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Volumn 62, Issue 3, 1996, Pages 798-803

Biotransformation of chlorpromazine and methdilazine by Cunninghamella elegans

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYMETHDILAZINE; 3 HYDROXYMETHDILAZINE; 7 HYDROXYCHLORPROMAZINE SULFOXIDE; 7 HYDROXYNORCHLORPROMAZINE; CHLORPROMAZINE; CHLORPROMAZINE N OXIDE; CHLORPROMAZINE SULFOXIDE; CYTOCHROME P450 INHIBITOR; DRUG METABOLITE; ENZYME INHIBITOR; METHDILAZINE; METHDILAZINE N OXIDE; METHDILAZINE SULFOXIDE; METYRAPONE; NORCHLORPROMAZINE; OXYGEN; PHENOTHIAZINE; PROADIFEN; UNCLASSIFIED DRUG;

EID: 0029863975     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/aem.62.3.798-803.1996     Document Type: Article
Times cited : (39)

References (29)
  • 1
    • 0017714060 scopus 로고
    • Levels of chlorpromazine and its active metabolites in rat brain and the relationship to central monoamine metabolism and prolactin secretion
    • Alfredsson, G., F. A. Wiesel, and P. Skett. 1977 Levels of chlorpromazine and its active metabolites in rat brain and the relationship to central monoamine metabolism and prolactin secretion. Psychopharmacology 53:13-18
    • (1977) Psychopharmacology , vol.53 , pp. 13-18
    • Alfredsson, G.1    Wiesel, F.A.2    Skett, P.3
  • 2
    • 37049084555 scopus 로고
    • Catalytic oxidation of chlorpromazine and related phenothiazines. Cation radicals as the reactive intermediates in sulfoxide formation
    • Bosch, E., and J. K. Kochi. 1995. Catalytic oxidation of chlorpromazine and related phenothiazines. Cation radicals as the reactive intermediates in sulfoxide formation. J Chem. Soc. Perkin Trans. 1:1057-1064.
    • (1995) J Chem. Soc. Perkin Trans. , vol.1 , pp. 1057-1064
    • Bosch, E.1    Kochi, J.K.2
  • 3
    • 0021700508 scopus 로고
    • Microbial metabolism of polycyclic aromatic hydrocarbons
    • Cerniglia, C. E. 1984. Microbial metabolism of polycyclic aromatic hydrocarbons Adv. Appl. Microbiol. 30:31-71.
    • (1984) Adv. Appl. Microbiol. , vol.30 , pp. 31-71
    • Cerniglia, C.E.1
  • 4
    • 0017876277 scopus 로고
    • Metabolism of naphthalene by cell extracts of Cunninghamella elegans
    • Cerniglia, C. E., and D. T. Gibson. 1978 Metabolism of naphthalene by cell extracts of Cunninghamella elegans. Arch. Biochem. Biophys. 186:121-127
    • (1978) Arch. Biochem. Biophys. , vol.186 , pp. 121-127
    • Cerniglia, C.E.1    Gibson, D.T.2
  • 5
    • 0027177990 scopus 로고
    • Antimycobacterial activity of methdilazine, an antimicrobial phenothiazine
    • Chakrabarty, A. N., C. P. Bhattacharya, and S. G. Dastidar. 1993. Antimycobacterial activity of methdilazine, an antimicrobial phenothiazine. APMIS 101:449-454.
    • (1993) APMIS , vol.101 , pp. 449-454
    • Chakrabarty, A.N.1    Bhattacharya, C.P.2    Dastidar, S.G.3
  • 6
    • 0023773258 scopus 로고
    • Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents
    • Chattopadhyay, D., S. G. Dastidar, and A. N. Chakrabarty. 1988. Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents. Arzneimittel-Forschung 38:869-872.
    • (1988) Arzneimittel-Forschung , vol.38 , pp. 869-872
    • Chattopadhyay, D.1    Dastidar, S.G.2    Chakrabarty, A.N.3
  • 7
    • 0025916503 scopus 로고
    • Use of microorganisms for the study of drug metabolism an update
    • Clark, A. M., and C. D. Hufford. 1991. Use of microorganisms for the study of drug metabolism an update. Med. Res. Rev 11:473-501.
    • (1991) Med. Res. Rev , vol.11 , pp. 473-501
    • Clark, A.M.1    Hufford, C.D.2
  • 8
    • 0014115863 scopus 로고
    • The metabolism of chlorpromazine by liver microsomal enzyme systems
    • Coccia, P. F., and W. W. Westerfeld. 1967. The metabolism of chlorpromazine by liver microsomal enzyme systems. J Pharmacol Exp Ther. 157: 446-458.
    • (1967) J Pharmacol Exp Ther. , vol.157 , pp. 446-458
    • Coccia, P.F.1    Westerfeld, W.W.2
  • 9
    • 0000470002 scopus 로고
    • Microbial models of mammalian drug metabolism
    • Davis, P. J. 1988. Microbial models of mammalian drug metabolism Dev. Ind. Microbiol 29:197-219.
    • (1988) Dev. Ind. Microbiol , vol.29 , pp. 197-219
    • Davis, P.J.1
  • 10
    • 0017153984 scopus 로고
    • Aryl hydrocarbon hydroxylase activity in the fungus Cunninghamella bainieri. evidence for the presence of cytochrome P-450
    • Ferris, J. P., L. H. MacDonald, M. A. Patrie, and M. A. Martin. 1976. Aryl hydrocarbon hydroxylase activity in the fungus Cunninghamella bainieri. evidence for the presence of cytochrome P-450 Arch. Biochem. Biophys. 175: 443-452.
    • (1976) Arch. Biochem. Biophys. , vol.175 , pp. 443-452
    • Ferris, J.P.1    MacDonald, L.H.2    Patrie, M.A.3    Martin, M.A.4
  • 11
    • 0021512656 scopus 로고
    • Studies on the mechanism of microbial N-demethylation of codeine by cell-free extracts of Cunninghamella bainien
    • Gibson, M., C. J. Soper, R. T. Parfitt, and G. J. Sewell. 1984. Studies on the mechanism of microbial N-demethylation of codeine by cell-free extracts of Cunninghamella bainien. Enzyme Microb Technol. 6:471-475.
    • (1984) Enzyme Microb Technol. , vol.6 , pp. 471-475
    • Gibson, M.1    Soper, C.J.2    Parfitt, R.T.3    Sewell, G.J.4
  • 13
    • 0013772594 scopus 로고
    • Metabolism of chlorpromazine. Confirmation of position 7 as the major site of hydroxylation
    • Goldenberg, H., and V. Fishman. 1964. Metabolism of chlorpromazine. Confirmation of position 7 as the major site of hydroxylation. Biochem. Biophys. Res. Commun. 14:404-407.
    • (1964) Biochem. Biophys. Res. Commun. , vol.14 , pp. 404-407
    • Goldenberg, H.1    Fishman, V.2
  • 14
    • 17644432444 scopus 로고
    • Inhibition of the alternative pathways of chlorpromazine metabolism in vitro
    • Gorrod, J. W., C. R. Lazarus, and A. H. Beckett. 1972. Inhibition of the alternative pathways of chlorpromazine metabolism in vitro Biochem. J. 130: 13p.
    • (1972) Biochem. J. , vol.130
    • Gorrod, J.W.1    Lazarus, C.R.2    Beckett, A.H.3
  • 15
    • 0025307009 scopus 로고
    • Mechanisms of cytochrome P450 catalysis
    • Guengerich, F. P., and T. L. MacDonald. 1990. Mechanisms of cytochrome P450 catalysis. FASEB J. 4:2453-2459.
    • (1990) FASEB J. , vol.4 , pp. 2453-2459
    • Guengerich, F.P.1    MacDonald, T.L.2
  • 16
    • 0020532457 scopus 로고
    • Chlorpromazine metabolism in extracts of liver and small intestine from guinea pig and from man
    • Hartmann, F., L. D. Gruenke, J. C. Craig, and D. M. Bisseli. 1983. Chlorpromazine metabolism in extracts of liver and small intestine from guinea pig and from man. Drug Metab. Dispos. 11:244-248.
    • (1983) Drug Metab. Dispos. , vol.11 , pp. 244-248
    • Hartmann, F.1    Gruenke, L.D.2    Craig, J.C.3    Bisseli, D.M.4
  • 17
    • 0002844452 scopus 로고
    • The role of cytochrome P-450 in the metabolism of chemical carcinogens
    • F. P Guengerich (ed.). CRC Press, Inc , Boca Raton, Fla.
    • Kadlubar, F. F., and G. J. Hammons. 1987. The role of cytochrome P-450 in the metabolism of chemical carcinogens. p 81-130. In F. P Guengerich (ed.). Mammalian cytochrome P450, vol. II. CRC Press, Inc , Boca Raton, Fla.
    • (1987) Mammalian Cytochrome P450 , vol.2 , pp. 81-130
    • Kadlubar, F.F.1    Hammons, G.J.2
  • 19
    • 0007555774 scopus 로고
    • Psychotropic drugs
    • P. L. Morselli (ed.), Spectrum Publications, New York
    • Morselli, P. L. 1977. Psychotropic drugs, p 431-474. In P. L. Morselli (ed.), Drug deposition during development. Spectrum Publications, New York.
    • (1977) Drug Deposition during Development , pp. 431-474
    • Morselli, P.L.1
  • 20
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes
    • Omura, T., and R. Sato. 1964 The carbon monoxide-binding pigment of liver microsomes. J. Biol. Chem. 239:2370-2378.
    • (1964) J. Biol. Chem. , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 21
    • 0013859843 scopus 로고
    • Biotransformation in vitro undergone by phenothiazine derivatives in a liver preparation
    • Robinson, A. E. 1966. Biotransformation in vitro undergone by phenothiazine derivatives in a liver preparation. J. Pharm. Pharmacol. 18:19-32.
    • (1966) J. Pharm. Pharmacol. , vol.18 , pp. 19-32
    • Robinson, A.E.1
  • 22
    • 0028566571 scopus 로고
    • P450 catalysed S-oxidation of dibenzothiophene by Cunninghamella elegans
    • Schlenk, D., R. J. Bever, A. M. Vertino, and C. E. Cerniglia. 1994. P450 catalysed S-oxidation of dibenzothiophene by Cunninghamella elegans. Xenobiotica 24:1077-1083.
    • (1994) Xenobiotica , vol.24 , pp. 1077-1083
    • Schlenk, D.1    Bever, R.J.2    Vertino, A.M.3    Cerniglia, C.E.4
  • 23
    • 0003104917 scopus 로고
    • Microbial transformations as means of preparing mammalian drug metabolites
    • J. P. Rosazza (ed.), CRC Press, Inc., Boca Raton, Fla.
    • Smith, R. V., and J. P. Rosazza. 1982 Microbial transformations as means of preparing mammalian drug metabolites, p. 1-42. In J. P. Rosazza (ed.), Microbial transformation of bioactive compounds, vol. II. CRC Press, Inc., Boca Raton, Fla.
    • (1982) Microbial Transformation of Bioactive Compounds , vol.2 , pp. 1-42
    • Smith, R.V.1    Rosazza, J.P.2
  • 25
    • 0018758332 scopus 로고
    • Sulfoxidation of chlorpromazine and thioridazine by bovine liver-preferential metabolic pathways
    • Traficante, L. J., J. Siekierski, G. Sakalis, and S. Gershon. 1979. Sulfoxidation of chlorpromazine and thioridazine by bovine liver-preferential metabolic pathways. Biochem. Pharmacol. 28:621-626.
    • (1979) Biochem. Pharmacol. , vol.28 , pp. 621-626
    • Traficante, L.J.1    Siekierski, J.2    Sakalis, G.3    Gershon, S.4
  • 26
    • 0015117229 scopus 로고
    • The assay of chlorpromazine and metabolites in blood, urine, and other tissues
    • Usdin, E. 1971. The assay of chlorpromazine and metabolites in blood, urine, and other tissues. Crit. Rev. Clin. Lab Sci. 2:347-391.
    • (1971) Crit. Rev. Clin. Lab Sci. , vol.2 , pp. 347-391
    • Usdin, E.1
  • 27
    • 0019432257 scopus 로고
    • Concentrations of chlorpromazine and two of its active metabolites in plasma and cerebrospinal fluid of psychotic patients treated with fixed drug doses
    • Wode-Helgodt, B., and G. Alfredsson. 1981. Concentrations of chlorpromazine and two of its active metabolites in plasma and cerebrospinal fluid of psychotic patients treated with fixed drug doses. Psychopharmacology 73: 55-62.
    • (1981) Psychopharmacology , vol.73 , pp. 55-62
    • Wode-Helgodt, B.1    Alfredsson, G.2
  • 28
    • 0027431392 scopus 로고
    • Microbial models of mammalian metabolism: Involvement of cytochrome P450 in the N-demethylation of N-methylcarbazole by Cunninghamella echinulata
    • Yang, W., T. Jiang, and P. J. Davis. 1993. Microbial models of mammalian metabolism: involvement of cytochrome P450 in the N-demethylation of N-methylcarbazole by Cunninghamella echinulata. Xenobiotica 23:973-982.
    • (1993) Xenobiotica , vol.23 , pp. 973-982
    • Yang, W.1    Jiang, T.2    Davis, P.J.3
  • 29
    • 0023894686 scopus 로고
    • Flavin-containing monooxygenases: Catalytic mechanism and substrate specificities
    • Ziegler, D. M. 1988. Flavin-containing monooxygenases: catalytic mechanism and substrate specificities. Drug Metab. Rev. 19:1-32.
    • (1988) Drug Metab. Rev. , vol.19 , pp. 1-32
    • Ziegler, D.M.1


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