A comparison of carboxylate salts as liposomal cryoprotectants

International Journal of Pharmaceutics

Volumn 131, Issue 2, 1996, Pages 257-262

  Lloyd, Andrew W ^a   Olliff, Cedric J ^a   Rutt, Ken J ^a  

^a UNIVERSITY OF BRIGHTON   (United Kingdom)

Author keywords

Betaines; Carboxylate salts; Cryopreservatives; Freezing and thawing; Liposome cryoprotectants; MLVs

Indexed keywords

BETAINE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CRYOPROTECTIVE AGENT; LIPOSOME; TETRYLAMMONIUM;

ARTICLE; CRYOPROTECTION; DRUG STORAGE; FREEZING; PRIORITY JOURNAL; SUSPENSION; THAWING;

EID: 0029863085     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04361-6     Document Type: Article

References (13)

1. Allen, T.M., Long-circulating (sterically stabilized) liposomes for targeted drug-delivery. Trends Pharmacol. Sci., 15 (1994) 215-220.
2. Ausborn, M., Nuhn, P. and Schreier, H., Stabilization of liposomes by freeze-thaw and lyophilization techniques -problems and opportunities. Eur. J. Pharm. Biopharm., 38 (1992) 133-139.
3. Brearley, C.A., Hodges, N.A. and Olliff, C.J., Membrane specificity of non-monotonic trends in cation-mediated injury to rapidly frozen phospholipid vesicles. Chem. Phys. Lipids, 59 (1991) 183-187.
4. Brearley, C.A., Hodges, N.A. and Olliff, C.J., Nonmonotonic trends in electrolyte-induced injury to rapidly cooled erythrocytes. Cryobiotogy, 29 (1992) 175-182.
5. Higgins, J., Hodges, N.A., Olliff, C.J. and Phillips, A.J., Factors influencing cryoprotective activity and drug leakage from liposomes after freezing. J. Pharm. Pharmacol., 38 (1986) 259-263.
6. Higgins, J., Hodges, N.A., Olliff, C.J. and Phillips, A.J., A comparative investigation of glycinebetaine and dimethylsulfoxide as liposome cryoprotectants. J. Pharm. Pharmacol., 39 (1987) 577-582.
7. Lloyd, A.W., Baker, J.A., Olliff, C.J. and Rutt, K.J., The evaluation of N-modified betaines as erythrocyte cryoprotectants. Cryo-Lett., 13 (1992a) 337-348.
8. Lloyd, A.W., Baker, J.A., Smith, G., Olliff, C.J. and Rutt, K.J., A comparison of glycine, sarcosine. N,N-dimethylglycine, glycinebetaine and N-modified betaines as liposome cryoprotectants. J. Pharm. Pharmacol., 44 (1992b) 507-511.
9. Lloyd, A.W., Olliff, C.J. and Rutt, K.J., A study of modified betaines as cryoprotective additives. J. Pharm. Pharmacol., 46 (1994) 704-707.
10. Macfarlane, D.R. and Forsyth, M., Recent insights on the role of cryoprotective agents in vitrification. Cryobiology, 27 (1990) 345-358.
11. Storey, R. and Wyn Jones, R.G., Quaternary ammonium compounds in plants in relation to salt stress. Phytochemistry, 16 (1977) 447-453.
12. Storm, G., Wilms, H.P. and Crommelin. D.J.A., Liposomes and biotherapeutics. Biotherapy, 3 (1991) 25-42.
13. Taylor, K.M.G. and Farr, S.J., Liposomes for drug delivery to the respiratory tract. Drug Dev. Ind. Pharm., 19 (1993) 123-142.