD Moscioni MS Ro R Hakim WS Arnaout AA Demetriou Use of a novel bioartificial liver in a patient with acute liver insufficiency Surgery 113 1993 340 343
128. J Rozga L Podesta E Lepage E Morsiani AD Moscioni A Hoffman L Sher F Villamil G Woolf M McGrath L Kong H Rosen T Lanman J Vierling L Makowka AA Demetriou A bioartificial liver to treat severe acute liver failure Ann Surg 219 1994 538 546
129. EB Lepage J Rozga P Rosenthal F Watanabe HC Scott AM Talke AA Demetriou A bioartificial liver used as a bridge to liver transplantation in a 10-year-old boy Am J Crit Care 3 1994 224 227
130. NL Sussman JH Kelly Improved liver function following treatment with an extracorporeal liver assist device Artif Organs 17 1993 27 30
131. NL Sussman GT Gislason CA Conlin JH Kelly The Hepatix extracorporeal liver assist device: Initial clinical experience Artif Organs 18 1994 390 396
132. NL Sussman MJ Finegold JP Barish JH Kelly A case of syncytial giant-cell hepatitis treated with an extracorporeal liver assist device Am J Gastroenterol 89 1994 1077 1082
133. AJ Ellis J Wendon R Hughes P Langley NL Sussman JH Kelly GT Gislason R Williams A controlled trial of the Hepatix extracorporeal liver assist device (ELAD) in acute liver failure Hepatology 20 1994 140A (abstr)
134. F Hawker Fulminant hepatic failure GR Park The Liver 1993 Saunders London, United Kingdom 71 135
135. C Madl G Grimm P Ferenci L Kramer W Yeganehfar W Oder R Steininger C Zauner K Ratheiser F Stockenhuber K Lenz Serial recording of sensory evoked potentials: A noninvasive prognostic indicator in fulminant liver failure Hepatology 20 1994 1487 1494
136. SJ Munoz Prothrombin time in fulminant hepatic failure Gastroenterology 100 1991 1480 1481 (letter)
137. WM Lee Acute liver failure N Engl J Med 329 1993 1862 1872 erratum appears in
138. WM Lee Acute liver failure N Engl J Med 330 1994 584
139. NL Sussman JH Kelly The artificial liver Sci Am Sci Med 2 1995 68 77