Polyglutamylation of the dihydrofolate reductase inhibitor γ-methylene-10-deazaaminopterin is not essential for antitumor activity

Clinical Cancer Research

Volumn 2, Issue 4, 1996, Pages 707-712

  Cao, S ^c   Abraham, A ^a   Nair, M G ^a,c   Pati, R ^a   Galivan, J H ^d   Hausheer, F H ^b   Rustum, Y M ^c  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b BioNumerik Pharmaceuticals Inc   (United States)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

^d WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPTERIN DERIVATIVE; DIHYDROFOLATE REDUCTASE INHIBITOR; ENZYME INHIBITOR; GAMMA METHYLENE 10 DEAZAAMINOPTERIN; METHOTREXATE; POLYGLUTAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL LINE; TUMOR XENOGRAFT;

AMINOPTERIN; ANIMALS; ANTINEOPLASTIC AGENTS; FEMALE; FOLIC ACID ANTAGONISTS; HUMANS; LEUCOVORIN; METHOTREXATE; MICE; MICE, INBRED DBA; POLYGLUTAMIC ACID;

EID: 0029864768     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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