Decreased 3α-hydroxysteroid dehydrogenase activity in peripheral blood lymphocytes from patients with primary open angle glaucoma

Experimental Eye Research

Volumn 62, Issue 1, 1996, Pages 39-46

  Weinstein, Bernard I ^a   Iyer, Radha B ^a   Binstock, Judith M ^a,b   Hamby, Carl V ^a   Schwartz, Ira S ^a   Moy, Fred H ^a   Wandel, Thaddeus ^a   Southren, A Louis ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b NEW YORK COLLEGE OF PODIATRIC MEDICINE   (United States)

Author keywords

3 hydroxysteroid dehydrogenase; cortisol metabolism; dihydrocortisol; glaucoma marker; lymphocytes; tetrahydrocortisol

Indexed keywords

3ALPHA HYDROXYSTEROID DEHYDROGENASE; MARKER;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; LYMPHOCYTE; OPEN ANGLE GLAUCOMA; PRIORITY JOURNAL;

EID: 0029865671     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.1996.0005     Document Type: Article

References (37)

1. Binstock, J. M., Iyer, R. B., Hamby, C. V., Fried, V. A., Schwartz, I. S., Weinstein, B. I. and Southren, A. L. (1992). Human hepatic 3 alpha-hydroxysteroid dehydrogenase: possible identity with human hepatic chlordecone reductase. Biochem. Biophys Res. Commun. 187, 760-6.
2. Boyum, A. (1977). Separation of lymphocytes, lymphocyte subgroups and monocytes: a review. Lymphology. 10, 71-6.
3. Clark, A. F., Wilson, K., Miggans, T. and Lane, D. (1993). Tetrahydrocortisol inhibits dexamethasone induced cytoskeletal reorganization in cultured human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 34 (Suppl), 2151 (Abstract).
4. Clark, A. F., McNatt, L. and Knepper, P. A. (1994). Angiostatic steroids as a new class of IOP lowering compounds. Invest. Ophthalmol Vis. Sci. 35 (Suppl), 1057 (Abstract).
5. Cope, C. L., (1972). Metabolic breakdown. In Adrenal Steroids and Disease, pp. 80-104. Lippincott: Philadelphia, U.S.A.
6. Fisher, L. and Van Belle, G. (1993). Biostatistics. John Wiley: New York, U.S.A.
7. Gustafsson, J. A., Mode, A., Norstedt, G. and Skett, P. (1983). Sex steroid induced changes in hepatic enzymes. Annu Rev Physiol. 45, 51-60.
8. Hara, A., Inoue, Y., Nakagawa, M., Naganeo, F. and Sawada, H. (1988). Purification and characterization of NADP +-dependent 3 alpha-hydroxysteroid dehydrogenase from mouse liver cytosol. J. Biochem. 103, 1027-34.
9. Huang, H., Li, P., Hamby, C. V., Reiss, K., Meggs, L. G. and Anversa, P. (1994). Alterations in angiotensin II receptor mediated signal transduction shortly after coronary artery constriction in the rat. Cardiovasc. Res. 28, 1564-73.
10. Ikeda, M., Hattori, H., Ikeda, N., Hayakawa, S. and Ohmori, S. (1984). Purification and characterization of the multiple forms of 3 alpha-hydroxysteroid dehydrogenase in rat liver cytosol. Hoppe. Seylers. Z. Physiol. Chem 365, 377-91.
11. Iyer, R. B., Binstock, J. M., Schwartz, I. S., Gordon, G. G., Weinstein, B. I. and Southren, A. L. (1990). Human hepatic cortisol reductase activities: enzymatic properties and substrate specificities of cytosolic cortisol delta 4-5 beta-reductase and dihydrocortisol-3 alpha-oxido-reductase(s). Steroids 55, 495-500.
12. Iyer, R. B., Binstock, J. M., Schwartz, I. S., Gordon, G. G., Weinstein, B. I. and Southren, A. L. (1992). Purification and properties of human hepatic 3 alpha- hydroxy-steroiddehydrogenase. J. Steroid. Biochem. Mol. Biol. 43, 343-9.
13. Iyer, R. B., Ye, H., Binstock, J. M., Hamby, C., Schwartz, I. S., Gordon, G., Weinstein, B. I., Hernandez, M. R. and Southren, A. L. (1993). Localization of 3 Alpha HSD in the human eye. Invest. Ophthalmol. Vis. Sci. 34 (Suppl), 1386 (Abstract).
14. Kawase, K., Steely, Jr. H. T. and Clark, A. F. (1994). The effect of dexamethasone and tetrahydrocortisol on protein expression in cultured human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 35 (Suppl), 2734 (Abstract).
15. Kudo, K., Amuro, Y., Hada, T. and Higashino, K. (1990). Purification and properties of 3 alpha-hydroxysteroid dehydrogenase as a 3-keto bile acid reductase from human liver cytosol. Biochim. Biophys Acta 1046, 12-18.
16. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-5.
17. McCartney, M. D., Wilson, K., Miggans, S. T. and Clark, A. F. (1994). Effect of dexamethasone and tetrahydrocortisol on cultured human trabecular meshwork cell microfilament and microtubular structure. Invest. Ophthalmol. Vis. Sci. 35 (Suppl), 2735. (Abstract).
18. Morikawa, T. and Amaoki, B. (1990). Purification and characterization of 3 alpha-hydroxysteroid dehydrogenase from chicken hepatic cytosol. J. Steroid Biochem. 37, 569-74.
19. Penning, T. M., Mukharji, I., Barrows, S. and Talalay, P. (1984). Purification and properties of a 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs. Biochem. J. 222, 601-11.
20. Penning, T. M. and Sharp, R. B. (1987). Prostaglandin dehydrogenase activity of purified rat liver 3 alphahydroxysteroid dehydrogenase. Biochem. Biophys Res. Commun. 148, 646-52.
21. Rozsival, P., Hampl, R., Obenberger, J., Starka, L. and Rehak, S. (1981). Aqueous humour and plasma cortisol levels in glaucoma and cataract patients. Curr. Eye Res. 1, 391-6.
22. Smithgall, T. E., Harvey, R. G. and Penning, T. M. (1986). Regio- and stereospecificity of homogeneous 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase for transdihydrodiol metabolites of polycyclic aromatic hydrocarbons. J. Biol. Chem 261, 6184-91.
23. Southren, A. L., Gordon, G. G., Munnangi, P. R., Vittek, J., Schwartz, J., Monder, C., Dunn, M. W. and Weinstein, B. I. (1983). Altered cortisol metabolism in cells cultured from trabecular meshwork specimens obtained from patients with primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 24, 1413-17.
24. Southren, A. L., Gordon, G. G., l'Hommedieu, D., Ravikumar, S., Dunn, M. W. and Weinstein, B. I. (1985). 5 beta-Dihydrocortisol: possible mediator of the ocular hypertension in glaucoma. Invest. Ophthalmol. Vis. Sci. 26, 393-5.
25. Southren, A. L., Hernandez, M. R., l'Hommedieu, D., Gordon, G. G. and Weinstein, B. I. (1986). Potentiation of collagen synthesis in explants of the rabbit eye by 5 beta-dihydrocortisol. Invest. Ophthalmol. Vis. Sci. 27, 1757-60.
26. Southren, A. L., l'Hommedieu, D., Gordon, G. G. and Weinstein, B. I. (1987). Intraocular hypotensive effect of a topically applied cortisol metabolite: 3 alpha, 5 beta-tetrahydrocortisol. Invest. Ophthalmol. Vis. Sci. 28, 901-3.
27. Southren, A. L., Wandel, T., Gordon, G. G. and Weinstein, B. I. (1994). Treatment of glaucoma with 3 alpha, 5 beta-tetrahydrocortisol: a new therapeutic modality. J. Ocul. Pharmacol. 10, 385-91.
28. Starka, L., Hampl, R., Bicikova, M. and Obenberger, J. (1976). Identification and radioimmunologic estimation of sexual steroid hormones in aqueous humor and vitreous of rabbit eye. Albrecht. Von. Graefes, Arch Klin. Exp. Ophthalmol. 199, 261-6.
29. Starka, L., Hampl, R., Bicikova, M. and Obenberger, J. (1977a). [Steroid hormones in plasma and aqueous of bovine eye]. Cesk. Oftalmol. 33, 103-5.
30. Starka, L., Hampl, R., Gregorova, I. and Obenberger, J. (1977b). Aldosterone: its occurrence, metabolism and binding in the rabbit eye. Exp. Eye Res. 25, 91-8.
31. Takikawa, H., Stolz, A., Kuroki, S. and Kaplowitz, N. (1990). Oxidation and reduction of bile acid precursors by rat hepatic 3 alpha-hydroxysteroid dehydrogenase and inhibition by bile acids and indomethacin. Biochim. Biophys. Acta. 1043, 153-6.
32. Takikawa, H., Fujiyoshi, M., Nishikawa, K. and Yamanaka, M. (1992). Purification of 3 alpha-hydroxysteroid and 3 beta-hydroxysteroid dehydrogenases from human liver cytosol. Hepatology 16, 365-71.
33. Tomkins, G. M. (1956). A mammalian 3 alpha-hydroxysteroid dehydrogenase. J. Biol. Chem. 218, 437-47.
34. Weinstein, B. I., Gordon, G. G. and Southren, A. L. (1983). Potentiation of glucocorticoid activity by 5 beta-dihydrocortisol: its role in glaucoma. Science 222, 172-3.
35. Weinstein, B. I., Munnangi, P., Gordon, G. G. and Southren, A. L. (1985). Defects in cortisol-metabolizing enzymes in primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 26, 890-3.
36. Weinstein, B. I., Kandalaft, N., Ritch, R., Camras, C. B., Morris, D. J., Latif, S. A., Vecsei, P., Vittek, J., Gordon, G. G. and Southren, A. L. (1991). 5 alpha-dihydrocortisol in human aqueous humor and metabolism of cortisol by human lenses in vitro. Invest. Ophthalmol. Vis. Sci. 32, 2130-5.
37. Worner, W. and Oesch, F. (1984). Identity of Dihydrodiol dehydrogenase and 3 alpha-hydroxysteroid dehydrogenase in rat but not in rabbit liver cytosol. FEBS Lett. 170, 263-7.