Calcineurin protein phosphatase activity in peripheral blood lymphocytes

Bone Marrow Transplantation

Volumn 17, Issue 3, 1996, Pages 309-313

  Rusnak, F ^a,b,d   Beressi, A H ^c   Haddy, A ^a   Tefferi, A ^a  

^a Division of Hematology and Internal Medicine   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^d MAYO CLINIC   (United States)

Author keywords

Cyclophilin; Cyclosporin A; FK506; FK506 binding protein, immunosuppression

Indexed keywords

CALCINEURIN; CYCLOPHILIN; CYCLOSPORIN A; ENZYME INHIBITOR; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; TRIFLUOPERAZINE;

ARTICLE; CELL LYSATE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOMODULATION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE;

AMINO ACID SEQUENCE; CALCINEURIN; CALMODULIN-BINDING PROTEINS; CYCLOSPORINE; DRUG RESISTANCE; ENZYME INHIBITORS; ETHERS, CYCLIC; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MOLECULAR SEQUENCE DATA; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; T-LYMPHOCYTES; TRIFLUOPERAZINE;

EID: 0029863033     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Crabtree GR. Contingent genetic regulatory events in T lymphocyte activation. Science 1989; 243: 355-361.
2. Weiss A, Littman DR. Signal transduction by lymphocyte antigen receptors. Cell 1994: 76: 263-274.
3. Elliot JF. Lin Y, Mizel SB et al. Induction of interleukin 2 messenger RNA inhibited by cyclosporin A. Science 1994; 226: 1439-1441.
4. Bierer BE, Mattila PS. Standaert RF et al. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 and rapamycin. Proc Natl Acad Sci USA 1990; 87: 9231-9235.
5. Handschumacher RE, Harding MW, Rice J et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science 1984; 226: 544-547.
6. Harding MW, Handschumacher RE, Speicher DW. Isolation and amino acid sequence of cyclophilin. J Biol Chem 1986; 261: 8547-8555.
7. Siekierka JJ, Hung SHY, Poe M et al. Cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature 1989; 341: 755-757.
8. Harding MW, Galat A, Uehling DE, Schreiber SL. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl- prolyl isomerase. Nature 1989; 341: 758-760.
9. Liu J, Farmer JD, Lane WS et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991; 66: 807-815.
10. Liu J. Albers MW, Wandless TJ et al. Inhibition of T cell signaling by immunophilin ligand complexes correlates with loss of calcineurin activity. Biochemistry 1992; 31: 3896-3901.
11. Fruman DA, Klee CB, Bierer BE, Burakoff SJ. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proc Natl Acad Sci USA 1992; 89: 3686-3690.
12. Swanson SK, Born T, Zydowsky LD et al. Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilins A and B. Proc Natl Acad Sci USA 1992; 89: 3741-3745.
13. Clipstone NA, Crabtree GR. Identification of calcineurin as a key enzyme in T lymphocyte activation. Nature 1992; 357: 695-697.
14. O'Keefe SJ, Tamura J. Kincaid RL et al. FK-506 and CsA sensitive activation of the interleukin-2 promoter by calcineurm. Nature 1992: 357: 692-694.
15. Flanagan WM. Corthésy B. Bram RJ. Crabtree GR. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 1991; 352: 803-807.
16. Northrop JP, Ho SN, Chen L et al. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 1994; 369: 497-502.
17. McCaffrey PG. Perrino BA. Soderling TR. Rao A. NF-ATp, a T lymphocyte DNA binding protein that is a target for calcineurin and immunosuppressive drugs. J Biol Chem 1993; 268: 3747-3752.
18. Jam J, McCaffrey PG, Miner Z et al. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 1993; 365: 352-355.
19. Cohen P, Cohen PTW. Protein phosphatases come of age. J Biol Chem 1989; 264: 21435-21438.
20. Shenolikar S, Nairn AC. Protein phosphatases: recent progress. In: Greengard P, Robison GA (eds). Advances in Second Messenger and Phosphoprotein Research. Vol. 23. Raven Press: New York. 1991, p 3-121.
21. Antoni FA, Shipston MJ, Smith SM. Inhibitory role for calcineurin in stimulus secretion coupling revealed by FK506 and cyclosporin A in pituitary corticotrope tumor cells. Biochem Biophys Res Comm 1993; 194: 226-233.
22. Groblewski GE, Wagner ACC, Williams JA. Cyclosporin A inhibits Ca2+/calmodulin dependent protein phosphatase and secretion in pancreatic acinar cells. J Biol Chem 1994; 269: 15111-15117.
23. Blumenthal DK, Takio K, Hansen RS, Krebs EG. Dephosphorylation of cAMP dependent protein kinase regulatory subunit (Type II) by calmodulin-dependent protein phosphatase. J Biol Chem 1986; 261: 8140-8145.
24. Dedman JR, Kaetzel MA. Calmodulin purification and fluorescent labeling. Methods Enzymol 1983; 102: 1-8.
25. Klee CB, Krinks MH, Manalan AS et al. Isolation, and characterization of bovine brain calcineurin: a calmodulin-stimulated protein phosphatase. Methods Enzymol 1983; 102: 227-244.
26. Liu J, Albers MW, Chen C-M et al. Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutageneis. Proc Natl Acad Sci USA 1990; 87: 2304-2308.
27. Hubbard MJ, Klee CB. Exogenous kinases and phosphatases as probes of intracellular modulation. In: Wheal H, Chad J (eds). Molecular Neurobiology: A Practical Approach. Oxford University Press: Oxford. 1991, p 135-157.
28. Rosenberg SA, Lipsky PE. Monocyte dependence of pokeweed mitogen-induced differentiation of immunoglobulin-secreting cells from human peripheral blood mononuclear cells. J Immunol 1979; 122: 926-931.
29. Thiele DL, Kurosaka M, Lipsky PE. Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood; delineation by its sensitivity to the lysosomal agent, L-leucine methyl ester. J Immunol 1983; 131: 2282-2290.
30. Galili U, Schlesinger M. The formation of stable E rosettes after neuraminidase treatment of either human peripheral blood lymphocytes or of sheep red blood cells. J Immunol 1974; 112: 1628-1634.
31. Bialojan C, Takai A. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem J 1988; 256: 283-290.
32. Cohen DJ, Loertscher R, Rubin MF et al. Cyclosporine: a new immunosuppressive agent for organ transplantation. Ann Intern Med 1984: 101: 667-682.
33. Kahan BD. Cyclosponne. New Engl J Med 1989; 321: 1725-1738.
34. Starzl TE. Klintmalm GBG. Porter KA et al. Liver transplantation with use of cyclosporin A and prednisone. New Engl J Med 1981; 305: 266-269.
35. Over PE, Stinson EB, Jamieson SW et al. Cyclosporine in cardiac transplantation: a 2 and 1/2 year follow-up. Transplant Proc 1983; 15: 330-336.
36. Deeg HJ, Storb R, Thomas ED et al. Cyclsporine as prophylaxis for graft-versus-host disease: a randomized study of patients undergoing marrow transplantation for acute nonlymphoblastic leukemia. Blood 1985; 65: 1325-1334.
37. Macleod AM, Thomson AW. FK506: an immunosuppressant for the 1990s? Lancet 1991; 337: 25-27.
38. Aperia A. Ibarra R. Svensson L-B et al. Calcineunn mediates alpha-adrenergic stimulation of Na+, K+-ATPase activity in renal tubule cells. Proc Natl Acad Sci USA 1992; 89: 7394-7397.
39. ε receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506 binding protein FKBP12. Proc Natl Acad Sci USA 1992; 89: 8542-8546.
40. Hendey B, Klee CB, Maxfield FR. Inhibition of neutrophil chemokinesis on vitronectin by inhibitors of calcineurin. Science 1992; 258: 296-299.
41. Foor F, Parent SA, Morin N et al. Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast. Nature 1992; 360: 682-684.
42. Goldfeld AE, Flemington EK, Boussiotis VA et al. Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FKL506 in human B cells. Proc Natl Acad Sci USA 1992; 89: 12198-12201.
43. Dutz JP, Fruman DA, Burakoff SJ, Bierer BE. A role for calcineurin in degranulation of murine cytotoxid T lymphocytes. J Immunol 1993; 150: 2591-2598.
44. Kincaid RL, Takayama H, Billingsley ML, Sitkovsky MV. Differential expression of calmodulin-binding proteins in B, T lymphocytes and thymocytes. Nature 1987; 330: 176-178.
45. Alexander DR, Hexham JM, Crumpton MJ. The association of type 1, 2A and 2B phosphatases with the human T lymphocyte plasma membrane. Biochem J 1988; 256: 885-892.
46. Pai SY, Fruman DA, Leong T et al. Inhibition of calcineurin phosphatase activity in adult bone marrow transplant patients treated with cyclosporin A. Blood 1994; 84: 3974-3979.