Chiral separation of local anaesthetics with capillary electrophoresis. Evaluation of the inclusion complex of the enantiomers with heptakis(2,6-di-O-methyl)-β-cyclodextrin

Chromatographia

Volumn 42, Issue 5-6, 1996, Pages 263-268

  Sanger van De Griend C E ^a   Groningsson K ^a   Westerlund, D ^b  

^a ASTRAZENECA R AND D   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Capillary electrophoresis; Dimethyl cyclodextrin; Enantiomer separation; Local anaesthetics; Triethanolamine

Indexed keywords

BUPIVACAINE; HEPTAKIS(2,6 O DIMETHYL) BETA CYCLODEXTRIN; LOCAL ANESTHETIC AGENT; MEPIVACAINE; PRILOCAINE; ROPIVACAINE;

ARTICLE; COMPLEX FORMATION; DRUG PURIFICATION; ENANTIOMER; PRIORITY JOURNAL; ZONE ELECTROPHORESIS;

EID: 0029863123     PISSN: 00095893     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02290307     Document Type: Article

References (25)

1. E. J. Ariëns, W. Soudijn, P. B. M. W. M. Timmermans, Eds., "Stereochemistry and Biological Activity of Drugs", Blackwell, London, 1983.
2. D. B. Campbell, Eur. J. Drug Metabol. Pharmacokinet. 15, 109 (1990).
3. A. R. Fassihi, Int. J. Pharm. 92, 1 (1993).
4. S. Fanali, J. Chromatogr. 545, 437 (1991).
5. R. Kuhn, S. Hoffstetter-Kuhn, Chromatographia 34, 505 (1992).
6. S. Terabe, K. Otsuka, H. Nishi, J. Chromatogr. A 666, 295 (1994).
7. C. Quang, M. G. Khaledi, Anal. Chem. 65, 3354 (1993).
8. H. Soini, M.-L. Riekkola, M. V. Novotny, J. Chromatogr. 608, 265 (1992).
9. S. A. C. Wren, R. C. Rowe, J. Chromatogr. 635, 113 (1993).
10. S. H. Penn, D. M. Goodall, J. S. Loran, J. Chromatogr. 636, 149 (1993).
11. S. Pálmarsdóttir, L.-E. Edholm, J. Chromatogr. A, 666, 337 (1994).
12. A. Amini, I. Beijersten, C. Pettersson, D. Westerlund, accepted for publication in J. Chromatogr. A.
13. S. H. Penn, G. Liu, E. T. Bergström, D. M. Goodall, J. S. Loran, J. Chromatogr. A, 680, 147 (1994).
14. A. Guttman, N. Cooke, J. Chromatogr. A, 680, 157 (1994).
15. M. M. Rogan, K. D. Altria, D. M. Goodall, Chirality 6, 25 (1994).
16. M. M. Rogan, K. D. Altria, D. M. Goodall, Chromatographia 38, 723 (1994).
17. C. E. Sänger-van de Griend, K. Gröningsson, accepted for publication in J. Pharm. Biomed. Anal.
18. S. A. C. Wren, R. C. Rowe, J. Chromatogr. 603, 235 (1992).
19. S. A. C. Wren, J. Chromatogr. 636, 57-62 (1993).
20. J. W. Jorgenson, K. D. Lukacs, Anal. Chem 53, 1298 (1981).
21. J. Bechet, Ph. Paques, M. Fillet, Ph. Hubert, J. Grommen, Electrophoresis 15, 818 (1994).
22. D. W. Armstrong, T. J. Ward, R. D. Armstrong, T. E. Beesley, Science 232, 1132 (1986).
23. J. Hermansson, J. Chromatogr. 269, 71 (1983).
24. J. Marie, P. Erlandsson, L. Hansson, R. Isaksson, C. Pettersson, G. Pettersson, J. Chromatogr. 586, 233 (1991).
25. J. Marie, S. Jönsson, R. Isaksson, C. Pettersson, G. Pettersson, J. Chromatogr. 648, 333-347 (1993).