Octreotide differentially modulates human Caco-2 intestinal epithelial cell proliferation and differentiation by decreasing intracellular cAMP

Regulatory Peptides

Volumn 61, Issue 3, 1996, Pages 219-227

  Sgambati, Susan A ^a   Zarif, Abdul ^a   Basson, Marc D ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenylate cyclase; Alkaline phosphatase; Cell matrix interaction; Cellular motility; Dipeptidyl dipeptidase; Somatostatin

Indexed keywords

ADENYLATE CYCLASE; ALKALINE PHOSPHATASE; BUCLADESINE; CYCLIC AMP; DIPEPTIDASE; INTEGRIN; MITOMYCIN C; OCTREOTIDE; SOMATOSTATIN DERIVATIVE;

ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; DIGESTION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTESTINE BRUSH BORDER; INTESTINE EPITHELIUM CELL; MITOGENESIS; PRIORITY JOURNAL;

EID: 0029864954     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-0115(95)00163-8     Document Type: Article

References (46)

1. Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M. and Rivier J., Hypothalamic polypeptide that inhibits secretion of immunoreactive pituitary growth hormone, Science, 179 (1973) 77-79.
2. Evers, B.M., Parekh, D., Townsend, C.M. and Thompson, J.C., Somatostatin and analogs in the treatment of cancer, Ann. Surg., 213 (1991) 190-198.
3. Lamberts, S.W., Koper, J.W. and Reubi, J.C., Potential role of somatostatin analogues in the treatment of cancer, Eur. J. Clin. Invest., 17 (1987) 281-287.
4. Bjork, J., Nilsson, J., Hultcrantz, R. and Johansson, C., Growth-regulatory effects of sensory neuropeptides, epidermal growth factor, insulin and somatostatin on the non-transformed intestinal epithelial cell line IEC-6 and the colon cancer cell line HT-29, Scand. J. Gastroenterol., 5 (1993) 879-884.
5. Thompson, J.S., Nguyen, B.L. and Harty, R.F., Somatostatin analogue inhibits intestinal regeneration, Arch. Surg., 128 (1993) 385-389.
6. Singh, P., Le, S., Townsend, C.M. Jr., Beauchamp, R.D., Laridjani, A. and Thompson, J.C., A long-acting somatostatin analog (SRIF) (SMS-995) and proglumide inhibit the trophic and gastrin receptor regulatory effects of pentagastrin on mouse colon cancer (MC-26) cells in vivo, Gastroenterology, 90 (1986) 1636.
7. Lehy, T., Dubrasquet, M. and Bonfils, S., Effect of somatostatin on normal and gastric-stimulated cell proliferation in the gastric and intestinal mucosa of the rat, Digestion, 19 (1979) 99-109.
8. Smith, J.P. and Solomon, T.E., Effects of gastrin, proglumide and somatostatin on growth of human colon cancer, Gastroenterology, 95 (1988) 1541-1548.
9. Stange, E.F., Schneider, A., Schusdziarra, V. and Ditschuneit, H., Inhibitory effects of somatostatin on growth and differentiation in cultured intestinal mucosa, Horm. Metab. Res., 16 (1984) 74-78.
10. Conteas, C.N. and Majumdar, A.P., The effects of gastrin, epidermal growth factor, and somatostatin on DNA synthesis in a small intestinal crypt cell line (IEC-6), Proc. Soc. Exp. Biol. Med., 184 (1987) 301-311.
11. Chantret, I., Barbat, A., Dussaulx, E., Brattain, M.G. and Zweibaum, A., Epithelial polarity, villin expression and enterocytic differentiation of cultured human colon carcinoma cells: A survey of twenty cell lines, Cancer Res., 48 (1988) 1936-1942.
12. BBe clones of the human intestinal cell line, Caco-2, J. Cell Sci., 102 (1992) 581-600.
13. Basson, M.D., Modlin, I.M. and Madri, J.A., Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor, J. Clin. Invest., 90 (1992) 15-23.
14. Turowski, G.A., Rashid, Z., Hong, F., Madri, J.A. and Basson, M.D., Glutamine modulates phenotype and stimulates proliferation in human colon cancer cell lines, Cancer Res., 54 (1994) 5974-5980.
15. Basson, M.D., Beidler, D.R., Turowski, G.A., Zarif, A., Modlin, I.M., Jena, B.P. and Madri, J.A., Effect of tyrosine kinase inhibition on basal and epidermal growth factor-stimulated human Caco-2 enterocyte sheet migration, J. Clin. Invest., 160 (1994) 491-501.
16. Basson, M.D., Modlin, I.M., Flynn, S.D., Jena, B.P. and Madri, J.A., Independent modulation of enterocyte migration and proliferation by growth factors, matrix proteins and pharmacologic agents in an in vitro model of mucosal healing, Surgery, 112 (1992) 299-308.
17. Ishizuka, J., Beauchamp, R.D., Evers, B.M., Townsend, C.M. Jr. and Thompson, J.C., Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells, Biochem. Biophys. Res. Commun., 185 (1992) 577-581.
18. Yannariello-Brown, J., Wewer, U., Liotta, L. and Madri, J.A., Distribution of a 69-kD-Laminin-binding protein in aortic and microvascular endothelial cells: modulation during cell attachment, spreading and migration, J. Cell Biol., 106 (1988) 1773-1786.
19. Madri, J.A., Pratt, B.M., Yannariello-Brown, J., Matrix-driven cell size change modulates aortic endothelial cell proliferation and sheet migration, Am. J. Pathol., 132 (1988) 18-27.
20. Hierowski, M.T., Liebow, C., du Sapin, K. and Schally, A.V., Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line, FEBS Lett., 179 (1985) 252-256.
21. Liebow, C., Reilly, C., Serrano, M. and Schally, A.V., Somatostatin analog inhibits growth of pancreatic cancer by stimulating tyrosine phosphatase, Proc. Natl. Acad. Sci. USA, 86 (1989) 2003-2007.
22. Weckbecker, G. Raulf, F. Stolz, B. and Bruns, C., Somatostatin analogs for diagnosis and treatment of cancer, Pharmacol. Ther., 60 (1993) 245-264.
23. Basson, M.D. and Hong, F., The metabolites of different dietary fibers exert distinct effects on human (Caco-2) colonocytes, Surg. Forum, 45 (1994) 192-194.
24. Basson, M.D., Hong, F. and Emenaker, N.J., Specific modulation of intestinal epithelial brush border enzyme expression by a phorbol ester, J. Surg. Res., 59 (1995) 121-127.
25. Koper, J.W., Markstein, R., Kohler, C., Kwekkeboom, D.J., Avezaat, C.J., Lamberts, S.W. and Reubi, J.C., Somatostatin inhibits the activity of adenylate cyclase in cultured human meningioma cells and stimulates their growth, J. Clin. Endocrinol. Metab., 74 (1992) 543-547.
26. Mascardo, R.N. and Sherline, P., Somatostatin inhibits rapid centrosomal separation and cell proliferation induced by epidermal growth factor, Endocrinology, 11 (1982) 1394-1396.
27. 1 (42484), Proc. Soc. Exp. Biol. Med., 184 (1987) 307-311.
28. Bishop, W.P., Wen, J.T., Regulation of Caco-2 cell proliferation by basolateral membrane epidermal growth factor receptors, Am. J. Physiol., 267 (1994) G892-900.
29. Andoh, A., Fujiyama, Y., Bamba, T. and Hosoda, S., Differential cytokine regulation of complement C3, C4 and factor B synthesis in human intestinal epithelial cell line, Caco-2, J. Immunol., 151 (1993) 4239-4247.
30. Evers, B.M., Ehrenfried, J.A., Townsend, C.M., Thompson, J.C., Developmental expression of neurotensin is mediated by changes in gene transcription, Surg Forum, 46 (1995) 198-200.
31. Harris, A.G., Somatostatin and somatostatin analogues: pharmacokinetics and pharmacodynamics. Gut, Suppl. 3 (1994) S1-S4.
32. Koch, T.R., Carney, J.A., Morris, V.A. and Go, V.L., Somatostatin in the idiopathic inflammatory bowel diseases, Dist. Colon Rectum, 31 (1988) 198-203.
33. Miller, G.V., Preston, S.R., Woodhouse, L.F., Faumery, S.M. and Primrose, J.N., Somatostatin binding in human gastrointestinal tissues: effects of cations and somatostatin analogs. Gut, 34 (1993) 1351-1356.
34. Basson, M.D. and Hong, F., Modulation of human Caco-2 intestinal epithelial cell phenotype by protein kinase C inhibitors, Cell Biol Int., in press.
35. Basson, M.D. and Hong, F., Regulation of human Caco-2 intestinal epithelial brush border enzyme activity by cyclic nucleotides, Cancer Lett, in press.
36. Kokudo, N., Kothary, P.C., Eckhauser, F.E., Nakamura, T. and Raper, S.E., Inhibition of DNA synthesis by somatostatin in rat hepatocytes stimulated by hepatocyte growth factor or epidermal growth factor, Am. J. Surg., 163 (1992) 169-173.
37. Pruthi, R.S., Farouk, M. Tsai, W.-H., Michalopoulos, G. and Meyers, W.C., The effect of octreotide on hepatic regeneration in rats, Surgery, 113 (1993) 84-89.
38. Alonso, H.J., Galera, M.-J., Reyes, G., Vinals, A., Resell, E. and Rius, X., Effet de l'analog de la somatostatine SMS 201-995 sur croissance in vitro et in vivo de l'adenocarcinome du colon de souris CT 26, Gastroenterol. Clin. Biol., 16 (1992) 12-15.
39. Bimbaumer, L., Abramowitz, J., Brown, A.M., Receptor-effector coupling by G proteins. Biochim. Biophys. Acta, 1031 (1990) 163-224.
40. i protein subunits during the differentiation in intestinal crypt-villus axis: regulation at the mRNA level, Am. J. Physiol., 262 (1992) C1478-C1484.
41. Tortora, G., Yokozaki, H. Pepe, S., Clair, T. and Cho-Chung, Y.S., Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dpendent protein kinase, Proc. Natl. Acad. Sci. USA, 88 (1991) 2011-2015.
42. Dumont, J.E., Jauniaux, J.-C. and Roger, P.P., The cyclic AMP-mediated stimulation of cell proliferation, Trends Biochem. Sci., 14 (1989) 67-71.
43. Rousset, M., The human colon carcinoma cell lines HT-29 and Caco-2: two in vitro models for the study of intestinal differentiation, Biochemie, 68 (1986) 1035-1040.
44. Jumarie, C. and Malo, C., Caco-2 cells cultured in serum-free medium as a model for the study of enterocytic differentiation in vitro, J. Cell. Physiol., 149 (1991) 24-33.
45. Basson, M.D., Modlin, I.M., Turowski, G.A. and Madri, J.A., Enterocyte-matrix interactions in the healing of mucosal injury, Eur. J. Gastroenterol., 93 (5 Suppl. 3) (1993) F21-F28.
46. Madri, J.A. and Basson, M.D., Extracellular matrix-cell interactions: dynamic modulators of cell, tissue and organism structure and function, Lab. Invest., 66 (1992) 519-521.