Molecular mechanisms used in the regulation of aggrecan and link protein synthesis by chondrocytes

American Journal of Therapeutics

Volumn 3, Issue 2, 1996, Pages 129-133

  Ratcliffe, Anthony ^a,b   Fischer, Stuart ^a   Valhmu, Wilmot B ^a   Vostrejs, Michael ^a   Saed Nejad, Fatemeh ^a   Ebara, Sohei ^a   Palmer, Glyn ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b New York Presbyterian Hospital Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; CHONDROITIN SULFATE; COLLAGEN; CYTOKINE; GLYCOPROTEIN; GLYCOSAMINOGLYCAN; HYALURONIC ACID; INTERLEUKIN 1; KERATAN SULFATE; LINK PROTEIN; MESSENGER RNA; OLIGOSACCHARIDE; PROTEINASE; PROTEOGLYCAN; SCLEROPROTEIN; VERSICAN;

ARTHROPATHY; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; EXON; EXTRACELLULAR MATRIX; GENE; HUMAN; INTRON; NONHUMAN; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

EID: 0029865363     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-199602000-00006     Document Type: Article

References (24)

1. Heinegard D, Oldberg A: Structure and biology of cartilage and bone noncollagenous macromolecules. FASEB J 1989;3:2042-2051.
2. Mow VC, Ratcliffe A, Poole AR: Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures. Biomaterials 1992;13:67-97.
3. Hardingham TE, Fosang A: Proteoglycans: many forms and many functions. FASEB J 1992;6:861-870.
4. Hardingham TE: The role of link protein in the structure of cartilage proteoglycan aggregates. Biochem J 1979;177: 237-247.
5. Morgelin M, Heinegard D, Engel J, Paulsson M: The cartilage proteoglycan aggregate: assembly through combined protein-carbohydrate and protein-protein interactions. Biophys Chem 1994;50:113-128.
6. Lohmander LS, Roos H, Dahlberg L, Hoerrner LA, Lark MW: Temporal patterns of stromelysin-1, tissue inhibitor, and proteoglycan fragments in human knee joint fluid after injury to the cruciate ligament or meniscus. J Orthop Res 1994;12:21-28.
7. Ratcliffe A, Beauvais PJ, Saed-Nejad F: Differential levels of aggrecan aggregate components in synovial fluids from canine knee joints with experimental osteoarthritis and disuse. J Orthop Res 1994;12:464-473.
8. Hering TM, Sandell LJ: Biosynthesis and processing of bovine cartilage link protein. J Biol Chem 1990;265:2375-2382.
9. Kimura JH, Shinomura T, Thonar EJMA: Biosynthesis of cartilage proteoglycan and link protein. Methods Enzymol 1987;144:272-393.
10. Ratcliffe A, Fryer PR, Hardingham TE: Proteoglycan biosynthesis in chondrocytes: protein A-gold localization of proteoglycan protein core and chondroitin sulfate within Golgi subcompartments. J Cell Biol 1985;101:2355-2365.
11. Ratcliffe A, Hughes C, Fryer PR, Saed-Nejad F, Hardingham T: Immunochemical studies of the synthesis and secretion of link protein and aggregating proteoglycan by chondrocytes. Coll Rel Res 1987;7:409-421.
12. Rhodes C, Savagner P, Line S, Sasaki M, Chrigos M, Doege K, Yamada Y: Characterization of the promoter for the rat and human link protein gene. Nucl Acids Res 1991;19:1933-1939.
13. Doege K: Personal communication.
14. Doege KJ, Sasaki M, Kimura T, Yamada Y: Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. J Biol Chem 1991;266:894-902.
15. Plaas AHK, Sandy JD, Kimura JH: Biosynthesis of cartilage proteoglycan and link protein by articular chondrocytes from immature and mature rabbits. J Biol Chem 1988;263:7560-7566.
16. Kahar V-M, Larjava H, Uitto J: Differential regulation of extracellular matrix proteoglycan (PG) gene expression. J Biol Chem 1991;266:10608-10615.
17. Pearson D, Sasse J: Differential regulation of biglycan and decorin by retinoic acid in bovine chondrocytes. J Biol Chem 1992;267:25364-25370.
18. Tyler JA: Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules. Biochem J 1985;227:869-878.
19. Horton WE, Balakir R, Precht P, Liang CT: 1,25-Dihydroxyvitamin D down regulates aggrecan proteoglycan expression in immortilized rat chondrocytes through a posttranscriptional mechanism. J Biol Chem 1991;266: 24808-24808.
20. Doege K, Sasaki M, Horigan E, Hassell JR, Yamada Y: Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones. J Biol Chem 1987;262:17757-17767.
21. Li H, Swartz NB, Vertel BM: cDNA cloning of chick cartilage chondroitin sulfate (aggrecan) core protein and identification of a stop codon in the aggrecan gene associated with the chondrodystrophy, nanomelia. J Biol Chem 1993;268:23504-23511.
22. Doege K, Sasaki M, Yamada Y: Rat and human cartilage proteoglycan (aggrecan) gene structure. Biochem Soc Trans 1990;18:200-202.
23. Valhmu WB, Palmer GD, Rivers PA, Ebara S, Cheng J-F, Fischer S, Ratcliffe A: Structure of the human aggrecan gene: exon-intron organization and association with the protein domains. Biochem J 1995; in press.
24. Ratcliffe A, Hardingham T: Cartilage proteoglycan binding region and link protein; radio-immunoassays and the detection of masked determinants in aggregates. Biochem J 1983;213:371-378.