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Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis
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FK 506: Historical perspectives
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T. Goto, T. Kino, H. Hatanka, M. Okuhara, M. Kohsaka, H. Aoki, and H. Imanaka. FK 506: Historical perspectives. Transplant. Proc. 23:2713-2717 (1991).
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A highly sensitive method to assay FK-506 levels in plasma
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A whole blood FK506 assay for the IMx® analyzer
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F. C. Granier, J. Loczkiw, M. Bergmann, S. Luntra, M. Morrison, D. Blonski, K. Shoemaker, and M. Kobayashi. A whole blood FK506 assay for the IMx® analyzer. Transplant. Proc. 23: 2748-2749 (1991).
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Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.e.-MS and microparticle enzyme immunoassay (MEIA)
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A.-K. Gonschior, U. Christians, F. Braun, M. Winkler, A. Linck, J. Baumann, and K.-Fr. Sewing. Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.e.-MS and microparticle enzyme immunoassay (MEIA). Br. J. Clin. Pharmacol. 38: 567-571 (1994).
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S. H. Vincent, B. V. Karanam, S. K. Painter, and S.-H. L. Chiu. In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism. Arch. Biochem. Biophys. 294: 454-460 (1992).
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T. Shiraga, H. Matsuda, K. Nagase, K. Iwasaki, K. Noda, H. Yamazaki, T. Shimada, and Y. Funae. Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes. Biochem. Pharmacol. 47: 727-735 (1994).
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K. Iwasaki, T. Shiraga, K. Nagase, Z. Tozuka, K. Noda, S. Sakuma, R. Fujitsu, K. Shimatani, A. Sato, and M. Fujioka. Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone. Drug Metab. Dispos. 21: 971-977 (1993).
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R. D'Ambrosio, N. Girzaitis, and W. J. Jusko. Validation and quality assurance program for monitoring tacrolimus (FK 506) concentrations in plasma and whole blood. Ther. Drug Monit. 15:414-426 (1993).
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Further metabolism of FK506 (tacrolimus). Indentification and biological activities of the metabolites oxidized at multiple sites of FK506
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K. Iwasaki, T. Shiraga, H. Matsuda, K. Nagase, Y. Tokuma, T. Hata, Y. Fijii, S. Sakuma, T. Fujitsu, A. Fujikawa, K. Shimatani, A. Sato, and M. Fujioka. Further metabolism of FK506 (tacrolimus). Indentification and biological activities of the metabolites oxidized at multiple sites of FK506. Drug Metab. Dispos. 23:28-34 (1995).
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9044229393
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Tacrolimus (FK506) metabolite pattern in blood from liver and kidney transplant patients
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submitted
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A.-K. Gonschior, U. Christians, M. Winkler, A. Linck, J. Bauman, K.-Fr. Sewing. Tacrolimus (FK506) metabolite pattern in blood from liver and kidney transplant patients. Clin. Pharmacol. Ther. submitted, 1995.
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Gonschior, A.-K.1
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Linck, A.4
Bauman, J.5
Sewing, K.-Fr.6
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